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Article
Isolation and identification of genes expressed differentially in rice inflorescence meristem with suppression subtractive hybridization
A subtracted cDNA library of rice (Oryza sativa L.) inflorescence meristem (EM) was constructed using the suppression subtractive hybridization (SSII) method. The cDNAs of the rice shoot apical meristem (SAM) wer...
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Article
Sulfoalkyl ether β-cyclodextrin derivatives synthesized by a single step method as pharmaceutical biomaterials
We report a simple “one pot” single step method to synthesize sulfoalkyl ether β-cyclodextrin (β-CD) derivatives in aqueous solution, which avoids the limitations associated with commonly used organic synthesi...
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Article
Open AccessOptimization of protein production by Micrococcus luteus for exploring pollutant-degrading uncultured bacteria
The screening of pollutant-degrading bacteria are limited due to most of bacteria in the natural environment cannot be cultivated. For the purpose of resuscitating and stimulating “viable but non-culturable” (...
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Article
Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development
Here, the helix–loop–helix transcription factor Ascl2 is shown to be critically important for the initiation of follicular T-helper-cell development and the germinal centre response.
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Article
Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides
Genetic correction of MeCP2 levels largely reversed the behavioural, molecular and physiological deficits associated with MECP2 duplication syndrome in a transgenic mouse model; similarly, reduction of MeCP2 leve...
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Article
Open AccessIntermediate honeycomb ordering to trigger oxygen redox chemistry in layered battery electrode
Sodium-ion batteries are attractive energy storage media owing to the abundance of sodium, but the low capacities of available cathode materials make them impractical. Sodium-excess metal oxides Na2MO3 (M: transi...
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Article
Open AccessPioneering In Situ Recrystallization during Bead Milling: A Top-down Approach to Prepare Zeolite A Nanocrystals
Top-down approach has been viewed as an efficient and straightforward method to prepare nanosized zeolites. Yet, the mechanical breaking of zeolite causes amorphization, which usually requires a post-milling r...
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Article
Open AccessNotch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
Functional blood vessel growth depends on generation of distinct but coordinated responses from endothelial cells. Bone morphogenetic proteins (BMP), part of the TGFβ superfamily, bind receptors to induce phos...
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Article
Open AccessEvolution of the intrinsic electronic phase separation in La0.6Er0.1Sr0.3MnO3 perovskite
Magnetic and electronic transport properties of perovskite manganite La0.6Er0.1Sr0.3MnO3 have been thoroughly examined through the measurements of magnetization, electron paramagnetic resonance(EPR), and resistiv...
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Article
Open AccessEmpty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly
This study evaluated the association between empty-nest-related psychological distress and the progression of white matter lesions (WMLs) and cognitive impairment in 219 elderly subjects aged 60 years or over....
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Article
Open AccessSystematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector
Cloning of multiple genes in a single vector has greatly facilitated both basic and translational studies that require co-expression of multiple factors or multi-units of complex protein. Many strategies have ...
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Article
Open AccessIncreased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010–2015
Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne viral disease with high mortality. Since January 2010, we have conducted an epidemiological surveillance and etiological study of SFTS i...
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Article
Open AccessFreeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separation surgery
Preoperative assessment of tissue anatomy and accurate surgical planning is crucial in conjoined twin separation surgery. We developed a new method that combines three-dimensional (3D) printing, assembling, an...
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Article
Open AccessInhibitory effect and mechanism of Tagetes erecta L. fungicide on Fusarium oxysporum f. sp. niveum
Botanical fungicides comprise attractive alternatives to chemical fungicides because of their environmental compatibility. Flavonoids extracted from Tagetes erecta L. have an inhibitory effect on fusarium wilt in...
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Article
Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte
Single-cell transcriptomics analyses of cell intermediates during the reprogramming from fibroblast to cardiomyocyte were used to reconstruct the reprogramming trajectory and to uncover intermediate cell popul...
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Article
Open AccessNotch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification
Hey2 gene mutations in both humans and mice have been associated with multiple cardiac defects. However, the currently reported localization of Hey2 in the ventricular compact zone cannot explain the wide variety...
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Article
Open AccessRapamycin attenuates pathological hypertrophy caused by an absence of trabecular formation
Cardiac trabeculae are mesh-like muscular structures within ventricular walls. Subtle perturbations in trabeculation are associated with many congenital heart diseases (CHDs), and complete failure to form trab...
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Article
Open AccessRole of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV
The association between mucosal microbiota and HIV-1 infection has garnered great attention in the field of HIV-1 research. Previously, we reported a receptor-independent HIV-1 entry into epithelial cells medi...
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Article
Open AccessApparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
Recent studies have suggested that genes longer than 100 kb are more likely to be misregulated in neurological diseases associated with synaptic dysfunction, such as autism and Rett syndrome. These length-depe...
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Article
Open AccessLongitudinal association of carotid endothelial shear stress with renal function decline in aging adults with normal renal function: A population-based cohort study
The aim of this study was to investigate the associations between carotid wall shear stress (WSS) and renal function impairment (RFI) and albuminuria in aging adults. A total of 1,447 subjects aged 60 years an...