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Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma

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  1. Article

    Open Access

    HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis

    The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...

    Ya-juan Guo, **g-**g Yao, Zhen-zhen Guo, Ming Ding… in Acta Pharmacologica Sinica (2024)

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  2. Article

    Identification of SARS-CoV-2 entry inhibitors among already approved drugs

    To discover effective drugs for COVID-19 treatment amongst already clinically approved drugs, we developed a high throughput screening assay for SARS-CoV-2 virus entry inhibitors using SARS2-S pseudotyped viru...

    Li Yang, Rong-juan Pei, Heng Li, **n-na Ma, Yu Zhou… in Acta Pharmacologica Sinica (2021)

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  3. Article

    Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer

    Pim-2 is a short-lived serine/threonine kinase, which plays a key role in metastasis of breast cancer through persistent activation of STAT3. Although the crystal structure of Pim-2 has been reported, but thus...

    Yu-qian Zhao, Yi-qiong Yin, Jie Liu, Gui-hua Wang, Jian Huang… in Acta Pharmacologica Sinica (2016)

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  4. Article

    Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells

    The pentose phosphate pathway (PPP) is involved in the activity of glucose-6-phosphate dehydrogenase (G6PD) and generation of NADPH, which plays a key role in drug metabolism. The aim of this study was to inve...

    Wen-**g **ao, Ting Ma, Chun Ge, Wen-juan **a, Yong Mao… in Acta Pharmacologica Sinica (2015)

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  5. Article

    Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo

    20(S)-Ginsenoside Rh2 (Rh2) has shown potent inhibition on P-glycoprotein (P-gp), while most HIV protease inhibitors are both substrates and inhibitors of P-gp and CYP3A4. The aim of this study was to investigate...

    Jian Shi, Bei Cao, Wei-bin Zha, **ao-lan Wu, Lin-sheng Liu… in Acta Pharmacologica Sinica (2013)

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  6. Article

    Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5

    The mitotic kinesin Eg5 plays a critical role in bipolar spindle assembly, and its inhibitors have shown impressive anticancer activity in preclinical studies. This study was undertaken to investigate the effe...

    **ao-dong Sun, **ng-juan Shi, **ao-ou Sun, You-guang Luo… in Acta Pharmacologica Sinica (2011)

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  7. Article

    The proteomic analysis of human neonatal umbilical cord serum by mass spectrometry

    To investigate the proteome composition and function of human neonatal arterial umbilical cord.

    Hong-juan Song, ** Zhang, Xue-jiang Guo, Lian-ming Liao… in Acta Pharmacologica Sinica (2009)

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