302 Result(s)

Article

Nicotinamide riboside restores nicotinamide adenine dinucleotide levels and alleviates brain injury by inhibiting oxidative stress and neuroinflammation in a mouse model of intracerebral hemorrhage

Hemorrhagic stroke is a global health problem owing to its high morbidity and mortality rates. Nicotinamide riboside is an important precursor of nicotinamide adenine dinucleotide characterized by a high bioav...

**g She, Hua Zhang, Hui Xu, Yan-Yan Li, Jun-Chao Wu, Rong Han… in Molecular Neurobiology (2024)

Article

Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages

Worldwide, more than 125 million people are infected with Shigella each year and develop shigellosis. In our previous study, we provided evidence that Shigella sonnei infection triggers activation of the NACHT, L...

Kuo-Feng Hua, Yu-Bei Lin, Hsiao-Wen Chiu, Wei-Ting Wong… in Journal of Inflammation (2024)

Article

Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer

Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but fe...

Yue Zeng, Chun-Hong Hu, Yi-Zheng Li, Jian-Song Zhou, Shu-**ng Wang… in Nature Medicine (2024)

Article

CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis

The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_0007088) was identified as overexpressed in HCC cases through bioinformatics analysis. This ...

**ao-Yu Zhang, Shan-Shan Li, Yu-Rong Gu, Le-**n **ao, **n-Yi Ma… in Molecular Cancer (2024)

Article

Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

**ang-Ning Meng, **-Fa Ma, Yang-He Liu, Si-Qing Li, Xu Wang… in British Journal of Cancer (2024)

Article

Comprehensive evaluation of serum hepatic proteins in predicting prognosis among cancer patients with cachexia: an observational cohort study

Hepatic proteins, including albumin, prealbumin, and transferrin have been confirmed to be prognostic predictors in various cancers. This study aimed to comprehensively assess the prognostic value of these thr...

Jia-**n Huang, ** Zhang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li… in BMC Cancer (2024)

Article

The impact of squamous cell transformation on the prognosis of patients treated with radical nephroureterectomy

Limited information is available for guiding the management of upper urinary tract (UUT) urothelial carcinoma with squamous differentiation (UC-SqD). We did not even know about the difference between pure uro...

Li-Hua Huang, Chuan-Shu Chen, Jian-Ri Li, Kun-Yuan Chiu, Shian-Shiang Wang… in BMC Cancer (2024)

Article

Epidemiology and outcomes of multidrug-resistant bacterial infection in non-cystic fibrosis bronchiectasis

Multidrug-resistant (MDR) bacteria impose a considerable health-care burden and are associated with bronchiectasis exacerbation. This study investigated the clinical outcomes of adult patients with bronchiecta...

Chih-Hao Chang, Chiung-Hsin Chang… in Annals of Clinical Microbiology and Antimi… (2024)

Article

Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection

Previous studies have shown that changes in the microbial community of the female urogenital tract are associated with Human papillomavirus (HPV) infection. However, research on this association was mostly foc...

Yong-Hong Dong, Yu-Hua Luo, Chen-Jian Liu… in Journal of Translational Medicine (2024)

Article

Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia

The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI...

Guo-Tian Ruan, Li Deng, Hai-Lun **e, **-Yu Shi, **ao-Yue Liu… in Cancer & Metabolism (2024)

Article

The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma by promoting vimentin degradation

Metastasis has emerged as the major reason of treatment failure and mortality in patients with nasopharyngeal carcinoma (NPC). Growing evidence links abnormal DNA methylation to the initiation and progression ...

Shi-Qing Zhou, ** Feng, Ming-Liang Ye… in Journal of Experimental & Clinical Cancer … (2024)

Article

Therapeutic challenges in peripheral T-cell lymphoma

Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of hematological malignancies. Compared to our knowledge of B-cell tumors, our understanding of T-cell leukemia and lymphoma remains less adv...

Yunpeng Luan, **ang Li, Yunqi Luan, Junyu Luo, Qinzuo Dong, Shili Ye… in Molecular Cancer (2024)

Article

Publisher Correction to: RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN

Bin Wang, Zhong-Hua Wu, **-Yang Lou, Chang Chai, Shuang-Yin Han… in Cellular Oncology (2023)

Article

Quality assurance in a phase III, multicenter, randomized trial of POstmastectomy radioThErapy in Node posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a planning benchmark case

To report the planning benchmark case results of the POTENTIAL trial—a multicenter, randomized, phase 3 trial—to evaluate the value of internal mammary nodal (IMN) irradiation for patients with high-risk breas...

Yu-Chun Song, Zhi-Hui Hu, Xue-Na Yan, Hui Fang, Yu Tang, Hao **g… in Radiation Oncology (2023)

Article

Interplay between lncRNA RP11-367G18.1 variant 2 and YY1 plays a vital role in hypoxia-mediated gene expression and tumorigenesis

The hypoxia-responsive long non-coding RNA, RP11-367G18.1, has recently been reported to induce histone 4 lysine 16 acetylation (H4K16Ac) through its variant 2; however, the underlying molecular mechanism remains...

Pei-Hua Peng, Ji-Lin Chen, Heng-Hsiung Wu, Wen-Hao Yang… in Cancer Cell International (2023)

Article

Abnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG

The role of PRKAG2 in the maintenance of heart function is well established, but little is known about how PRKAG2 is regulated in cardiomyocytes. In this study, we investigated the role of the lncRNA PRKAG2-AS, w...

**ao-Wei Song, Ting Su, Bo Li, Yun-Jie Huang, Wen-**a He… in Clinical Epigenetics (2023)

Article

Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Nick Shrine, Abril G. Izquierdo, **g Chen, Richard Packer… in Nature Genetics (2023)

Article

Prevalence and genomic analysis of t203-like G9 (G9-VI) rotaviruses circulating in children with gastroenteritis in Bei**g, China

Our previous surveillance revealed that t203-like G9 (tentatively designated subtype G9-VI) rotaviruses re-emerged in 2010 in Bei**g and rapidly prevailed over the G9-III subtype (the most common G9 subtype g...

Hui-** Dong, Li-Ying Liu, Li-** Jia, Lin-Qing Zhao, Feng-Hua **… in Archives of Virology (2023)

Article

Immune cell profiles of idiopathic inflammatory myopathy patients expressed anti-aminoacyl tRNA synthetase or anti-melanoma differentiation-associated gene 5 autoantibodies

Patients with idiopathic inflammatory myopathy (IIM) often express a different type of myositis-specific autoantibodies (MSAs), each associated with different clinical symptoms. Understanding the immunopathoge...

Joung-Liang Lan, Shih-Hsin Chang, Gregory J. Tsay, Der-Yuan Chen… in BMC Immunology (2023)

Article

Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression

The catenin beta 1 gene (CTNNB1) plays a crucial role in the malignant progression of various cancers. Recent studies have suggested that CTNNB1 hyperactivation is closely related to the occurrence and develop...

Tao Liu, Meng-Qi Fan, **ao-**ao **e, Qi-Peng Shu… in Journal of Translational Medicine (2023)