32 Result(s)
within
**n-Yue Yan
Biomedicine, general
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Article
Multiple dose pharmacokinetics of risperidone and 9-hydroxyrisperidone in Chinese female patients with schizophrenia
To study the multiple dose clinical pharmacokinetics of risperidone and its main active metabolite, 9-hydroxyrisperidone, in Chinese female patients with schizophrenia.
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Article
Reversal of hyperglycemia by protein transduction of NeuroD in vivo
To test whether the neurogenic differentiation (NeuroD) protein could alleviate symptoms of diabetes mellitus by its transduction activity in vivo.
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Article
Open AccessSensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis
A subset of patients of amyotrophic lateral sclerosis (ALS) present with mutation of Cu/Zn superoxide dismutase 1 (SOD1), and such mutants caused an ALS-like disorder when expressed in rodents. These findings ...
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Article
Open AccessLimitations in SELDI-TOF MS whole serum proteomic profiling with IMAC surface to specifically detect colorectal cancer
Surface enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) analysis on serum samples was reported to be able to detect colorectal cancer (CRC) from normal or control patie...
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Article
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1
Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.
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Article
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population
Qing Wang and colleagues report a genome-wide association study for coronary artery disease (CAD) in a Chinese Han population. They identify a locus on chromosome 6p24.1 newly associated with CAD.
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Article
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2
Dai Zhang and colleagues report a genome-wide association study for schizophrenia in the Han Chinese population. They identify a new susceptibility locus at 11p11.2 and also identify a locus at 6p21-22.1 in th...
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Article
Overexpression of microRNA OsmiR397 improves rice yield by increasing grain size and promoting panicle branching
Overexpression of a microRNA in rice increases yield, suggesting new routes to crop improvement.
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Article
Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
Nat. Genet. 42, 759–763 (2010); published online 22 August 2010; corrected after print 27 August 2014 In contrast to the version of this article initially published, the authors now find no evidence to support...
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Article
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations
Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and a...
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Article
Open AccessCopy number variation analysis based on AluScan sequences
AluScan combines inter-Alu PCR using multiple Alu-based primers with opposite orientations and next-generation sequencing to capture a huge number of Alu-proximal genomic sequences for investigation. Its requirem...
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Article
Open AccessEfficacy and safety of electroacupuncture with different acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial
Many patients experience nausea and vomiting during chemotherapy treatment. Evidence demonstrates that electroacupuncture is beneficial for controlling chemotherapy-induced nausea and vomiting (CINV). However,...
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Article
Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells
The formation of fat-laden foam cells, contributing to the fatty streaks of the plaques of atheroma, is the critical early process in atherosclerosis. The previous study demonstrated that vascular smooth muscl...
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Article
Marine-derived chromopeptide A, a novel class I HDAC inhibitor, suppresses human prostate cancer cell proliferation and migration
Histone deacetylases (HDACs), especially HDAC1, 2, 3 and 4, are abundantly expressed and over-activated in prostate cancer that is correlated with the poor prognosis. Thus, inhibition of HDAC activity has emer...
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Article
In vitro antioxidant activity of phenolic-enriched extracts from Zhang** Narcissus tea cake and their inhibition on growth and metastatic capacity of 4T1 murine breast cancer cells
Phenolics, as the main bioactive compounds in tea, have been suggested to have potential in the prevention of various human diseases. However, little is known about phenolics and their bioactivity in Zhang**...
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Article
Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay
SMARCA2 is a critical catalytic subunit of the switch/sucrose non-fermenting (SWI/SNF) chromatin remodeling complexes. Dysregulation of SMARCA2 is associated with several diseases, including some cancers. SMAR...
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Article
Comprehensive genetic diagnosis of patients with Duchenne/Becker muscular dystrophy (DMD/BMD) and pathogenicity analysis of splice site variants in the DMD gene
Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are caused by mutations in the DMD gene. The aim of this study is to identify pathogenic DMD variants in probands and reduce the risk of recur...
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Article
Facile synthesis of Au embedded CuOx-CeO2 core/shell nanospheres as highly reactive and sinter-resistant catalysts for catalytic hydrogenation of p-nitrophenol
Exploring cost-effective catalysts with high catalytic performance and long-term stability has always been a general concern for environment protection and energy conversion. Here, Au nanoparticles (NPs) embed...
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Article
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation
Myocardial infarction (MI) leads to the loss of cardiomyocytes, left ventricle dilation and cardiac dysfunction, eventually develo** into heart failure. Mzb1 (Marginal zone B and B1 cell specific protein 1) ...
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Article
Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway
The neonatal heart possesses the ability to proliferate and the capacity to regenerate after injury; however, the mechanisms underlying these processes are not fully understood. Melatonin has been shown to pro...
