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Article
Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers
Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at antigen presentation. Here we report the design and performance of a DC-targeting virus-like particle pseudotyped w...
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Article
Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Article
Breeding of Saccharomyces cerevisiae with a High-Throughput Screening Strategy for Improvement of S-Adenosyl-L-Methionine Production
S-adenosyl-l-methionine (SAM), a vital physiologically active substance in living organisms, is produced by fermentation over Saccharomyces cerevisiae. The main limitation in SAM production was the low biosynthes...
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Article
Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity
Malignant obstruction makes gallbladder cancer have a high mortality rate. Nickel–titanium alloy (nitinol) stents are commonly used as a local intervention to maximize patient survival time, but the stents lac...
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Article
Promising single-atom catalysts for lithium-sulfur batteries screened by theoretical density functional theory calculations
Exploring prominent active centers with high catalytic activity is essential for develo** single-atom catalysts (SACs) towards lithium-sulfur batteries (LSBs). Based on density functional theory calculations...
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Article
Degradation of Rhodamine B by MnFe-LDH/PMS/O3 three-phase catalytic system: performance, mechanism and ecotoxicity studies
This study developed a novel MnFe-LDH/PMS/O3 three-phase catalytic system to degrade the organic dye RhB, which was used to address the drawbacks of persulfate oxidation and ozonation techniques. The structure, i...
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Article
Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions
Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although man...
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Article
A molecular sieve-containing protective separator to suppress the shuttle effect of redox mediators in lithium-oxygen batteries
Lithium-oxygen (Li-O2) batteries have a great potential in energy storage and conversion due to their ultra-high theoretical specific energy, but their applications are hindered by sluggish redox reaction kinetic...
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Article
Open AccessEvolution of surface area and membrane shear modulus of matured human red blood cells during mechanical fatigue
Mechanical properties of red blood cells (RBCs) change during their senescence which supports numerous physiological or pathological processes in circulatory systems by providing crucial cellular mechanical en...
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Article
Rational design of robust iridium-ceria oxide-carbon nanofibers to boost oxygen evolution reaction in both alkaline and acidic media
Anodic oxygen evolution reaction (OER) is essential to participate in diverse renewable energy conversion and storage processes, while most OER electrocatalysts present satisfactory catalytic performance in on...
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Article
Open AccessAttacking neural machine translations via hybrid attention learning
Deep-learning based natural language processing (NLP) models are proven vulnerable to adversarial attacks. However, there is currently insufficient research that studies attacks to neural machine translations ...
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Article
Open AccessCloning southern corn rust resistant gene RppK and its cognate gene AvrRppK from Puccinia polysora
Broad-spectrum resistance has great values for crop breeding. However, its mechanisms are largely unknown. Here, we report the cloning of a maize NLR gene, RppK, for resistance against southern corn rust (SCR) an...
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Article
Lymph node ratio-based the ypTNrM staging system for gastric cancer after neoadjuvant therapy: a large population-based study
The lymph node ratio (LNR) has been considered a better prognostic factor than traditional N staging in patients with gastric cancer (GC), but its accuracy is unclear for those who receive neoadjuvant therapy ...
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Article
Open AccessActivation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2–selective inhibitor venetoclax (VEN) alone or in combinations commonly acquires resistance. We performed gene/protein ex...
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Article
Critical adhesion areas of cells on micro-nanopatterns
Cell adhesion to extracellular matrices (ECM) is critical to physiological and pathological processes as well as biomedical and biotechnological applications. It has been known that a cell can adhere on an adh...
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Article
Phospholipid Compositions in Portunus trituberculatus Larvae at Different Developmental Stages
Phospholipids are used to improve the growth and survival of Portunus trituberculatus, a widely cultured crab species in China. However, only total phospholipids or several classes are applied in crab diets. In t...
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Article
Open AccessVAV2 is required for DNA repair and implicated in cancer radiotherapy resistance
Radiotherapy remains the mainstay for treatment of various types of human cancer; however, the clinical efficacy is often limited by radioresistance, in which the underlying mechanism is largely unknown. Here,...
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Article
Open AccessSystematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy
One of the best ways to control COVID-19 is vaccination. Among the various SARS-CoV-2 vaccines, inactivated virus vaccines have been widely applied in China and many other countries. To understand the underlyi...
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Article
Open AccessWolfberry genomes and the evolution of Lycium (Solanaceae)
Wolfberry Lycium, an economically important genus of the Solanaceae family, contains approximately 80 species and shows a fragmented distribution pattern among the Northern and Southern Hemispheres. Although seve...
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Article
Systematic profiling of SARS-CoV-2-specific IgG epitopes at amino acid resolution
