110 Result(s)

Article

CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis

The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_0007088) was identified as overexpressed in HCC cases through bioinformatics analysis. This ...

**ao-Yu Zhang, Shan-Shan Li, Yu-Rong Gu, Le-**n **ao, **n-Yi Ma… in Molecular Cancer (2024)

Article

Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

**ang-Ning Meng, **-Fa Ma, Yang-He Liu, Si-Qing Li, Xu Wang… in British Journal of Cancer (2024)

Article

Comprehensive evaluation of serum hepatic proteins in predicting prognosis among cancer patients with cachexia: an observational cohort study

Hepatic proteins, including albumin, prealbumin, and transferrin have been confirmed to be prognostic predictors in various cancers. This study aimed to comprehensively assess the prognostic value of these thr...

Jia-**n Huang, ** Zhang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li… in BMC Cancer (2024)

Article

The impact of squamous cell transformation on the prognosis of patients treated with radical nephroureterectomy

Limited information is available for guiding the management of upper urinary tract (UUT) urothelial carcinoma with squamous differentiation (UC-SqD). We did not even know about the difference between pure uro...

Li-Hua Huang, Chuan-Shu Chen, Jian-Ri Li, Kun-Yuan Chiu, Shian-Shiang Wang… in BMC Cancer (2024)

Article

Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia

The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI...

Guo-Tian Ruan, Li Deng, Hai-Lun **e, **-Yu Shi, **ao-Yue Liu… in Cancer & Metabolism (2024)

Article

The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma by promoting vimentin degradation

Metastasis has emerged as the major reason of treatment failure and mortality in patients with nasopharyngeal carcinoma (NPC). Growing evidence links abnormal DNA methylation to the initiation and progression ...

Shi-Qing Zhou, ** Feng, Ming-Liang Ye… in Journal of Experimental & Clinical Cancer … (2024)

Article

Therapeutic challenges in peripheral T-cell lymphoma

Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of hematological malignancies. Compared to our knowledge of B-cell tumors, our understanding of T-cell leukemia and lymphoma remains less adv...

Yunpeng Luan, **ang Li, Yunqi Luan, Junyu Luo, Qinzuo Dong, Shili Ye… in Molecular Cancer (2024)

Article

Publisher Correction to: RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN

Bin Wang, Zhong-Hua Wu, **-Yang Lou, Chang Chai, Shuang-Yin Han… in Cellular Oncology (2023)

Article

Quality assurance in a phase III, multicenter, randomized trial of POstmastectomy radioThErapy in Node posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a planning benchmark case

To report the planning benchmark case results of the POTENTIAL trial—a multicenter, randomized, phase 3 trial—to evaluate the value of internal mammary nodal (IMN) irradiation for patients with high-risk breas...

Yu-Chun Song, Zhi-Hui Hu, Xue-Na Yan, Hui Fang, Yu Tang, Hao **g… in Radiation Oncology (2023)

Article

Risk of temporal lobe necrosis between proton beam and volumetric modulated arc therapies in patients with different head and neck cancers

To investigate the frequency of temporal lobe necrosis (TLN) soon after radiotherapy (RT) and identify differences among patients with various types of head and neck cancer (HNC) and between different RT methods.

Chi-Hung Liu, Chien-Yu Lin, Bing-Shen Huang, Yi-Chia Wei… in Radiation Oncology (2023)

Article

Early relapse is an adverse prognostic factor for survival outcomes in patients with oral cavity squamous cell carcinoma: results from a nationwide registry study

The prognostic significance of the relapse interval in patients with resected oral cavity squamous cell carcinoma (OCSCC) is a matter of ongoing debate. In this large-scale, registry-based, nationwide study, w...

Chi-Ying Tsai, Yu-Wen Wen, Shu-Ru Lee, Shu-Hang Ng, Chung-Jan Kang, Li-Yu Lee… in BMC Cancer (2023)

Article

The expression characteristics and clinical significance of ACP6, a potential target of nitidine chloride, in hepatocellular carcinoma

Acid phosphatase type 6 (ACP6) is a mitochondrial lipid phosphate phosphatase that played a role in regulating lipid metabolism and there is still blank in the clinico-pathological significance and functional ...

Li Gao, Dan-Dan **ong, **a Yang, Jian-Di Li, Rong-Quan He, Zhi-Guang Huang… in BMC Cancer (2022)

Article

An effective and chemotherapy-free strategy of all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia in all risk groups (APL15 trial)

The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has been demonstrated to have comparable effectiveness or better to ATRA and chemotherapy (CHT) in non-high-risk acute promyelocytic...

Huai-Yu Wang, Sha Gong, Guo-Hui Li, Ya-Zhou Yao, Yin-Suo Zheng… in Blood Cancer Journal (2022)

Article

Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

Exosomes are well-known key mediators of intercellular communication and contribute to various physiological and pathological processes. Their biogenesis involves four key steps, including cargo sorting, MVB f...

Qing-Fang Han, Wen-Jia Li, Kai-Shun Hu, Jie Gao, Wen-Long Zhai… in Molecular Cancer (2022)

Article

Comparison of response evaluation criteria in solid tumors and tumor regression grade in evaluating the effect of preoperative systemic therapy of gastric cancer

Both Response Evaluation Criteria in Solid Tumors (RECIST) and tumor regression grade (TRG) play key roles in evaluating tumor response. We analyzed the consistency of TRG and RECIST 1.1 for gastric cancer (GC...

Ming-Yu Lai, Shi-Yang Kang, Yu-Ting Sun, Ting-Ting Quan, Shi-Xun Lu… in BMC Cancer (2022)

Article

Apatinib plus vinorelbine versus vinorelbine for metastatic triple-negative breast cancer who failed first/second-line treatment: the NAN trial

While therapies such as chemotherapy combined with immunotherapy, sacituzumab govitecan, and PARP inhibitors are available for metastatic TNBC, on disease progression after these therapies, the mainstay of the...

Dou-Dou Li, Zhong-hua Tao, Bi-Yun Wang, Lei-** Wang, Jun Cao… in npj Breast Cancer (2022)

Article

Clinical significance and potential regulatory mechanism of overexpression of pituitary tumor-transforming gene transcription factor in bladder cancer

Pituitary tumor transforming gene-1 (PTTG1) transcription factor is identified as carcinogenic and associated with tumor invasiveness, but its role in bladder cancer (BLCA) remains obscure. This research is in...

Jian-Di Li, Abdirahman Ahmed Farah, Zhi-Guang Huang, Gao-Qiang Zhai… in BMC Cancer (2022)

Article

Prognostic importance of systemic inflammation and insulin resistance in patients with cancer: a prospective multicenter study

Systemic inflammation and insulin resistance (IR) are often associated with poor prognosis in cancer. This study aimed to investigate the prognostic value of surrogate systemic inflammation and IR indices in p...

Guo-Tian Ruan, Hai-Lun **e, Yi-Zhen Gong, Yi-Zhong Ge, Qi Zhang, Zi-Wen Wang… in BMC Cancer (2022)

Article

Correction: A novel approach for relapsed/refractory FLT3^mut+acute myeloid leukaemia: synergistic effect of the combination of bispecific FLT3scFv/NKG2D-CAR T cells and gilteritinib

Ke-xin Li, Hui-yang Wu, Wan-ying Pan, Meng-qi Guo, De-zhi Qiu… in Molecular Cancer (2022)

Article

Reprogramming the tumor microenvironment by genome editing for precision cancer therapy

The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays essential roles in tumor development and metastasis. The clinical outcomes of tumors are often closely related to indivi...

Ke Liu, Jia-Jia Cui, Yan Zhan, Qian-Ying Ouyang, Qi-Si Lu… in Molecular Cancer (2022)