63 Result(s)

Article

Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages

Worldwide, more than 125 million people are infected with Shigella each year and develop shigellosis. In our previous study, we provided evidence that Shigella sonnei infection triggers activation of the NACHT, L...

Kuo-Feng Hua, Yu-Bei Lin, Hsiao-Wen Chiu, Wei-Ting Wong… in Journal of Inflammation (2024)

Article

Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1

Psychological stress increases the susceptibility to herpes simplex virus type 1 (HSV-1) infection. There is no effective intervention due to the unknown pathogenesis mechanisms. In this study we explored the ...

**g-yu Weng, **n-xing Chen, **ao-hua Wang, Hui-er Ye… in Acta Pharmacologica Sinica (2023)

Article

Author Correction: Wogonin suppresses osteopontin expression in adipocytes by activating PPARα

Ye-min Zhang, Ming-xin Li, Zhao Tang, Chang-hua Wang in Acta Pharmacologica Sinica (2023)

Article

Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors

Guo-zhen Cao, Li-ying Ma, Zong-hui Zhang, **ao-lin Wang… in Acta Pharmacologica Sinica (2023)

Article

Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects

VV116 (JT001) is an oral drug candidate of nucleoside analog against SARS-CoV-2. The purpose of the three phase I studies was to evaluate the safety, tolerability, and pharmacokinetics of single and multiple a...

Hong-jie Qian, Yu Wang, Meng-qi Zhang, Yuan-chao **e… in Acta Pharmacologica Sinica (2022)

Article

NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury

Acute kidney injury (AKI) with maladaptive tubular repair leads to renal fibrosis and progresses to chronic kidney disease (CKD). At present, there is no curative drug to interrupt AKI-to-CKD progression. The ...

Zhi-yong **e, Wei Dong, Li Zhang, Meng-jie Wang… in Acta Pharmacologica Sinica (2022)

Article

Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome

The multi-generation heredity trait of hypertension in human has been reported, but the molecular mechanisms underlying multi-generational inheritance of hypertension remain obscure. Recent evidence shows that...

**ao Guan, Guo-rong Dan, Yao Yang, Yan Ji, Wen-**g Lai… in Acta Pharmacologica Sinica (2022)

Article

Identification of SARS-CoV-2 entry inhibitors among already approved drugs

To discover effective drugs for COVID-19 treatment amongst already clinically approved drugs, we developed a high throughput screening assay for SARS-CoV-2 virus entry inhibitors using SARS2-S pseudotyped viru...

Li Yang, Rong-juan Pei, Heng Li, **n-na Ma, Yu Zhou… in Acta Pharmacologica Sinica (2021)

Article

(5R)-5-hydroxytriptolide ameliorates anti-glomerular basement membrane glomerulonephritis in NZW mice by regulating Fcγ receptor signaling

(5R)-5-hydroxytriptolide (LLDT-8) is a novel triptolide analog that has been identified as a promising candidate for treating autoimmune diseases and has been shown to be effective in treating murine collagen-ind...

Qing Qi, Heng Li, Ze-min Lin, **ao-qian Yang, Feng-hua Zhu… in Acta Pharmacologica Sinica (2018)

Article

Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy

Poly (ADP-ribose) polymerase 1 (PARP1) is overexpressed in a variety of cancers, especially in breast and ovarian cancers; tumor cells that are deficient in breast cancer gene 1/2 (BRCA1/2) are highly sensitive t...

Wen-hua Chen, Shan-shan Song, Ming-hui Qi, **a-juan Huan… in Acta Pharmacologica Sinica (2017)

Article

Autophagy inhibitor 3-methyladenine alleviates overload-exercise-induced cardiac injury in rats

Overload-exercise (OE) causes myocardial injury through inducing autophagy and apoptosis. In this study we examined whether an autophagy inhibitor 3-methyladenine (3-MA) could alleviate OE-induced cardiac inju...

Hua Liu, Hui Lei, Yue Shi, **-ju Wang, Ning Chen… in Acta Pharmacologica Sinica (2017)

Article

Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf^V600E inhibitors

The mutation of B-Raf^V600E is widespread in a variety of human cancers. Its inhibitors vemurafenib and dabrafenib have been launched as drugs for treating unresectable melanoma, demonstrating that B-Raf^V600E is a...

Gui-min Wang, **ang Wang, Jian-ming Zhu, Bin-bin Guo… in Acta Pharmacologica Sinica (2017)

Article

The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer

Long non-coding RNAs (lncRNAs) are associated with the occurrence, development and prognoses of non-small cell lung cancer (NSCLC). In the present study, we investigated the functional mechanisms of the lncRNA...

Ya-long Zhang, Xue-bing Li, Yan-xu Hou, Nian-zhen Fang… in Acta Pharmacologica Sinica (2017)

Article

Erratum: The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer

Zhang YL, Li XB, Hou YX, Fang NZ, You JC, Zhou QH. Acta Pharmacol Sin 2017; 38: advanced online publication, 2 Jan 2017. The original version of this article was incorrectly given doi “10.1038/aps.2016.132”, w...

Ya-long Zhang, Xue-bing Li, Yan-xu Hou, Nian-zhen Fang… in Acta Pharmacologica Sinica (2017)

Article

Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment

Human enterovirus 71 (EV71) is the primary causative agent of recent large-scale outbreaks of hand, foot, and mouth disease (HFMD) in Asia. Currently, there are no drugs available for the prevention and treatm...

Ting Zhong, Li-ying Zhang, Zeng-yan Wang, Yue Wang… in Acta Pharmacologica Sinica (2017)

Article

Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition

C/EBP homologous protein (CHOP) is a transcription factor that is activated at multiple levels during ER stress and plays an important role in ER stress-induced apoptosis. In this study we identified a novel C...

Yi-ming Ma, Yan-min Peng, Qiong-hua Zhu, An-hui Gao, Bo Chao… in Acta Pharmacologica Sinica (2016)

Article

Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway

Major depressive disorder (MDD) is a debilitating mental disorder associated with dysfunction of the neurotransmitter-neuroendocrine system and neuroinflammatory responses. Salvianolic acid B (SalB) has shown ...

**-qiang Zhang, **ao-hui Wu, Yi Feng, **ao-fang **e… in Acta Pharmacologica Sinica (2016)

Article

Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways

Chinese medicine CGA formula consists of polysaccharide from Cordyceps sinensis mycelia (CS-PS), gypenosides and amygdalin, which is derived from Fuzheng Huayu (FZHY) capsule for treating liver fibrosis. In this ...

Xue-mei Li, **g-hua Peng, Zhao-lin Sun, Hua-jie Tian… in Acta Pharmacologica Sinica (2016)

Article

An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s

The substrate cocktail is frequently used to evaluate cytochrome P450 (CYP) enzyme-mediated drug interactions and potential interactions among the probe substrates. Here, we re-optimized the substrate cocktail...

Zhong-hua Chen, Su-xing Zhang, Na Long, Li-shan Lin, Tao Chen… in Acta Pharmacologica Sinica (2016)

Article

Argonaute 2 promotes angiogenesis via the PTEN/VEGF signaling pathway in human hepatocellular carcinoma

Argonaute2 (AGO2) protein is the active part of RNA-induced silencing complex, cleaving the target mRNA strand complementary to their bound siRNA. An increasing number of miRNAs has been identified as essentia...

Zhen-long Ye, Yao Huang, Lin-fang Li, Hai-li Zhu, Hai-xia Gao… in Acta Pharmacologica Sinica (2015)