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  1. No Access

    Article

    Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling

    Histone demethylase JMJD2D can promote gene expression by specifically demethylating H3K9me2/3. The role of JMJD2D in colitis and colitis-associated colorectal cancer (CRC) progression remains unclear. Here, w...

    Minghui Zhuo, Wenbo Chen, Shaohui Shang, Peng Guo, Kesong Peng, Ming Li… in Oncogene (2020)

  2. No Access

    Article

    Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gαi protein/MAPK/MMP9 intracellular signaling

    While androgens may function via nuclear androgen receptor (nAR) to increase bladder cancer (BCa) progression, the impact of androgens on muscle invasive BCa, which contains nearly 80% nAR-negative cells, rema...

    **bo Chen, Fuju Chou, Shuyuan Yeh, Zhenyu Ou, Chihrong Shyr, Chi** Huang… in Oncogene (2020)

  3. No Access

    Article

    The dysfunction of BP180/collagen XVII in keratinocytes promotes melanoma progression

    BP180, also termed collagen XVII, is a hemidesmosomal transmembrane glycoprotein expressed in basal keratinocytes, and functions as a cell–matrix adhesion molecule in the dermal–epidermal junction of the skin....

    Bin-** Hwang, Yang Zhang, Jaime M. Brozowski, Zhen Liu, Susan Burette… in Oncogene (2019)