47 Result(s)

Article

The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif

PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyl...

**aolei Huang, Cheng Zhang, **nci Shang, Yichang Chen, Qin **ao… in Cell Death & Disease (2024)

Article

LAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy

In hepatocellular carcinoma (HCC), immunotherapy is vital for advanced-stage patients. However, diverse individual responses and tumor heterogeneity have resulted in heterogenous treatment outcomes. Our mechan...

Haojun Wang, Quanwei Zhou, Ding Fang **e, Qingguo Xu, Tongwang Yang… in Cell Death & Disease (2024)

Article

Hybrid 2D/3D-quantitative structure–activity relationship studies on the bioactivities and molecular mechanism of antibacterial peptides

Antimicrobial peptide (AMP) is the polypeptide, which protects the organism avoiding attack from pathogenic bacteria. Studies have shown that there were some antimicrobial peptides with molecular action mechan...

Qingguo Yan, Fangfang Wang, Bo Zhou, **angna Lin in Amino Acids (2024)

Article

HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis

HOOK3, a member of the human hook microtubule-tethering protein family, has been implicated in the progression of cancer. However, the role of HOOK3 in the pathogenesis of gastric cancer (GC) remains incomplet...

Kexi Yang, Juntao Li, **ghan Zhu, Yuqi Chen, Yuxin He, Jiayu Wang… in Cell Death Discovery (2024)

Article

ESRP1-driven alternative splicing of CLSTN1 inhibits the metastasis of gastric cancer

Tumor metastasis severely limits the prognosis of gastric cancer patients. RNA-binding proteins (RBPs) are crucial in tumor metastasis, yet there is limited research into their involvement in gastric cancer. H...

Chengguo Li, Yu** Yin, Ruikang Tao, Yao Lin, Tao Wang, Qian Shen… in Cell Death Discovery (2023)

Article

HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification

Aerobic glycolysis has been shown to play a key role in tumor cell proliferation and metastasis. However, how it is directly regulated is largely unknown. Here, we found that HES1 expression was significantly ...

Jiayu Wang, Mengxin Zhu, **ghan Zhu, Juntao Li, **ngchao Zhu… in Cell Death Discovery (2023)

Article

Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells

Brain expressed X-linked gene 2 (BEX2) encoded protein was originally identified to promote transcription by interacting with several transcription factors in the DNA–binding complexes. Recently, BEX2 was found t...

Ning Mu, Yu Wang, **aopeng Li, Zhiyuan Du, Yingdi Wu, Min Su… in Cell Death & Disease (2023)

Article

TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs

Deletion of TRAF2 or TRAF3 in B cells prolongs their survival. However, it remains unknown whether deletion of such factors affects B cells’ ability to tolerate DNA damage, which can be induced by chemotherapeuti...

Monika Vashisht, Huaibin Ge, Jessy John, Harlie A. McKelvey… in Cell Death & Disease (2023)

Article

RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy

Diabetic retinopathy (DR) is a leading cause of blindness that poses significant public health concerns worldwide. Increasing evidence suggests that neuroinflammation plays a key role in the early stages of DR...

Zi**g Huang, Jiajian Liang, Shaolang Chen, Tsz Kin Ng… in Cell Death & Disease (2023)

Article

USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells

Liver fibrosis is a complex fibrotic process that develops early in the course of cirrhosis and is caused by chronic liver damage. The activation of hepatic stellate cells is primarily responsible for the fibr...

**qiu Zhao, Jie Bai, Fengling Peng, Chan Qiu, Yongguo Li, Li Zhong in Cell Death & Disease (2023)

Article

Correction to: MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening

Guangsuo **ng, Zichao Liu, Luyuan Huang, Danyun Zhao… in Cell Death & Differentiation (2022)

Article

Circular RNA circLDLR facilitates cancer progression by altering the miR-30a-3p/SOAT1 axis in colorectal cancer

Colorectal cancer (CRC) is the third most common malignancy worldwide. Circular RNAs (circRNAs) have been reported to play critical regulatory roles in tumorigenesis, serving as tumor biomarkers and therapeuti...

Ruoqin Wang, Jiayu Wang, Yanjun Chen, Yuqi Chen, Qinhua **… in Cell Death Discovery (2022)

Article

LncRNA MEG3 up-regulates SIRT6 by ubiquitinating EZH2 and alleviates nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a global health threat. Here, we presented the significant role of a novel signaling axis comprising long non-coding RNA maternally expressed gene 3 (MEG3), enhancer...

Dongmei Zou, Liang Liu, Yinzhen Zeng, Huanhuan Wang, Dongling Dai… in Cell Death Discovery (2022)

Article

Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma

Tumor heterogeneity has been associated with immunotherapy and targeted drug resistance in hepatocellular carcinoma (HCC). However, communications between tumor and cytotoxic cells are poorly understood to dat...

Yuxue Gao, Qingguo Xu, **nqiang Li, Yuan Guo, Bowen Zhang, Yan **… in Cell Death & Disease (2022)

Article

HOXA-AS2 contributes to regulatory T cell proliferation and immune tolerance in glioma through the miR-302a/KDM2A/JAG1 axis

Long non-coding RNAs (lncRNAs) have been manifested to manipulate diverse biological processes, including tumor-induced immune tolerance. Thus, we aimed in this study to identify the expression pattern of lncR...

Chuanhong Zhong, Bei Tao, **anglong Li, Wei **ang, Lilei Peng… in Cell Death & Disease (2022)

Article

LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance

Aged bone marrow mesenchymal stem cells (BMSCs) exhibit aberrant self-renewal and lineage specification, which contribute to imbalanced bone-fat and progressive bone loss. In addition to known master regulator...

Hengguo Zhang, Rongyao Xu, Bang Li, Zhili **n, Ziji Ling… in Cell Death & Differentiation (2022)