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    Article

    Chinese Society of Cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis

    Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium. It is characterized by acute onset, rapid progress and high risk of death. Its pathogenesis involves excessive immune activation of...

    Jiangang Jiang, Hongyang Shu, Dao Wen Wang, Rutai Hui in Science China Life Sciences (2024)

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    Open Access

    Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca2+]m-PDP1-PDH-histone acetylation retrograde signaling

    Mitochondrial retrograde signaling (mito-RTG) triggered by mitochondrial dysfunction plays a potential role in regulating tumor metabolic reprogramming and cellular sensitivity to radiation. Our previous studi...

    Yingying Shi, You Wang, Huangang Jiang, Xuehua Sun, Hui Xu, Xue Wei in Cell Death & Disease (2021)

  3. Article

    Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases

    Coronavirus disease 2019 (COVID-19) is a global pandemic which has caused numerous deaths worldwide. The present study investigated the roles of hypoproteinemia in the clinical outcome and liver dysfunction of...

    Wei Huang, Chenze Li, Zhiquan Wang, Hong Wang, Ning Zhou in Science China Life Sciences (2020)

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    Article

    Nuclear miR-665 aggravates heart failure via suppressing phosphatase and tensin homolog transcription

    Although numerous miRNAs have been discovered, their functions in the different subcellular organelles have remained obscure. In this study, we found that miR-665 was enriched in the nucleus of cardiomyocytes,...

    Jiahui Fan, Xudong Zhang, **ang Nie, Hua** Li, Shuai Yuan in Science China Life Sciences (2020)

  5. Article

    Open Access

    Comparison of Apolipoprotein B/A1 ratio, Framingham risk score and TC/HDL-c for predicting clinical outcomes in patients undergoing percutaneous coronary intervention

    Apolipoproteins (Apo) are known atherogenic factors that play important roles in many mechanisms related to coronary heart disease (CHD). However, it is unclear whether the apoB/apoA1 ratio is an equal or a be...

    Min Tian, Rui Li, Zhilei Shan, Dao Wen Wang, Jiangang Jiang in Lipids in Health and Disease (2019)

  6. Article

    A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study

    Fulminant myocarditis (FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen (LSBCTR), a completely novel treatment ...

    Sheng Li, Shengyong Xu, Chenze Li, **ao Ran, Guanglin Cui in Science China Life Sciences (2019)

  7. Article

    Open Access

    Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis

    Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as ...

    Daowen Wang, Sheng Li, Jiangang Jiang, Jiangtao Yan in Science China Life Sciences (2019)

  8. No Access

    Article

    Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved

    Endothelial nitric oxide synthase (eNOS) is a key enzyme responsible for the regulation of vascular homeostasis. Many humor factors and mechanical forces can affect eNOS activity via phosphorylation modificati...

    Ruijuan Chen, Jiangang Jiang, **ao **ao in Science in China Series C: Life Sciences (2005)