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Article
Does climate change increase the risk of marine toxins? Insights from changing seawater conditions
Marine toxins produced by marine organisms threaten human health and impose a heavy public health burden on coastal countries. Lately, there has been an emergence of marine toxins in regions that were previous...
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Article
Open AccessRolapitant treats lung cancer by targeting deubiquitinase OTUD3
Lung cancer is cancer with the highest morbidity and mortality in the world and poses a serious threat to human health. Therefore, discovering new treatments is urgently needed to improve lung cancer prognosis...
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Article
The cytotoxicity of microcystin-LR: ultrastructural and functional damage of cells
Microcystin-LR (MC-LR) is a toxin produced by cyanobacteria, which is widely distributed in eutrophic water bodies and has multi-organ toxicity. Previous cytotoxicity studies have mostly elucidated the effects...
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Chapter and Conference Paper
RoBrain: Towards Robust Brain-to-Image Reconstruction via Cross-Domain Contrastive Learning
With the development of neuroimaging technology and deep learning methods, neural decoding with functional Magnetic Resonance Imaging (fMRI) of human brain has attracted more and more attention. Neural reconst...
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Article
Open AccessD-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
Age-related hearing loss, known as presbycusis, is the result of auditory system degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and mitochondrial oxidative damage play importa...
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Article
Research advances in identification procedures of endocrine disrupting chemicals
Endocrine disrupting chemicals (EDCs) are increasingly concerned substance endangering human health and environment. However, there is no unified standard for identifying chemicals as EDCs, which is also contr...
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Article
Open AccessDiscovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer
The ubiquitin-proteasome system (UPS) controls protein turnover, and its dysfunction contributes to human diseases including cancer. Deubiquitinating enzymes (DUBs) remove ubiquitin from proteins to maintain t...
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Article
Open AccessThe FACT-targeted drug CBL0137 enhances the effects of rituximab to inhibit B-cell non-Hodgkin’s lymphoma tumor growth by promoting apoptosis and autophagy
Aggressive B-cell non-Hodgkin’s lymphoma (B-NHL) patients often develop drug resistance and tumor recurrence after conventional immunochemotherapy, for which new treatments are needed.
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Chapter and Conference Paper
Mammo-Net: Integrating Gaze Supervision and Interactive Information in Multi-view Mammogram Classification
Breast cancer diagnosis is a challenging task. Recently, the application of deep learning techniques to breast cancer diagnosis has become a popular trend. However, the effectiveness of deep neural networks is...
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Article
Adenovirus-mediated SIRT1 protects cochlear strial marginal cells in a D-gal-induced senescent model in vitro
A primary obstacle in age-related hearing loss (ARHL) study is the lack of accelerated senescent models in vitro that explore the precise underlying mechanism in different types of ARHL. The damage to strial m...
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Article
Open AccessAAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo
Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect against oxidative stress and reducing ATP production to regulate cellul...
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Article
Exploring the Brain-like Properties of Deep Neural Networks: A Neural Encoding Perspective
Nowadays, deep neural networks (DNNs) have been equipped with powerful representation capabilities. The deep convolutional neural networks (CNNs) that draw inspiration from the visual processing mechanism of t...
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Chapter and Conference Paper
Graph Emotion Decoding from Visually Evoked Neural Responses
Brain signal-based affective computing has recently drawn considerable attention due to its potential widespread applications. Most existing efforts exploit emotion similarities or brain region similarities to...
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Article
D-Galactose-Induced Accelerated Aging Model on Auditory Cortical Neurons by Regulating Oxidative Stress and Apoptosis in Vitro
Age-related hearing loss (ARHL) is much more prevalent with age, affecting not only peripheral but central auditory system. We have previously established an aging model of peripheral auditory system in vitro ...
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Article
Open AccessIntegrative analysis and experiments to explore angiogenesis regulators correlated with poor prognosis, immune infiltration and cancer progression in lung adenocarcinoma
Angiogenesis is the process of capillary sprouting from pre-existing vessels and it plays a critical role in the carcinogenic process of lung adenocarcinoma (LUAD). However, the association of angiogenesis reg...
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Article
Open AccessCorrection: The potential role of the HCN1 ion channel and BDNF-mTOR signaling pathways and synaptic transmission in the alleviation of PTSD
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe potential role of the HCN1 ion channel and BDNF-mTOR signaling pathways and synaptic transmission in the alleviation of PTSD
The function of the hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and the expression of brain-derived neurotrophic factor (BDNF) may be involved in the pathogenesis of post-traumatic str...
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Article
Photomultiplication type all-polymer photodetectors with single carrier transport property
Photomultiplication (PM) type all-polymer photodetectors (all-PPDs) are first demonstrated with the sandwich structure of ITO/PEDOT:PSS/PBDB-T:PZ1 (100:x, wt/wt)/Al. The optimal PM type all-PPDs with PBDB-T:PZ1 (...
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Article
Open AccessThe deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
The deubiquitylase OTUD3 plays a suppressive role in breast tumorigenesis through stabilizing PTEN protein, but its role in lung cancer remains unclear. Here, we demonstrate that in vivo deletion of OTUD3 inde...
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Article
Flexible and biocompatible nanopaper-based electrode arrays for neural activity recording
Advances in neural electrode technologies can have a significant impact on both fundamental and applied neuroscience. Here, we report the development of flexible and biocompatible neural electrode arrays based...
