16 Result(s)

Article

Development and validation of a novel immune-related prognostic signature in lung squamous cell carcinoma patients

Lung Squamous Cell Carcinoma (LUSC) is an aggressive malignancy with limited therapeutic options. The response to immune therapy is a determining factor for the prognosis of LUSC patients. This study aimed to ...

**anyu Liu, Deze Zhao, Yunhan Shan, Weifang Cui, Qun **e… in Scientific Reports (2022)

Article

Genomic basis of the giga-chromosomes and giga-genome of tree peony Paeonia ostii

Tree peony (Paeonia ostii) is an economically important ornamental plant native to China. It is also notable for its seed oil, which is abundant in unsaturated fatty acids such as α-linolenic acid (ALA). Here, we...

Junhui Yuan, Sanjie Jiang, Jianbo Jian, Mingyu Liu, Zhen Yue… in Nature Communications (2022)

Article

Digital quantum simulation of Floquet symmetry-protected topological phases

Quantum many-body systems away from equilibrium host a rich variety of exotic phenomena that are forbidden by equilibrium thermodynamics. A prominent example is that of discrete time crystals^1–8, in which time-tr...

Xu Zhang, Wenjie Jiang, **feng Deng, Ke Wang, Jiachen Chen, Pengfei Zhang… in Nature (2022)

Article

Modulating Pt-O-Pt atomic clusters with isolated cobalt atoms for enhanced hydrogen evolution catalysis

Platinum is the most efficient catalyst for hydrogen evolution reaction in acidic conditions, but its widespread use has been impeded by scarcity and high cost. Herein, Pt atomic clusters (Pt ACs) containing P...

Yufei Zhao, Priyank V. Kumar, **n Tan, **nxin Lu, **aofeng Zhu… in Nature Communications (2022)

Article

Author Correction: A graph placement methodology for fast chip design

Azalia Mirhoseini, Anna Goldie, Mustafa Yazgan, Joe Wenjie Jiang… in Nature (2022)

Article

EBV miRNAs BART11 and BART17-3p promote immune escape through the enhancer-mediated transcription of PD-L1

Epstein-Barr virus (EBV) is reportedly the first identified human tumor virus, and is closely related to the occurrence and development of nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), and several ly...

Jie Wang, Junshang Ge, Yian Wang, Fang **ong, Jiayue Guo… in Nature Communications (2022)

Article

Single cell atlas for 11 non-model mammals, reptiles and birds

The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells c...

Dongsheng Chen, Jian Sun, Jiacheng Zhu, **angning Ding… in Nature Communications (2021)

Article

Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets

Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of gastric cancer. However, little is known about the genomic features of this disease. We perform whole-exome sequencing ...

Jun Lu, Yongfeng Ding, Yanyan Chen, Junjie Jiang, Yiran Chen… in Nature Communications (2021)

Article

Irrelevance of linear controllability to nonlinear dynamical networks

There has been tremendous development in linear controllability of complex networks. Real-world systems are fundamentally nonlinear. Is linear controllability relevant to nonlinear dynamical networks? We ident...

Junjie Jiang, Ying-Cheng Lai in Nature Communications (2019)

Article

Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment

A growing emphasis in anticancer drug discovery efforts has been on targeting histone acetylation modulators. Here we comprehensively analyze the genomic alterations of the genes encoding histone acetylation m...

Zhongyi Hu, Junzhi Zhou, Junjie Jiang, Jiao Yuan, Youyou Zhang… in Nature Communications (2019)

Article

(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats

Chronic cerebral hypoperfusion is a pathological state that is associated with the cognitive impairments in vascular dementia. Oxiracetam is a nootropic drug that is commonly used to treat cognitive deficits o...

Wan li, Huihui Liu, Hanjie Jiang, Chen Wang, Yongfei Guo, Yi Sun… in Scientific Reports (2017)

Article

HIV-1 CRF01_AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China

The goal of this study was to assess risk factors associated with HIV/AIDS progression. Between May 2007 and December 2014, 114 subjects were enrolled in Wuxi City and examined every 6 months. The pol gene sequen...

Minjie Chu, Wuhong Zhang, Xuan Zhang, Wenjie Jiang, … in Scientific Reports (2017)

Article

A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

Estrogen receptor signalling plays important regulatory roles in multiple mammalian physiological processes. Dysregulation of estrogen receptor (ER) expression and/or its associated signalling pathway is stron...

Liangcai Wu, Qianqian Xu, Haohai Zhang, Ming Li, Chengpei Zhu… in Scientific Reports (2016)

Article

Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson’s Disease

Safflower has long been used to treat cerebrovascular diseases in China. We previously reported that kaempferol derivatives of safflower can bind DJ-1, a protein associated with Parkinson’s disease (PD) and fl...

Rutong Ren, Chunyan Shi, **g Cao, Yi Sun, **n Zhao, Yongfei Guo… in Scientific Reports (2016)

Article

Construction and analysis of dynamic transcription factor regulatory networks in the progression of glioma

The combinatorial cross-regulation of transcription factors (TFs) plays an important role in cellular identity and function; however, the dynamic regulation of TFs during glioma progression remains largely unk...

Yongsheng Li, Tingting Shao, Chunjie Jiang, **g Bai, Zishan Wang… in Scientific Reports (2015)

Article

Preliminary identification of palaeofloods with the alkane ratio C₃₁/C₁₇ and their potential link to global climate changes

A major challenge in palaeohydrology is the extraction of continuous palaeoflood information from geophysical records. A high-resolution sediment core off the Minjiang estuary area in the Taiwan Strait, SE Chi...

Jianjun Wang, Liqi Chen, Li Li, Jianhua He, Jian Chen, Chuanjie Jiang… in Scientific Reports (2014)