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  1. Article

    Open Access

    Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

    Early insulin therapy is capable to achieve glycemic control and restore β-cell function in newly diagnosed type 2 diabetes (T2D), but its effect on cardiovascular outcomes in these patients remains unclear. I...

    Sihui Luo, Xueying Zheng, Wei Bao, Sheng Nie… in Signal Transduction and Targeted Therapy (2024)

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  2. Article

    Open Access

    A novel strategy sequentially linking mechanical cardiopulmonary resuscitation with extracorporeal cardiopulmonary resuscitation optimizes prognosis of refractory cardiac arrest: an illustrative case series

    Extracorporeal membrane oxygenation (ECMO) to support cardiopulmonary resuscitation (CPR), also known as extracorporeal cardiopulmonary resuscitation (ECPR), has shown encouraging results in refractory cardiac...

    Linhui Hu, Kaiyi Peng, **angwei Huang, Zheng Wang… in European Journal of Medical Research (2022)

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  3. No Access

    Article

    Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling

    Histone demethylase JMJD2D can promote gene expression by specifically demethylating H3K9me2/3. The role of JMJD2D in colitis and colitis-associated colorectal cancer (CRC) progression remains unclear. Here, w...

    Minghui Zhuo, Wenbo Chen, Shaohui Shang, Peng Guo, Kesong Peng, Ming Li… in Oncogene (2020)

  4. No Access

    Article

    Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gαi protein/MAPK/MMP9 intracellular signaling

    While androgens may function via nuclear androgen receptor (nAR) to increase bladder cancer (BCa) progression, the impact of androgens on muscle invasive BCa, which contains nearly 80% nAR-negative cells, rema...

    **bo Chen, Fuju Chou, Shuyuan Yeh, Zhenyu Ou, Chihrong Shyr, Chi** Huang… in Oncogene (2020)

  5. No Access

    Article

    The dysfunction of BP180/collagen XVII in keratinocytes promotes melanoma progression

    BP180, also termed collagen XVII, is a hemidesmosomal transmembrane glycoprotein expressed in basal keratinocytes, and functions as a cell–matrix adhesion molecule in the dermal–epidermal junction of the skin....

    Bin-** Hwang, Yang Zhang, Jaime M. Brozowski, Zhen Liu, Susan Burette… in Oncogene (2019)

  6. No Access

    Article

    Maternal adipokines longitudinally measured across pregnancy and their associations with neonatal size, length, and adiposity

    Maternal obesity impacts fetal growth as early as second trimester of pregnancy, yet little is known about the molecular mechanisms involved. We aimed to examine associations between maternal adipokines throug...

    Stefanie N. Hinkle, Shristi Rawal, Dan** Liu… in International Journal of Obesity (2019)