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Article
Open AccessRegulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment
Several studies have demonstrated the role of the oncogenic mutant p53 in promoting tumor progression; however, there is limited information on the effects of secreted oncogenic mutant p53 on the tumor microen...
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Chapter and Conference Paper
Electromagnetic Design and Analysis of 1.2 MW Direct-Drive Permanent Magnet Synchronous Motor
Direct-drive permanent magnet synchronous motor (DDPMSM) technology is a key research issue in the field of future rail transport. In this paper, the key electromagnetic design problems of DDPMSM for electric ...
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Article
A quantitative assessment of (bacterio)chlorophyll assignments in the cryo-EM structure of the Chloracidobacterium thermophilum reaction center
Chlorophylls and bacteriochlorophylls are the primary pigments used by photosynthetic organisms for light harvesting, energy transfer, and electron transfer. Many molecular structures of (bacterio)chlorophyll-...
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Article
Tools for analyzing protonation states and for tracing proton transfer pathways with examples from the Rb. sphaeroides photosynthetic reaction centers
Protons participate in many reactions. In proteins, protons need paths to move in and out of buried active sites. The vectorial movement of protons coupled to electron transfer reactions establishes the transm...
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Article
Glycerol binding at the narrow channel of photosystem II stabilizes the low-spin S2 state of the oxygen-evolving complex
The oxygen-evolving complex (OEC) of photosystem II (PSII) cycles through redox intermediate states Si (i = 0–4) during the photochemical oxidation of water. The S2 state involves an equilibrium of two isomers in...
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Article
A review of the botany, traditional uses, phytochemistry and pharmacology of Nepeta tenuifolia Briq.
Nepeta tenuifolia (N. tenuifolia) is a common aromatic herb that is widespread in East Asia. The aerial parts and spikes can be used as the traditional phytomedicines for the treatment of cold, fever, respiratory...
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Article
Open AccessMulti-omics analysis of the bioactive constituents biosynthesis of glandular trichome in Perilla frutescens
Perilla frutescens (L.) Britt is a medicinal and edible plant widely cultivated in Asia. Terpenoids, flavonoids and phenolic acids are the primary source of medicinal ingredients. Glandular trichomes with multice...
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Protocol
Preparing Membrane Proteins for Simulation Using CHARMM-GUI
Molecular dynamics simulations of membrane proteins have grown dramatically in the last 20 years. Running these simulations first requires embedding the protein’s three-dimensional structure in a lipid bilayer...
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Article
Gingipain of Porphyromonas gingivalis manipulates M1 macrophage polarization through C5a pathway
Gingipains secreted by Porphyromonas gingivalis (P. gingivalis, Pg) play an important role in maintaining macrophage infiltrating. And, this study is to evaluate effects of gingipain on M1 macrophage polarization...
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Article
The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson’s Disease in Rats
The etiology and pathogenesis of Parkinson’s disease (PD) are complicated and have not been fully elucidated, but an important association has been identified between inflammation and PD. In this study, we inv...
