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Article
Open AccessEvaluation of vaccine candidates against Rhodococcus equi in BALB/c mice infection model: cellular and humoral immune responses
Rhodococcus equi (R. equi) is a zoonotic opportunistic pathogen that mainly causes fatal lung and extrapulmonary abscesses in foals and immunocompromised individuals. To date, no commercial vaccine against R. equ...
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Article
Open AccessReformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation
Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this. Here, we reformu...
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Article
IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor characterized by a highly heterogeneous and immunosuppressive tumor microenvironment (TME). The symbiotic interactions between glioblasto...
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Article
Determining the optimal pharmacokinetic modelling and simplified quantification method of [18F]AlF-P16-093 for patients with primary prostate cancer (PPCa)
This paper discusses the optimization of pharmacokinetic modelling and alternate simplified quantification method for [18F]AlF-P16-093, a novel tracer for in vivo imaging of prostate cancer.
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Article
Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells
Lymph nodes are crucial organs of the adaptive immune system, orchestrating T cell priming, activation and tolerance. T cell activity and function are highly regulated by lymph nodes, which have a unique struc...
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Article
Open AccessSearch for a third-generation leptoquark coupled to a τ lepton and a b quark through single, pair, and nonresonant production in proton-proton collisions at \( \sqrt{s} \) = 13 TeV
A search is presented for a third-generation leptoquark (LQ) coupled exclusively to a τ lepton and a b quark. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV recorded w...
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Article
Open AccessP. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the risk of BPH, but the specific mechanism remains unclear. This study a...
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Article
Open AccessStructures of the mumps virus polymerase complex via cryo-electron microscopy
The viral polymerase complex, comprising the large protein (L) and phosphoprotein (P), is crucial for both genome replication and transcription in non-segmented negative-strand RNA viruses (nsNSVs), while stru...
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Article
Open AccessSearch for exotic decays of the Higgs boson to a pair of pseudoscalars in the \(\upmu \upmu \text{ b } \text{ b } \) and \(\uptau \uptau \text{ b } \text{ b } \) final states
A search for exotic decays of the Higgs boson ( \(\text {H}\) H ) with a mass...
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Article
Open AccessMeasurement of the primary Lund jet plane density in proton-proton collisions at \( \sqrt{\textrm{s}} \) = 13 TeV
A measurement is presented of the primary Lund jet plane (LJP) density in inclusive jet production in proton-proton collisions. The analysis uses 138 fb−1 of data collected by the CMS experiment at ...
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Article
Open AccessInclusive and differential cross section measurements of \( \textrm{t}\overline{\textrm{t}}\textrm{b}\overline{\textrm{b}} \) production in the lepton+jets channel at \( \sqrt{s} \) = 13 TeV
Measurements of inclusive and normalized differential cross sections of the associated production of top quark-antiquark and bottom quark-antiquark pairs, ...
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Article
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities
Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly available large-scale studies. We established a comprehensive multiomics cohort of 773 ...
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Article
Open AccessSearch for dark matter particles in W+W− events with transverse momentum imbalance in proton-proton collisions at \( \sqrt{s} \) = 13 TeV
A search for dark matter particles is performed using events with a pair of W bosons and large missing transverse momentum. Candidate events are selected by requiring one or two leptons (ℓ = electrons or muons). ...
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Article
Open AccessPan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss
Estrogen deficiency-mediated hyperactive osteoclast represents the leading role during the onset of postmenopausal osteoporosis. The activation of a series of signaling cascades triggered by RANKL-RANK interac...
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Article
A general copper-catalysed enantioconvergent C(sp3)–S cross-coupling via biomimetic radical homolytic substitution
Although α-chiral C(sp3)–S bonds are of enormous importance in organic synthesis and related areas, the transition-metal-catalysed enantioselective C(sp3)–S bond construction still represents an underdeveloped do...
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Article
Open AccessRNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling
Metastasis is one of the leading cause contributes to treatment failure and poor prognosis of hepatocellular carcinoma (HCC) patients. The underlying mechanism of HCC metastasis remains to be determined. Altho...
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Article
Open AccessComparison of long-term radial artery occlusion via distal vs. conventional transradial access (CONDITION): a randomized controlled trial
The distal transradial access (dTRA) has become an attractive and alternative access to the conventional transradial access (TRA) for cardiovascular interventional diagnosis and/or treatment. There was a lack ...
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Article
Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis
Morphological rearrangement of the endoplasmic reticulum (ER) is critical for metazoan mitosis. Yet, how the ER is remodeled by the mitotic signaling remains unclear. Here, we report that mitotic Aurora kinase...
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Article
Open AccessMeasurement of the τ lepton polarization in Z boson decays in proton-proton collisions at \( \sqrt{s} \) = 13 TeV
The polarization of τ leptons is measured using leptonic and hadronic τ lepton decays in Z → τ+τ− events in proton-proton collisions at ...
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Article
O-GlcNAcylation of melanophilin enhances radiation resistance in glioblastoma via suppressing TRIM21 mediated ubiquitination
The molecular mechanism of glioblastoma (GBM) radiation resistance remains poorly understood. The aim of this study was to elucidate the potential role of Melanophilin (MLPH) O-GlcNAcylation and the specific m...
