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Article
Open AccessGestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice
Valproic acid (VPA) is one of the most effective antiepileptic drugs, and exposing animals to VPA during gestation has been used as a model for autism spectrum disorder (ASD). Numerous studies have shown that ...
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Article
Clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma
The clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma (ND-DLBCL) remains largely unexplored. One hundred ND-DLBCL patients were consecutively enrolled as training c...
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Article
Selection dictates the distance pattern of similarity in trees and soil fungi across forest ecosystems
How the four major processes affecting community assembly—selection, dispersal, drift, and diversification—solely or jointly shape co-occurring assemblages of macro- and microorganisms at the same scales remai...
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Article
Analysis of CCND3 mutations in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), accounts for 30–40% of newly diagnosed lymphomas, has an overall cure rate of approximately 60%. Despite previous reports suggesting a negative prognostic association bet...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Article
Lax pair, conservation laws, breather-to-soliton transitions and modulation instability for a coupled extended modified Korteweg-de Vries system in a fluid
The modified Korteweg-de Vries-type equations can be used to describe the interfacial waves in a fluid, elastic quasi-plane waves in a lattice, and Alfvén waves in a collisionless plasma. In this paper, we inv...
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Article
Nickel-catalyzed carbonylative four-component 1,4-dicarbofunctionalization of 1,3-enynes
An efficient Ni-catalyzed four-component 1,4-carbocarbonylation of 1,3-enynes with activated alkyl halides and arylboronic acids under atmospheric pressure of CO is presented. By tuning the electronic and ster...
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Article
Synthesis, Structure, and Antitumor Activities of Dehydroepiandrosteronyl Derivatives with 1,2,3-Triazoles
Objective: Dehydroepiandrosterone plays an important role in the human beings due to its ability to be converted into androgens and oestrogens. The aim of this paper is to synthesize a series of novel dehydroepia...
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Article
Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity
The CRISPR system is an adaptive immune system found in prokaryotes that defends host cells against the invasion of foreign DNA1. As part of the ongoing struggle between phages and the bacterial immune system, th...
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Article
Highly Compressible and Lightweight Al2O3/PCNF@ANF Aerogels for Effective Oil Adsorption and Separation
Due to the lightweight feature, superior hydrophobic and oleophilic property, as well as remarkable adsorption capability, carbon-based aerogels have become appealing adsorbents for removing leaking oils and t...
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Article
Open AccessSpatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
Aging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through ...
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Article
Open AccessImpact of climate change on the global circulation of West Nile virus and adaptation responses: a sco** review
West Nile virus (WNV), the most widely distributed flavivirus causing encephalitis globally, is a vector-borne pathogen of global importance. The changing climate is poised to reshape the landscape of various ...
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Article
Clinical characteristics and prognosis of patients with newly diagnosed primary central nervous system lymphoma: a multicentre retrospective analysis
Bruton’s tyrosine kinase inhibitors (BTKi) exhibit superior efficacy in relapsed/refractory primary central nervous system lymphoma (PCNSL), but few studies have evaluated patients with newly diagnosed PCNSL, ...
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Article
Open AccessRisk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis: a nationwide retrospective study in China
Pediatric antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a life-threatening systemic vasculitis featured by liability to renal involvement. However, there are few studies on the risk factor...
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Article
Lactate ameliorates palmitate-induced impairment of differentiative capacity in C2C12 cells through the activation of voltage-gated calcium channels
Palmitic acid (PA), a saturated fatty acid enriched in high-fat diet, has been implicated in the development of skeletal muscle regeneration dysfunction. This study aimed to examine the effects and mechanisms ...
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Article
Distinct element method simulation of mechanical properties of material layer of pellet belt roasting machine
The thick layer and graded feeding technology of a belt roasting machine is an effective method for improving the production efficiency and quality index of pellet production, and a reasonable design of the me...
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Article
Open AccessFine-map** analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unkn...
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Article
Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway
To investigate the mechanism of induction of ferroptosis by brazilin in breast cancer cells.
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Article
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Proteolysis targeting chimeras (PROTACs) have emerged as revolutionary anticancer therapeutics that degrade disease-causing proteins. However, the anticancer performance of PROTACs is often impaired by their i...
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Article
Open AccessOral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes
The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of t...
