228 Result(s)

Article

Correction: Comparative analysis of chloroplast genomes of Pulsatilla species reveals evolutionary and taxonomic status of newly discovered endangered species Pulsatilla saxatilis

Hefei Xue, Che Bian, Wenjuan Hou, Wenxiao Men, Han Zheng… in BMC Plant Biology (2024)

Article

ALKBH5-mediated m⁶A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration

N6-methyladenosine (m⁶A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral disc degeneration (IDD), a common cause of low back pain, remains unclear.

Yu Lei, Enyu Zhan, Chao Chen, Yaoquan Hu, Zhengpin Lv, Qicong He… in Cell & Bioscience (2024)

Article

Super-resolution imaging of T lymphocyte activation reveals chromatin decondensation and disrupted nuclear envelope

T lymphocyte activation plays a pivotal role in adaptive immune response and alters the spatial organization of nuclear architecture that subsequently impacts transcription activities. Here, using stochastic o...

Jianquan Xu, Xuejiao Sun, Zhangguo Chen, Hongqiang Ma, Yang Liu in Communications Biology (2024)

Article

Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB

While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood.

Qi Liu, Yajuan Zhang, Huimin Li, Hong Gao, Yijie Zhou… in Cell Communication and Signaling (2024)

Article

The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif

PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyl...

**aolei Huang, Cheng Zhang, **nci Shang, Yichang Chen, Qin **ao… in Cell Death & Disease (2024)

Article

An electrophoretic mobility shift assay using the protein isolated from host plants

The electrophoretic mobility shift assay (EMSA) is a common technology to detect DNA-protein interactions. However, in most cases, the protein used in EMSA is obtained via prokaryotic expression, and rarely fr...

Zihang He, Zhibo Wang, Zhangguo Lu, Caiqiu Gao, Yucheng Wang in Plant Methods (2024)

Article

MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism

MiRNAs in mesenchymal stem cells (MSCs)-derived exosome (MSCs-exo) play an important role in the treatment of sepsis. We explored the mechanism through which MSCs-exo influences cognitive impairment in sepsis-...

Ying Ma, **ngguo She, Yang Liu, **an Qin in Communications Biology (2024)

Article

Two putative calcium-dependent protein kinases are involved in the regulation of sugarcane defense genes

Sugarcane is a primary sugar crop and an important source of bioenergy. Pathogens are the major factors affecting sugarcane yield and sugar content. However, the mechanisms of sugarcane defense regulation rema...

**angguo Li, Jiajie Zhong, Baiyang Li, Yingfeng Luo, Kailun Wang… in Phytopathology Research (2024)

Article

TIP aquaporins in Cyperus esculentus: genome-wide identification, expression profiles, subcellular localizations, and interaction patterns

Tonoplast intrinsic proteins (TIPs), which typically mediate water transport across vacuolar membranes, play an essential role in plant growth, development, and stress responses. However, their characterizatio...

Zhi Zou, Yujiao Zheng, Lili Chang, Liang** Zou, Li Zhang, Yi Min… in BMC Plant Biology (2024)

Article

Comparative analysis of chloroplast genomes of Pulsatilla species reveals evolutionary and taxonomic status of newly discovered endangered species Pulsatilla saxatilis

Pulsatilla saxatilis, a new species of the genus Pulsatilla has been discovered. The morphological information of this species has been well described, but its chloroplast genome characteristics and comparison wi...

Hefei Xue, Che Bian, Wenjuan Hou, Wenxiao Men, Han Zheng… in BMC Plant Biology (2024)

Article

Epiberberine: a potential rumen microbial urease inhibitor to reduce ammonia release screened by targeting UreG

Rumen microbial urease inhibitors have been proposed for regulating nitrogen emission and improving nitrogen utilization efficiency in ruminant livestock industry. However, studies on plant-derived natural inh...

**aoyin Zhang, Zhanbo **ong, Yue He, Nan Zheng… in Applied Microbiology and Biotechnology (2024)

Article

Elucidation of the genetic determination of body weight and size in Chinese local chicken breeds by large-scale genomic analyses

Body weight and size are important economic traits in chickens. While many growth-related quantitative trait loci (QTLs) and candidate genes have been identified, further research is needed to confirm and char...

Jie Wang, Jie Liu, Qiuxia Lei, Zhihe Liu, Haixia Han, Shuer Zhang, Chao Qi… in BMC Genomics (2024)

Article

‘Fertile island’ effects on the soil microbial community beneath the canopy of Tetraena mongolica, an endangered and dominant shrub in the West Ordos Desert, North China

The fertile islands formed by shrubs are major drivers of the structure and function of desert ecosystems, affecting seedling establishment, plant–plant interactions, the diversity and productivity of plant co...

Zhangkai Liu, Yuying Shao, Qingguo Cui, Xuehua Ye, Zhenying Huang in BMC Plant Biology (2024)

Article

LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy

In hepatocellular carcinoma (HCC), immunotherapy is vital for advanced-stage patients. However, diverse individual responses and tumor heterogeneity have resulted in heterogenous treatment outcomes. Our mechan...

Haojun Wang, Quanwei Zhou, Ding Fang **e, Qingguo Xu, Tongwang Yang… in Cell Death & Disease (2024)

Article

Hybrid 2D/3D-quantitative structure–activity relationship studies on the bioactivities and molecular mechanism of antibacterial peptides

Antimicrobial peptide (AMP) is the polypeptide, which protects the organism avoiding attack from pathogenic bacteria. Studies have shown that there were some antimicrobial peptides with molecular action mechan...

Qingguo Yan, Fangfang Wang, Bo Zhou, **angna Lin in Amino Acids (2024)

Article

HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis

HOOK3, a member of the human hook microtubule-tethering protein family, has been implicated in the progression of cancer. However, the role of HOOK3 in the pathogenesis of gastric cancer (GC) remains incomplet...

Kexi Yang, Juntao Li, **ghan Zhu, Yuqi Chen, Yuxin He, Jiayu Wang… in Cell Death Discovery (2024)

Article

Production of cello-oligosaccharides from corncob residue by degradation-synthesis reactions

The cellulose-rich corncob residue (CCR) is an abundant and renewable agricultural biomass that has been under-exploited. In this study, two strategies were compared for their ability to transform CCR into cel...

Yazhe Liang, Wangli Ji, **anhua Sun, Zhenzhen Hao… in Applied Microbiology and Biotechnology (2024)

Article

CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis

Cementoblasts on the tooth-root surface are responsible for cementum formation (cementogenesis) and sensitive to Porphyromonas gingivalis stimulation. We have previously proved transcription factor CXXC-type zinc...

Li Ma, Huiyi Wang, **n Huang, Hantao Huang, Yan Peng… in Cell Communication and Signaling (2024)

Article

Identification of the genetic characteristics of copy number variations in experimental specific pathogen-free ducks using whole-genome resequencing

Specific pathogen-free ducks are a valuable laboratory resource for waterfowl disease research and poultry vaccine development. High throughput sequencing allows the systematic identification of structural var...

Lanlan Li, **qiang Quan, Hongyi Liu, Haibo Yu, Hongyan Chen, Changyou **a… in BMC Genomics (2024)

Article

ESRP1-driven alternative splicing of CLSTN1 inhibits the metastasis of gastric cancer

Tumor metastasis severely limits the prognosis of gastric cancer patients. RNA-binding proteins (RBPs) are crucial in tumor metastasis, yet there is limited research into their involvement in gastric cancer. H...

Chengguo Li, Yu** Yin, Ruikang Tao, Yao Lin, Tao Wang, Qian Shen… in Cell Death Discovery (2023)