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Article
Open AccessCharacterize direct protein interactions with enrichable, cleavable and latent bioreactive unnatural amino acids
Latent bioreactive unnatural amino acids (Uaas) have been widely used in the development of covalent drugs and identification of protein interactors, such as proteins, DNA, RNA and carbohydrates. However, it i...
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Article
MEDMCN: a novel multi-modal EfficientDet with multi-scale CapsNet for object detection
Object detection in real-world scenarios with multi-modal inputs is crucial for some safety-critical systems, such as autonomous driving, security monitoring, and traffic management. Despite significant progre...
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Article
Metagenomic analysis of individual mosquito viromes reveals the geographical patterns and drivers of viral diversity
Mosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Here, using a ...
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Article
Open AccessPopulation-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area
Deleterious BRCA1/2 (BRCA) mutation raises the risk for BRCA mutation-related malignancies, including breast, ovarian, prostate, and pancreatic cancer. Germline variation of BRCA exhibits substantial ethnical div...
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Article
Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16–F10, MC38 and Hep1-6 Tumor Models
To investigate the anti-tumor effects of Pien Tze Huang (PZH) in mouse models of B16–F10 melanoma, MC38 colorectal cancer, Hep1-6 hepatocellular carcinoma and chemically induced hepatocellular carcinoma model.
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Article
Three-Dimensional Sound Source Location Algorithm for Subsea Leakage Using Hydrophone
Leakages from subsea oil and gas equipment cause substantial economic losses and damage to marine ecosystem, so it is essential to locate the source of the leak. However, due to the complexity and variability ...
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Article
Open AccessPerioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children: analysis of 571 patients
Surgery plays an important role in the treatment of neuroblastoma. Perioperative complications may impact the course of neuroblastoma treatment. To date, comprehensive analyses of complications and risk factor...
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Article
Open AccessGlycosides from the leaves of Fraxinus Hubeiensis
Fraxinus hubeiensis is a plant endemic to China and widely used as folk medicine to treat various diseases. However, its chemical constituents have never been reported sufficiently. Thus, the primary objective of...
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Article
Open AccessCopper assisted sequence-specific chemical protein conjugation at a single backbone amide
Direct, site-specific methods of protein functionalization are highly desirable for biotechnology. However, such methods are challenging due to the difficulty of chemically differentiating a single site within...
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Article
The Application of Deep Brain Stimulation for Parkinson’s Disease on the Motor Pathway: A Bibliometric Analysis across 10 Years
Since its initial report by James Parkinson in 1817, Parkinson’s disease (PD) has remained a central subject of research and clinical advancement. The disease is estimated to affect approximately 1% of adults ...
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Article
Measurement of Br(n,γ) cross sections up to stellar s-process temperatures at the CSNS Back-n
The neutron capture cross sections ( \({n,\gamma }\) n , ...
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Article
Open AccessSAPT: a synchrotron-based proton therapy facility in Shanghai
Because of its excellent dose distribution, proton therapy is becoming increasingly popular in the medical application of cancer treatment. A synchrotron-based proton therapy facility was designed and construc...
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Article
Localized high-concentration electrolytes for lithium metal batteries: progress and prospect
With the increasing development of digital devices and electric vehicles, high energy-density rechargeable batteries are strongly required. As one of the most promising anode materials with an ultrahigh specif...
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Article
Open AccessHost heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation
SARS-CoV-2 infection causes spike-dependent fusion of infected cells with ACE2 positive neighboring cells, generating multi-nuclear syncytia that are often associated with severe COVID. To better elucidate the...
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Special Issue: Theory and Simulation of Macromolecules
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Article
Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel
Voltage-gated sodium channel 1.7 (Nav1.7) remains one of the most promising drug targets for pain relief. In the current study, we conducted a high-throughput screening of natural products in our in-house comp...
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Article
Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein
The Omicron subvariant BA.2 has become the dominant circulating strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in many countries. Here, we have characterized structural, functional and ...
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Article
Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia
Mismatch repair (MMR) deficiency has been linked to thiopurine resistance and hypermutation in relapsed acute lymphoblastic leukemia (ALL). However, the repair mechanism of thiopurine-induced DNA damage in the...
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Article
Efficient all-thermally evaporated perovskite light-emitting diodes for active-matrix displays
Perovskite light-emitting diodes (PeLEDs) have recently demonstrated great potential for next-generation displays. Fabricating PeLEDs by scalable and well-established thermal evaporation—the technique used for...
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Article
Enhanced immobility of Pb(II) during ferrihydrite-Pb(II) coprecipitates aging impacted by malic acid or phosphate
Metastable ferrihydrite is omnipresent in environments and can influence the fate of Pb(II) during ferrihydrite transformation. Ferrihydrite is rarely pure and often coexists with impurities, which may influen...
