92 Result(s)

Article

Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages

Worldwide, more than 125 million people are infected with Shigella each year and develop shigellosis. In our previous study, we provided evidence that Shigella sonnei infection triggers activation of the NACHT, L...

Kuo-Feng Hua, Yu-Bei Lin, Hsiao-Wen Chiu, Wei-Ting Wong… in Journal of Inflammation (2024)

Article

The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma by promoting vimentin degradation

Metastasis has emerged as the major reason of treatment failure and mortality in patients with nasopharyngeal carcinoma (NPC). Growing evidence links abnormal DNA methylation to the initiation and progression ...

Shi-Qing Zhou, ** Feng, Ming-Liang Ye… in Journal of Experimental & Clinical Cancer … (2024)

Article

Immune cell profiles of idiopathic inflammatory myopathy patients expressed anti-aminoacyl tRNA synthetase or anti-melanoma differentiation-associated gene 5 autoantibodies

Patients with idiopathic inflammatory myopathy (IIM) often express a different type of myositis-specific autoantibodies (MSAs), each associated with different clinical symptoms. Understanding the immunopathoge...

Joung-Liang Lan, Shih-Hsin Chang, Gregory J. Tsay, Der-Yuan Chen… in BMC Immunology (2023)

Article

Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1

Psychological stress increases the susceptibility to herpes simplex virus type 1 (HSV-1) infection. There is no effective intervention due to the unknown pathogenesis mechanisms. In this study we explored the ...

**g-yu Weng, **n-xing Chen, **ao-hua Wang, Hui-er Ye… in Acta Pharmacologica Sinica (2023)

Article

Author Correction: Wogonin suppresses osteopontin expression in adipocytes by activating PPARα

Ye-min Zhang, Ming-xin Li, Zhao Tang, Chang-hua Wang in Acta Pharmacologica Sinica (2023)

Article

Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors

Guo-zhen Cao, Li-ying Ma, Zong-hui Zhang, **ao-lin Wang… in Acta Pharmacologica Sinica (2023)

Article

Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects

VV116 (JT001) is an oral drug candidate of nucleoside analog against SARS-CoV-2. The purpose of the three phase I studies was to evaluate the safety, tolerability, and pharmacokinetics of single and multiple a...

Hong-jie Qian, Yu Wang, Meng-qi Zhang, Yuan-chao **e… in Acta Pharmacologica Sinica (2022)

Article

NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury

Acute kidney injury (AKI) with maladaptive tubular repair leads to renal fibrosis and progresses to chronic kidney disease (CKD). At present, there is no curative drug to interrupt AKI-to-CKD progression. The ...

Zhi-yong **e, Wei Dong, Li Zhang, Meng-jie Wang… in Acta Pharmacologica Sinica (2022)

Article

Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome

The multi-generation heredity trait of hypertension in human has been reported, but the molecular mechanisms underlying multi-generational inheritance of hypertension remain obscure. Recent evidence shows that...

**ao Guan, Guo-rong Dan, Yao Yang, Yan Ji, Wen-**g Lai… in Acta Pharmacologica Sinica (2022)

Article

Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway

Cancer cells have an imbalance in oxidation-reduction (redox) homeostasis. Understanding the precise mechanisms and the impact of the altered redox microenvironment on the immunologic reaction to tumors is lim...

**ang Li, Shaomin Wang, Wei Mu… in Journal of Experimental & Clinical Cancer … (2022)

Article

MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling

Cell invasion is a hallmark of metastatic cancer, leading to unfavorable clinical outcomes. In this study, we established two highly invasive lung cancer cell models (A549-i8 and H1299-i8) and identified mesod...

Yang Wang, **g Zhang, Yang-Jia Li… in Journal of Experimental & Clinical Cancer … (2021)

Article

Identification of SARS-CoV-2 entry inhibitors among already approved drugs

To discover effective drugs for COVID-19 treatment amongst already clinically approved drugs, we developed a high throughput screening assay for SARS-CoV-2 virus entry inhibitors using SARS2-S pseudotyped viru...

Li Yang, Rong-juan Pei, Heng Li, **n-na Ma, Yu Zhou… in Acta Pharmacologica Sinica (2021)

Article

Correction to: Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression

Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu… in Journal of Experimental & Clinical Cancer … (2021)

Article

Correction to: Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma

Xue Zhang, Qiao-Li LV, Yuan-Tao Huang… in Journal of Experimental & Clinical Cancer … (2021)

Article

Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma

Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood. This study aimed to investigate the fun...

**ao Yang, Jia-shun Wu, Mao Li… in Journal of Experimental & Clinical Cancer … (2021)

Article

Long noncoding RNA UPK1A-AS1 indicates poor prognosis of hepatocellular carcinoma and promotes cell proliferation through interaction with EZH2

Dysregulation of long non-coding RNAs (lncRNAs) is responsible for cancer initiation and development, positioning lncRNAs as not only biomarkers but also promising therapeutic targets for cancer treatment. A g...

Dong-Yan Zhang, Qing-Can Sun, Xue-**g Zou… in Journal of Experimental & Clinical Cancer … (2020)

Article

Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging miR-143-3p and PCBP1

Circular RNAs (circRNAs) play a critical regulatory role in cancer progression. However, the underlying mechanisms of circRNAs in hepatocellular carcinoma (HCC) metastasis remain mostly unknown.

Li-na Song, Guang-lei Qiao, Jian Yu… in Journal of Experimental & Clinical Cancer … (2020)

Article

Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis

Exosomes play crucial roles in regulating the crosstalk between normal and cancer cells in the tumor microenvironment, and in regulating cancer proliferation, migration and invasion through their cargo molecules.

**u-Yan Huang, Zi-Li Huang, ** Huang… in Journal of Experimental & Clinical Cancer … (2020)

Article

Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis

The Slug-E-cadherin axis plays a critical role in non-small-cell lung cancers (NSCLCs) where aberrant upregulation of Slug promotes cancer metastasis. Now, the post-translational modifications of Slug and thei...

Pei-Fang Hung, Tse-Ming Hong… in Journal of Experimental & Clinical Cancer … (2019)

Article

Transmembrane protein GRINA modulates aerobic glycolysis and promotes tumor progression in gastric cancer

Recent observations indicate a decreased cancer risk in patients with Alzheimer’s disease (AD). AD is a severe neurodegenerative disorder characterized by progressive cognitive decline. The 8q24 region has bee...

Dan-Hua Xu, Qing Li, Hao Hu, Bo Ni, Xu Liu… in Journal of Experimental & Clinical Cancer … (2018)