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Article
Synthesis of Chlorfenazole from 2-Chlorobenzalmalononitrile Extracted from Expired Tear-Gas Grenade
Tear gases were originally manufactured as weapons that could severely disable or kill enemy troops. Though banned in war, these chemicals are still used in domestic policing. Due to ammunition management rule...
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Article
Temperate Stutzerimonas Phage Encoding Toxin-Antitoxin System Genes Represents a Novel Genus
Stutzerimonas have been extensively studied due to their remarkable metabolic and physiological diversity. However, research on its phages is currently limited. In this study, we isolated a novel double-stranded ...
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Article
High hyperdiploid karyotype with ≥ 49 chromosomes represents a heterogeneous subgroup of acute myeloid leukemia with differential TP53 mutation status and prognosis: a single-center study from China
High hyperdiploid karyotype with ≥ 49 chromosomes (which will be referred to as HHK) is rare in acute myeloid leukemia (AML). The European leukemia network (ELN) excluded those harboring only numerical changes...
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Article
The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells
Cancer stem cells (CSCs) play an important role in metastasis development, tumor recurrence, and treatment resistance, and are essential for the eradication of cancer. Currently, therapies fail to eradicate CS...
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Article
A real-time PCB defect detection model based on enhanced semantic information fusion
Aiming at the problem of poor balance between real-time and performance of existing PCB board defect detection algorithms, this paper proposes a fast PCB board detection model based on enhanced semantic inform...
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Article
Open AccessRandomized trial comparing the effects of a 3D head-up system and microscope eyepiece-assisted simulated vitrectomy with intraocular illumination on the ocular surface of an operator
To compare the effects of a 3D head-up system and microscope eyepiece-assisted simulated vitrectomy intraocular illumination on the ocular surface of an operator.
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Article
Open AccessAssociations of life’s essential 8 with extent of multi-territorial atherosclerotic plaques and stenosis: a cross-sectional study
Life’s Essential 8 (LE8), the recently updated construct for quantifying cardiovascular health, is related to the risks of cardiovascular events. The present study aimed to evaluate associations of LE8 score w...
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Article
Open AccessIs neoadjuvant chemotherapy necessary for T2N0-1M0 hormone receptor-positive/HER2-negative breast cancer patients undergoing breast-conserving surgery?
For HR-positive/HER2-negative patients who can undergo breast-conserving surgery (BCS) but have a tumor size of 2–5 cm or 1–3 lymph node metastases, neoadjuvant chemotherapy (NAC) is still controversial.
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Article
Open AccessTocilizumab is associated with reduced delirium and coma in critically ill patients with COVID-19
Recent preclinical studies demonstrate a direct pathological role for the interleukin-6 (IL-6) pathway in mediating structural and functional delirium-like phenotypes in animal models of acute lung injury. Toc...
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Article
Open AccessPredictive Partly Conditional Models for Longitudinal Ordinal Outcomes with Application to Alzheimer’s Disease Progression
Assessing time-dependent risk factors in relation to the risk of disease progression is challenging, yet important, especially for chronic diseases with slow progression. In this paper, the partly conditional ...
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Article
Open AccessMorphological and molecular characterization of Eimeria haematopusi n. sp. (Apicomplexa: Eimeriidae) in an Australian Pied Oystercatcher (Haematopus longirostris) (Aves: Charadriiformes)
A novel Eimeria Schneider, 1875 species is described from an Australian pied oystercatcher Haematopus longirostris Vieillot, in Western Australia. The pied oystercatcher was admitted to the Kanyana Wildlife Rehab...
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Article
Simultaneous use of two-step fermentation and in-situ addition of chitosan oligosaccharide improving bacterial cellulose pellicle in the synthesis and various behaviors
Low productivity, high cost, and imbalance between swelling behavior and mechanical properties have limited extensive applications of bacterial cellulose pellicles (BCPs). To remove the drawbacks, two-step fer...
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Article
Open AccessPhosphoproteomic analysis reveals changes in A-Raf-related protein phosphorylation in response to Toxoplasma gondii infection in porcine macrophages
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes severe threats to humans and livestock. Macrophages are the cell type preferentially infected by T. gondii in vivo. Protein phosphoryl...
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Article
Open AccessPre-rotation Only at Inference-Stage: A Way to Rotation Invariance of Convolutional Neural Networks
The popular convolutional neural networks (CNN) require data augmentation to achieve rotation invariance. We propose an alternative mechanism, Pre-Rotation Only at Inference stage (PROAI), to make CNN rotation...
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Article
Can neoadjuvant systemic therapy provide additional benefits for T1 HER2+ breast cancer patients: a subgroup analysis based on different high-risk signatures
Neoadjuvant systemic therapy (NAST) is vital in the management of HER2-positive (HER2+) breast cancer. Nevertheless, the indications for NAST in tumors <2 cm remain controversial.
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Article
Industrial fluoride emissions and their spatial characteristics in the Nansi Lake Basin, Eastern China
Excessive fluoride emissions threaten ecological stability and human health. Previous studies have noted that industrial sources could be significant. However, quantifying industrial fluoride emissions has not...
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Article
Recurrence and Complications of Peri-operative Steroid Injection of Keloids: A Systematic Review and Meta-analysis
Keloid scars are a particularly challenging fibroproliferative wound healing disorder with a variety of proposed management approaches including concurrent surgery and intralesional steroid injection. We aimed...
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Article
Image retrieval based on dimensionality reduction of second-order information
Identifying similar images within databases is a significant challenge in the field of image retrieval. This challenge is further compounded by escalating demands for heightened precision and speed, propelled ...
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Article
Open AccessWnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration
Neovascular age-related macular degeneration (nAMD), accounts for up to 90% of AMD-associated vision loss, ultimately resulting in the formation of fibrotic scar in the macular region. The pathogenesis of subr...
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Article
Highly efficient photoelectrochemical aptasensor based on CdS/CdTe QDs co-sensitized TiO2 nanoparticles designed for thrombin detection
A photoelectrochemical (PEC) sensor for the sensitive detection of thrombin (TB) was established. Co-sensitized combination of TiO2 nanoparticles combined with modified cadmium sulfide and cadmium telluride quant...
