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Article
Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection
Emerging evidence suggests that neurological and other post-acute sequelae of COVID-19 can persist beyond or develop following SARS-CoV-2 infection. However, the long-term trajectories of cognitive change afte...
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Article
Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma
Metabolic changes play a crucial role in determining the status and function of macrophages, but how lipid reprogramming in macrophages contributes to tumor progression is not yet fully understood. Here, we in...
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Article
Open AccessHBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis
The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...
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Article
Open AccessThe 90% effective concentration of alfentanil combined with 0.075% ropivacaine for epidural labor analgesia: a single-center, prospective, double-blind sequential allocation biased-coin design
More literature studies have reported that alfentanil is safe and effective for labor analgesia. However, there is no unified consensus on the optimal dosage of alfentanil used for epidural analgesia. This stu...
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Article
New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignancy, presenting a formidable challenge to the medical community owing to its intricate pathogenic mechanisms. Although current prevention, survei...
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Article
Research progress of permanent ferrite magnet materials
Permanent ferrite magnet materials are extensively employed due to their exceptional magnetic properties and cost-effectiveness. The fast development in electromobile and household appliance industries contrib...
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Article
Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention
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Article
Open AccessGenome-wide analysis and expression profiling of the HD-ZIP gene family in kiwifruit
The homeodomain-leucine zipper (HD-Zip) gene family plays a pivotal role in plant development and stress responses. Nevertheless, a comprehensive characterization of the HD-Zip gene family in kiwifruit has bee...
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Article
Phosphorus additives driving the bacterial community succession during Bacillus spp. remediation of the uranium tailings
Uranium tailings discharged into uranium tailings ponds could generate environmental pollution issues. Microbial-induced phosphate mineralization could reduce the release of uranium, in turn effectively managi...
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Article
Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis
As a vital component of the hepatitis B virus (HBV) nucleocapsid, HBV core protein (HBC) contributes to hepatocarcinogenesis. Here, we aimed to assess the effects of RANGAP1 and KDM2A on tumorigenesis induced ...
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Article
Progress of 3-ketosteroid Δ1-dehydrogenases for steroid production
3-ketosteroid Δ1-dehydrogenases (Δ1-KstDs) are FAD-dependent and substrate-inducing enzymes, which catalyze the introduction of double bonds between C1 and C2 atoms of the A ring of 3-ketosteroid substrates. They...
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Article
Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Article
Open AccessQuality appraisal and descriptive analysis of clinical practice guidelines for self-managed non-pharmacological interventions of cardiovascular diseases: a systematic review
Cardiovascular diseases (CVDs) are the leading cause of death around the world. Most CVDs-related death can be prevented by the optimal management of risk factors such as unhealthy diet and physical inactivity...
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Article
Effect of heavy-do** Eu3+ and charge compensation on crystalline phase and luminescence properties of K2CaP2O7 phosphors emitting orange-red light
A series of K2Ca1-xP2O7:xEu3+ phosphors were prepared by a high-temperature solid-state reaction method. The crystal structure was analyzed by X-ray diffraction (XRD). Fluorescence spectra, decay curves, and colo...
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Article
Open AccessIP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway
Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca2+) has been associated with cardiomyocyte pyroptosis. Specifically, the inositol 1,4,5-trisphosphate receptor type 2 (IP...
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Article
Open AccessAssociation of antenatal corticosteroids with mortality and morbidities in very preterm infants born to women with hypertensive disorders of pregnancy: a multicenter prospective cohort study
Hypertensive disorders of pregnancy (HDP) is the most common cause of indicated preterm delivery, but the impact of prenatal steroid exposure on the outcomes of preterm infants born to HDP mothers, who may be ...
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Article
Aerobic Glycolysis Induced by mTOR/HIF-1α Promotes Early Brain Injury After Subarachnoid Hemorrhage via Activating M1 Microglia
M1 microglial activation is crucial for the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH), and there is growing evidence that glucose metabolism is frequently involved in mic...
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Article
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain ...
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Chapter and Conference Paper
Fracturing Model Experiment of Fengxi Tight Oil Reservoir
In view of the morphology of pressure fracture network in Qaidam high stress carbonate reservoir, a small size true triaxial hydraulic fracturing system was used to carry out full-diameter downhole core fractu...
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Chapter and Conference Paper
Research on Parameter Optimization of Temporary Plugging Agent for Fracturing
Focusing on the matching of temporary plugging agent and hydraulic fracture width, a multi-scale optimal design method of temporary plugging agent was established to control the permeability and strength of pl...
