3,059 Result(s)
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**ng-liang Zhang
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Article
Deuterium distribution and behavior of blisters in pre-damaged and undamaged tungsten
Tungsten (W), as a plasma-facing material, is subjected to high fluence plasma, resulting in both radiation damage and deuterium (D) retention. This study explores the blistering behavior and D supersaturated ...
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Open AccessSafety of embryo cryopreservation: insights from mid-term placental transcriptional changes
In recent years, with benefits from the continuous improvement of clinical technology and the advantage of fertility preservation, the application of embryo cryopreservation has been growing rapidly worldwide....
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Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
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Surface diffraction beamline at the SSRF
BL02U2 of the Shanghai Synchrotron Radiation Facility is a surface diffraction beamline with a photon flux of 5.5 × 1012 photons/s at 10 keV and a beam size of 160 µm × 80 µm at the sample site. It is dedicated t...
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Open AccessExperimental study on the biomechanical stability of complex acetabular fractures in the quadrilateral area: application of a dynamic anterior titanium-plate screw system
Complex acetabular fractures involving quadrilateral areas are more challenging to treat during surgery. To date, there has been no ideal internal fixation for these acetabular fractures. The purpose of this s...
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Open AccessHigh positive predictive value of CNVs detected by clinical exome sequencing in suspected genetic diseases
Genetic disorders often manifest as abnormal fetal or childhood development. Copy number variations (CNVs) represent a significant genetic mechanism underlying such disorders. Despite their importance, the eff...
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Operando measurement of lattice deformation profiles of synchrotron radiation monochromator
This study presents a new method for characterizing the thermal lattice deformation of a monochromator with high precision under service conditions and first reports the operando measurements of nanoscale ther...
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GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resistance and malignancy on the treatment of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Und...
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Open AccessABE-ultramax for high-efficiency biallelic adenine base editing in zebrafish
Advancements in CRISPR technology, particularly the development of base editors, revolutionize genetic variant research. When combined with model organisms like zebrafish, base editors significantly accelerate...
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Article
Open AccessEnhancing efficiency of protein language models with minimal wet-lab data through few-shot learning
Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Pre-trained protein language models have achieved state-of-the-art performance in predicting protein fitness w...
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Open AccessNon-Abelian braiding of Fibonacci anyons with a superconducting processor
Quantum many-body systems with a non-Abelian topological order can host anyonic quasiparticles. It has been proposed that anyons could be used to encode and manipulate information in a topologically protected ...
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Article
Transcatheter Arterial Embolization with Bleomycin-Lipiodol of Hepatic Hemangiomas: Safety, Efficacy and Predictors of Response
To evaluate the safety, efficacy and predictors of response of transcatheter arterial embolization (TAE) to treat hepatic hemangiomas (HHs).
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Article
Sustainably releasing osteogenic trace elements from montmorillonite intercalated hybrid nanocomposites accelerates bone regeneration
Optimizing scaffold components and architectures to achieve endogenous osteogenesis is a prospective advancement for bone tissue engineering. Here, montmorillonite was introduced as a reinforcing phase into a ...
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Article
Foxg1 Modulation of the Prkcd Gene in the Lateral Habenula Mediates Trigeminal Neuralgia-Associated Anxiety-Like Behaviors in Mice
Trigeminal Neuralgia (TN) is a debilitating disorder frequently accompanied by mood complications such as depression and anxiety. The current study sought to elucidate the molecular underpinnings that contribu...
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Surface-derived phosphate layer on NiFe-layered double hydroxide realizes stable seawater oxidation at the current density of 1 A°cm−2
Seawater electrolysis, especially in coastlines, is widely considered as a sustainable way of making clean and high-purity H2 from renewable energy; however, the practical viability is challenged severely by the ...
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Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65−/−) mice exhibit a...
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Open AccessPost-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment
Post-sepsis psychiatric disorder, encompassing anxiety, depression, post-traumatic stress disorder and delirium, is a highly prevalent complication secondary to sepsis, resulting in a marked increase in long-t...
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Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
Status epilepticus (SE), a serious and often life-threatening medical emergency, is characterized by abnormally prolonged seizures. It is not effectively managed by present first-line anti-seizure medications ...
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Self-powered and charge-transport-layer-free photodetectors based on chloride treated perovskites for weak light detection
Organic-inorganic halide perovskite materials have been widely used in photodetectors (PDs) for the solution processability and outstanding optoelectronic characteristics. However, conventional perovskite-base...
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Microstructural evolution, mechanical properties and degradation mechanism of PS-PVD quasi-columnar thermal barrier coatings exposed to glassy CMAS deposits
Thermal barrier coatings (TBCs) applied in aero-engines tend to be attacked by molten calcia-magnesia-alumino-silicate (CMAS) at high operating temperatures. Yttria-stabilized zirconia (YSZ) coatings with quas...
