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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
Experimental quantum computational chemistry with optimized unitary coupled cluster ansatz
Quantum computational chemistry has emerged as a potential application of quantum computing. Hybrid quantum-classical computing methods, such as variational quantum eigensolvers, have been designed as promisin...
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Article
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol
Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating e...
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Article
Open AccessIdentification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6
Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological tumors. However, its immune-related carcinogenic mechanism in other tumors remains unc...
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Article
Direct ink writing of multifunctional gratings with gel-like MXene/norepinephrine ink for dynamic electromagnetic interference shielding and patterned Joule heating
Intelligent electromagnetic interference (EMI) shielding modulators with a wide tuning range and cyclic stability are urgently needed but their fabrication remains challenging. A gel-like MXene/norepinephrine ...
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Article
Open AccessVirome diversity shaped by genetic evolution and ecological landscape of Haemaphysalis longicornis
Haemaphysalis longicornis is drawing attentions for its geographic invasion, extending population, and emerging disease threat. However, there are still substantial gaps in our knowledge of viral composition in r...
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Article
Open AccessCamrelizumab and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma: a phase 2 clinical trial
The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Patients with N3 nasopharyngeal carcinoma have a high risk of distant m...
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Article
Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity
To investigate the effects of Pien Tze Huang (PZH) on the migration and invasion of HCC cells and underlying molecular mechanism.
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Article
Clinical risk factors and prognostic model for patients with bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation
Bronchiolitis obliterans syndrome (BOS) is a common and potentially devastating noninfectious pulmonary complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Currently, predictive ...
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Article
Open AccessSurplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy
Adipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear. Here, we show that surplus fatty a...
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Article
Effect of solid solution treatment on microstructure and properties of extruded 7055 aluminum alloy
The effect of solid solution parameter and quenching cooling rate on the microstructure and properties of the 7055 aluminum alloy was studied by scanning electron microscopy (SEM), transmission electron micros...
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Article
Radiomics nomogram for the prediction of microvascular invasion of HCC and patients’ benefit from postoperative adjuvant TACE: a multi-center study
To evaluate the performance of a radiomics nomogram developed based on gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) MRI for preoperative prediction of microvascular invasion (MVI)...
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Article
Seepage characteristics test of carbonaceous mudstone soil-rock mixture considering rock content and rainfall infiltration angle
To investigate the infiltration characteristics of carbonaceous mudstone soil-rock mixtures under the effect of rainfall infiltration, model tests considering rock contents and rainfall infiltration angles wer...
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Article
Open AccessEffects of early mental state changes on physical functions in elderly patients with a history of falls
Fear of falling is a potential consequence for older adults who have experienced a fall. Whether such psychological concerns related to falls, in turn, affect physical function? Especially those who have a his...
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Article
Open AccessInter-bacterial mutualism promoted by public goods in a system characterized by deterministic temperature variation
Mutualism is commonly observed in nature but not often reported for bacterial communities. Although abiotic stress is thought to promote microbial mutualism, there is a paucity of research in this area. Here, ...
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Article
Ambient PM2.5-bound polycyclic aromatic hydrocarbons in Ningbo Harbor, eastern China: seasonal variation, source apportionment, and cancer risk assessment
Field measurements were conducted at a container harbor located in Ningbo-Zhoushan Port, China. Concentrations of fifty-three PAHs in airborne PM2.5 were quantified using gas chromatography-mass spectrometry (GC-...
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Article
Generation of genuine entanglement up to 51 superconducting qubits
Scalable generation of genuine multipartite entanglement with an increasing number of qubits is important for both fundamental interest and practical use in quantum-information technologies1,2. On the one hand, m...
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Article
Microstructure and mechanical properties of Ti43Al6Nb alloys with different zirconium contents
Ti43Al6Nb-xZr alloys with different additions of zirconium were prepared by vacuum arc melting furnace. The microstructure and compressive properties at room temperature (RT) were investigated. The microstructure...
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Article
Open AccessHalide Perovskite glues activate two-dimensional covalent organic framework crystallites for selective NO2 sensing
Two-dimensional covalent organic frameworks (2D COFs) are promising for gas sensing owing to the large surface area, abundant active sites, and their semiconducting nature. However, 2D COFs are usually produce...
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Article
Epitranscriptomic profiling of m6A RNA methylation in renal epithelial tubular cells stimulated with calcium oxalate crystals through microarray analysis
The aim of this study was to investigate the relationship of m6A RNA methylation to CaOX-induced renal tubular injury. Microarray analysis was performed to detect the difference in mRNA expression and m6A meth...
