1,202 Result(s)
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**n-shu Zhang
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Article
Negative symptoms and neurocognition in drug-naïve schizophrenia: moderating role of plasma neutrophil gelatinase-associated lipocalin (NGAL) and interferon-gamma (INF-γ)
Previous studies reported that peripheral inflammation was associated with cognitive performance and brain structure in schizophrenia. However, the moderating effect of inflammation has not been extensively st...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and pathogenicity. Given the emergence of increasingly drug-resistant str...
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Corporate sustainability: the role of environmental taxes in ESG performance
Exploring the influence of environmental taxes on ESG performance is crucial for fostering enterprise sustainability. This study presents an investigation of the influence of environmental taxation on corporat...
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Open AccessGenome-wide identification and analysis of monocot-specific chimeric jacalins (MCJ) genes in Maize (Zea mays L.)
The monocot chimeric jacalins (MCJ) proteins, which contain a jacalin-related lectin (JRL) domain and a dirigent domain (DIR), are specific to Poaceae. MCJ gene family is reported to play an important role in ...
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Open AccessZero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutation effects is critical in biotechnology and biomedicine, but remains a fundamental chall...
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Article
Crenobacter oryzisoli sp. nov., a novel phosphate-solubilizing bacterium isolated from the paddy soil
Two Gram-staining-negative, facultative anaerobic, rod-shaped and phosphate-solubilizing strains designated SG2303T and SG2305, were isolated from paddy soil in China. Phylogenetic analysis based on 16 S rRNA gen...
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Experimental and Theoretical Study on Crack Growth Using Rock-Like Resin Samples Containing Inherent Fissures and its Numerical Assessment
The initiation and propagation of microcracks along preexisting fissures is one of the typical failure modes for inherently fractured rocks in geotechnical engineering. To better capture the growth of such mic...
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Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis
Angiogenesis plays a critical role in many pathological processes, including irreversible blindness in eye diseases such as retinopathy of prematurity. Endothelial mitochondria are dynamic organelles that unde...
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The ALMaQUEST Survey XV: The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics
The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies, which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar medium. We...
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From synthesis to applications of biomolecule-protected luminescent gold nanoclusters
Gold nanoclusters (AuNCs) are a class of novel luminescent nanomaterials that exhibit unique properties of ultra-small size, featuring strong anti-photo-bleaching ability, substantial Stokes shift, good biocom...
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Article
Solid solution strategy modulated defects engineering of (Cr1-xVx)2AlC MAX phase toward superior electromagnetic wave absorption
Defects engineering is an effective strategy for manipulating electromagnetic parameters and enhancing electromagnetic wave (EMW) absorption capacity. However, the relationship between them is not clear, espec...
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Molecular docking-aided AIEgen design: concept, synthesis and applications
Aggregate-induced emission luminogens (AIEgens) have been widely used in biological imaging, chemical sensing, and disease treatments. The rational design and construction of AIEgens have received considerable...
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Article
AI for organic and polymer synthesis
Recent years have witnessed the transformative impact from the integration of artificial intelligence with organic and polymer synthesis. This synergy offers innovative and intelligent solutions to a range of ...
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Open AccessWTCRNet: a wavelet transform and contrastive regularization network for sonar denoising by self-supervision
In the field of underwater acoustics, forward-looking sonar represents a pivotal tool for acquiring subaqueous imagery. However, this technique is susceptible to the inherent ambient noise prevalent in underwa...
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Open AccessSMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
Endocrine resistance poses a significant clinical challenge for patients with hormone receptor-positive and human epithelial growth factor receptor 2-negative (HR + HER2−) breast cancer. Dysregulation of estro...
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Open AccessCargo-eliminated osteosarcoma-derived small extracellular vesicles mediating competitive cellular uptake for inhibiting pulmonary metastasis of osteosarcoma
Osteosarcoma (OS) derived small extracellular vesicles (OS-sEVs) have been shown to induce the formation of cancer-associated fibroblasts (CAFs), characterized by elevated pro-inflammatory factor expression an...
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Open AccessNoninvasive prediction of lymph node metastasis in pancreatic cancer using an ultrasound-based clinicoradiomics machine learning model
This study was designed to explore and validate the value of different machine learning models based on ultrasound image-omics features in the preoperative diagnosis of lymph node metastasis in pancreatic canc...
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Open AccessA nomogram for predicting hemorrhagic shock in pediatric patients with multiple trauma
The timely detection and management of hemorrhagic shock hold paramount importance in clinical practice. This study was designed to establish a nomogram that may facilitate early identification of hemorrhagic ...
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T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin
T cell engaging bispecific antibodies (TCBs) have recently become significant in cancer treatment. In this study we developed MSLN490, a novel TCB designed to target mesothelin (MSLN), a glycosylphosphatidylin...
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Open AccessASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
The human methyltransferase and transcriptional coactivator MLL4 and its paralog MLL3 are frequently mutated in cancer. MLL4 and MLL3 monomethylate histone H3K4 and contain a set of uncharacterized PHD fingers...
