172 Result(s)

Article

Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer

Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but fe...

Yue Zeng, Chun-Hong Hu, Yi-Zheng Li, Jian-Song Zhou, Shu-**ng Wang… in Nature Medicine (2024)

Article

Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

**ang-Ning Meng, **-Fa Ma, Yang-He Liu, Si-Qing Li, Xu Wang… in British Journal of Cancer (2024)

Article

Comprehensive evaluation of serum hepatic proteins in predicting prognosis among cancer patients with cachexia: an observational cohort study

Hepatic proteins, including albumin, prealbumin, and transferrin have been confirmed to be prognostic predictors in various cancers. This study aimed to comprehensively assess the prognostic value of these thr...

Jia-**n Huang, ** Zhang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li… in BMC Cancer (2024)

Article

The impact of squamous cell transformation on the prognosis of patients treated with radical nephroureterectomy

Limited information is available for guiding the management of upper urinary tract (UUT) urothelial carcinoma with squamous differentiation (UC-SqD). We did not even know about the difference between pure uro...

Li-Hua Huang, Chuan-Shu Chen, Jian-Ri Li, Kun-Yuan Chiu, Shian-Shiang Wang… in BMC Cancer (2024)

Article

Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection

Previous studies have shown that changes in the microbial community of the female urogenital tract are associated with Human papillomavirus (HPV) infection. However, research on this association was mostly foc...

Yong-Hong Dong, Yu-Hua Luo, Chen-Jian Liu… in Journal of Translational Medicine (2024)

Article

Publisher Correction to: RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN

Bin Wang, Zhong-Hua Wu, **-Yang Lou, Chang Chai, Shuang-Yin Han… in Cellular Oncology (2023)

Article

Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Nick Shrine, Abril G. Izquierdo, **g Chen, Richard Packer… in Nature Genetics (2023)

Article

Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression

The catenin beta 1 gene (CTNNB1) plays a crucial role in the malignant progression of various cancers. Recent studies have suggested that CTNNB1 hyperactivation is closely related to the occurrence and develop...

Tao Liu, Meng-Qi Fan, **ao-**ao **e, Qi-Peng Shu… in Journal of Translational Medicine (2023)

Article

Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1

Psychological stress increases the susceptibility to herpes simplex virus type 1 (HSV-1) infection. There is no effective intervention due to the unknown pathogenesis mechanisms. In this study we explored the ...

**g-yu Weng, **n-xing Chen, **ao-hua Wang, Hui-er Ye… in Acta Pharmacologica Sinica (2023)

Article

Suppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors

As the most lethal gynecologic cancer, ovarian cancer (OV) holds the potential of being immunotherapy-responsive. However, only modest therapeutic effects have been achieved by immunotherapies such as immune c...

Dong Yang, Mei-Han Duan, Qiu-Er Yuan, Zhi-Ling Li… in Journal of Translational Medicine (2023)

Article

Author Correction: Wogonin suppresses osteopontin expression in adipocytes by activating PPARα

Ye-min Zhang, Ming-xin Li, Zhao Tang, Chang-hua Wang in Acta Pharmacologica Sinica (2023)

Article

Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors

Guo-zhen Cao, Li-ying Ma, Zong-hui Zhang, **ao-lin Wang… in Acta Pharmacologica Sinica (2023)

Article

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising ...

Nick Shrine, Abril G. Izquierdo, **g Chen, Richard Packer… in Nature Genetics (2023)

Article

Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law… in Nature Genetics (2023)

Article

ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking

Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atherosclerotic cardiovascular diseases and serum lipoprotein levels. However, how RRBP1 regulates blood...

Chu-Hsuan Chiu, Chin-Feng Hsuan, Shih-Hua Lin, Yi-Jen Hung… in Journal of Biomedical Science (2023)

Article

Early relapse is an adverse prognostic factor for survival outcomes in patients with oral cavity squamous cell carcinoma: results from a nationwide registry study

The prognostic significance of the relapse interval in patients with resected oral cavity squamous cell carcinoma (OCSCC) is a matter of ongoing debate. In this large-scale, registry-based, nationwide study, w...

Chi-Ying Tsai, Yu-Wen Wen, Shu-Ru Lee, Shu-Hang Ng, Chung-Jan Kang, Li-Yu Lee… in BMC Cancer (2023)

Article

A machine learning framework develops a DNA replication stress model for predicting clinical outcomes and therapeutic vulnerability in primary prostate cancer

Recent studies have identified DNA replication stress as an important feature of advanced prostate cancer (PCa). The identification of biomarkers for DNA replication stress could therefore facilitate risk stra...

Rong-Hua Huang, Ying-Kai Hong, Heng Du, Wei-Qi Ke… in Journal of Translational Medicine (2023)

Article

Interruption of the long non-coding RNA HOTAIR signaling axis ameliorates chemotherapy-induced cachexia in bladder cancer

Cisplatin-based chemotherapy is the first line of treatment for bladder cancer. However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia. HOTAIR, an oncogenic long non-coding RNA (ln...

Che-Yuan Hu, Bing-Hua Su, Ya-Che Lee, Chung-Teng Wang… in Journal of Biomedical Science (2022)

Article

The expression characteristics and clinical significance of ACP6, a potential target of nitidine chloride, in hepatocellular carcinoma

Acid phosphatase type 6 (ACP6) is a mitochondrial lipid phosphate phosphatase that played a role in regulating lipid metabolism and there is still blank in the clinico-pathological significance and functional ...

Li Gao, Dan-Dan **ong, **a Yang, Jian-Di Li, Rong-Quan He, Zhi-Guang Huang… in BMC Cancer (2022)

Article

Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects

VV116 (JT001) is an oral drug candidate of nucleoside analog against SARS-CoV-2. The purpose of the three phase I studies was to evaluate the safety, tolerability, and pharmacokinetics of single and multiple a...

Hong-jie Qian, Yu Wang, Meng-qi Zhang, Yuan-chao **e… in Acta Pharmacologica Sinica (2022)