157 Result(s)
within
**n-gang Li
Biomedicine
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Article
Recognition of human colon cancer by T cells transduced with a chimeric receptor gene
Transduction with chimeric T-cell receptor genes can be used to redirect primary T lymphocytes to recognize specific antigens (Ags), including ovarian and breast cancer Ags. To extend this approach to colon ca...
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Article
Intestinal microflora in rats with ischemia/reperfusion liver injury
Objectives: To investigate the intestinal microflora status related to ischemia/reperfusion (I/R) liver injury and explore the possible mechanism. Methods: Specific pathogen free grade Sprague-Dawley rats were...
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Article
Melatonin attenuates 1-methyl-4-phenylpyridinium-induced PC12 cell death
To explore the effect of melatonin on PC12 cell death induced by 1-methyl-4-phenylpyridinium (MPP+).
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Article
A first order system model of fracture healing
A first order system model is proposed for simulating the influence of stress stimulation on fracture strength during fracture healing. To validate the model, the diaphyses of bilateral tibiae in 70 New Zealan...
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Article
Antisense oligonucleotides-induced local blockade of T-bet expression leads to airway inflammation in rats
To explore whether local blockade of T-box expressed in T cells (T-bet) expression in the lungs could lead to airway inflammation.
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Article
Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol
To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO).
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Article
Production and characterization of monoclonal antibodies of shrimp White spot syndrome virus envelope protein VP28
BALB/c mice were immunized with purified White spot syndrome virus (WSSV). Six monoclonal antibody cell lines were selected by ELISA with VP28 protein expressed in E. coli. in vitro neutralization experiments ...
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Article
Dendritic cell-based immunotherapy for malignant glioma
The immunotherapy for malignant glioma faces unique difficult, due to some anatomical and immunological characteristics including the existence of blood brain barrier, the absence of lymphatic tissues and dend...
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Article
Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivo
To evaluate the role of thrombin-activated microglia in the neurodegeneration of nigral dopaminergic neurons in the rat substantia nigra (SN) in vivo.
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Article
PKC promotes proliferation of airway smooth muscle cells by regulating cyclinD1 expression in asthmatic rats
To determine whether protein kinase C (PKC) has any effect on the expression of cyclinD1, a key regulator of growth control and G1/S transition, and to investigate the underlying molecular mechanisms of PKC invol...
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Article
Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells
Perospirone (PER) is a novel atypical antipsychotic drug for the treatment of schizophrenia and other psychotic disorders. The multidrug resistance transporter, P-glycoprotein (Pgp), is involved in the efflux ...
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Article
Subconjunctival sustained release 5-fluorouracil for glaucoma filtration surgery
To determine the release characteristics of a 5-fluorouracil-loaded poly (lactic acid) disc (5-FU-PLA-DS) and the effect of sustained drug delivery on the success of glaucoma filtration surgery in rabbit eyes.
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Article
Adenovirus-mediated delivery of p27KIP1 to prevent wound healing after experimental glaucoma filtration surgery
The aim of the study was to evaluate the outcome of adenovirus-mediated p27KIP1 (Ad-p27) expression on wound healing after filtration surgery and to investigate the inhibition of cell proliferation induced by Ad-...
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Article
Tentative identification of glycerol dehydrogenase as Escherichia coli K1 virulence factor cglD and its involvement in the pathogenesis of experimental neonatal meningitis
Escherichia coli (E. coli) is the most common gram-negative organism causing meningitis during the neonatal period. The mechanism involved in the pathogenesis of E. coli meningitis remains unclear. We previously ...
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Article
Cyclic electron flow around photosystem I is required for adaptation to high temperature in a subtropical forest tree, Ficus concinna
Dissipation mechanisms of excess photon energy under high-temperature stress were studied in a subtropical forest tree seedling, Ficus concinna. Net CO2 assimilation rate decreased to 16% of the control after 20 ...
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Article
The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells
To test the hypothesis that the epoxyeicosatrienoic acid (EET)-induced transactivation of EGF-R depends on the activation of metalloproteinases and the subsequent release of HB-EGF in cancer cells.
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Article
Neural circuits and temporal plasticity in hindlimb representation of rat primary somatosensory cortex: revisited by multi-electrode array on brain slices
The well-established planar multi-electrode array recording technique was used to investigate neural circuits and temporal plasticity in the hindlimb representation of the rat primary somatosensory cortex (S1 ...
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Article
Distinct neural mechanisms underlying acute and repeated administration of antipsychotic drugs in rat avoidance conditioning
Acute antipsychotic treatment disrupts conditioned avoidance responding, and repeated treatment induces a sensitization- or tolerance-like effect. However, the neurochemical mechanisms underlying both acute an...
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Article
Wnt4, the first member of the Wnt family identified in Schistosoma japonicum, regulates worm development by the canonical pathway
The Wnt signaling pathway is an evolutionarily conserved signal transduction pathway used extensively during animal development. We aim, by increasing our understanding of the Wnt signaling pathway, to find a ...
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Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant glioma
Malignant gliomas display over-expression of the receptor tyrosine kinase EphA2. However, expression levels of the EphA2 ligand, EphrinA1, have not been fully elucidated. Seventy-eight patients with primary gl...
