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Article
Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection
Emerging evidence suggests that neurological and other post-acute sequelae of COVID-19 can persist beyond or develop following SARS-CoV-2 infection. However, the long-term trajectories of cognitive change afte...
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Article
Open AccessGenome-wide analysis and expression profiling of the HD-ZIP gene family in kiwifruit
The homeodomain-leucine zipper (HD-Zip) gene family plays a pivotal role in plant development and stress responses. Nevertheless, a comprehensive characterization of the HD-Zip gene family in kiwifruit has bee...
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Article
Progress of 3-ketosteroid Δ1-dehydrogenases for steroid production
3-ketosteroid Δ1-dehydrogenases (Δ1-KstDs) are FAD-dependent and substrate-inducing enzymes, which catalyze the introduction of double bonds between C1 and C2 atoms of the A ring of 3-ketosteroid substrates. They...
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Article
Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Article
Open AccessIP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway
Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca2+) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...
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Article
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain ...
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Article
Preliminary Investigation on Efficacy and Safety of Substance P-Coated Stent for Promoting Re-Endothelialization: A Porcine Coronary Artery Restenosis Model
Current polymer-based drug-eluting stents (DESs) have fundamental issues about inflammation and delayed re-endothelializaton of the vessel wall. Substance-P (SP), which plays an important role in inflammation ...
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Article
Flat-leaf submerged plants are more sensitive to invasion intensity and water nutrition levels than needle-leaf ones
Plant invasion and water eutrophication severely damage wetland plant growth. However, the effects of plant invasion and water nutrient levels on the growth of submerged plants with different leaf types remain...
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Article
Fulvivirga sedimenti sp.nov, isolated from the sediment of oceanic tidal zone
A yellow-orange, rod-shaped (0.3–0.4 × 2.2–3.8 µm), Gram-stain-negative, non-motile, atrichous bacterium, designated strain 1062T, was isolated from tidal zone sediment collected from **aoshi Island, Weihai, Shan...
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Article
Open AccessDNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis
Previously, we reported the expression of DLX4 isoforms (BP1 and DLX7) in myeloid leukemia, but the functional role of DLX4 isoforms remains poorly understood. In the work described herein, we further determined ...
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Article
Open AccessCircUBE2Q2 promotes differentiation of cattle muscle stem cells and is a potential regulatory molecule of skeletal muscle development
The growth and development of muscle stem cells (MuSCs) are significant events known to affect muscle plasticity, disease, meat production, and meat quality, which involves the types and functions of mRNA and ...
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Article
Flavonoid components and gene expression analysis reveal flower pigmentation difference between Magnolia biondii and its variety M. biondii var. purpurascens
Compared with Magnolia biondii , higher anthocyanin content and higher expression level of related structural genes involved in flavonoids biosynthesis were...
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Article
A robust mechanism for resetting juvenility during each generation in Arabidopsis
Multicellular organisms undergo several developmental transitions during their life cycles. In contrast to animals, the plant germline is derived from adult somatic cells. As such, the juvenility of a plant mu...
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Article
Open AccessRole of cassava CC-type glutaredoxin MeGRXC3 in regulating sensitivity to mannitol-induced osmotic stress dependent on its nuclear activity
We previously identified six drought-inducible CC-type glutaredoxins in cassava cultivars, however, less is known about their potential role in the molecular mechanism by which cassava adapted to abiotic stress.
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Article
Effects of Mn2+ on neutral lipid content, C4 pathway, and related gene expression in Phaeodactylum tricornutum
The neutral lipids from the diatom Phaeodactylum tricornutum are a valuable substance with a vital role in biofuel. Increasing the neutral lipid content of P. tricornutum through nutritional stress, such as nitro...
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Article
Open AccessFibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4
Cancer-associated fibroblasts (CAFs) play an essential role in supporting cancer progression. However, the details and consequent effects in response to the communication between CAFs and angiogenesis remain l...
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Article
Open AccessHistone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1
TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still r...
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Article
Biotransformation of Phlorizin by Eurotium cristatum to Increase the Antioxidant and Antibacterial Activity of Docynia indica Leaves
Docynia indica is used as a plant resource for both medicine and food in minority areas of southwestern China and Southeast of Asia, especially Docynia indica leaves, which are often used as a kind of functional ...
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Article
At3g53630 encodes a GUN1-interacting protein under norflurazon treatment
Chloroplasts are semi-autonomous organelles, with more than 95% of their proteins encoded by the nuclear genome. The chloroplast-to-nucleus retrograde signals are critical for the nucleus to coordinate its gen...
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Article
Preliminary report on the improved resistance towards Pseudomonas syringae pv. actinidiae of cultivated kiwifruit (Actinidia chinensis) when grafted onto wild Actinidia guilinensis rootstock in vitro
The production of kiwifruit around the world is widely affected by the bacterial canker disease caused by Pseudomonas syringae pv. actinidiae (Psa). The use of resistant rootstock is considered to be an effective...