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Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

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  1. Article

    The novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function

    To investigate the effects of iptakalim on endothelial dysfunction induced by insulin resistance (IR) and to determine whether iptakalim improved IR associated with hypertension in fructose-fed rats (FFRs) and...

    Yu Wang, Fu-hu Zeng, Chao-liang Long, Zhi-yuan Pan in Acta Pharmacologica Sinica (2011)

  2. Article

    Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis

    To investigate the effects of M3, a derivative of huperzine A, on the apoptosis induced by sodium nitroprusside (SNP) in PC12 cells.

    Na Ning, **-feng Hu, Yu-he Yuan, **n-yuan Zhang, Jun-gui Dai in Acta Pharmacologica Sinica (2012)

  3. Article

    Characterization of the immune responses elicited by baculovirus-based vector vaccines against influenza virus hemagglutinin

    To compare the specific immune responses elicited by different baculovirus vectors in immunized mice.

    Zhi-peng Hu, Juan Yin, Yuan-yuan Zhang, Shu-ya Jia in Acta Pharmacologica Sinica (2012)

  4. Article

    Anisomycin induces glioma cell death via down-regulation of PP2A catalytic subunit in vitro

    To examine the effects of anisomycin on glioma cells and the related mechanisms in vitro.

    Jun-yang Li, Jia-yuan Huang, Meng Li, Han Zhang, Biao **ng in Acta Pharmacologica Sinica (2012)

  5. Article

    Therapeutic effects of mesenchymal stem cell-derived microvesicles on pulmonary arterial hypertension in rats

    Microvesicles (MVs) are nanoscale membrane fragments released from virtually all cell types upon activation or apoptosis, and may contribute to the beneficial effects of stem cell therapy. In this study, we in...

    Jian-ying Chen, Ran An, Zhen-jun Liu, **-ju Wang in Acta Pharmacologica Sinica (2014)

  6. Article

    Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways

    Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan found in traditional Chinese herbs, has been determined to exhibit a variety of pharmacological activities, including anti-tumor, anti-inflammation, n...

    Ruo-ming Wu, Yan-yan Sun, Ting-ting Zhou, Zhi-yuan Zhu in Acta Pharmacologica Sinica (2014)

  7. Article

    Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells

    To study the function and mechanism of bigelovin, a sesquiterpene lactone from the flower of Chinese herb Inula hupehensis, in regulating JAK2/STAT3 signaling and cancer cell growth.

    Hao-hao Zhang, Shan Kuang, Ying Wang, **ao-xiao Sun, Yuan Gu in Acta Pharmacologica Sinica (2015)

  8. Article

    Open Access

    Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease

    Diabetic kidney disease (DKD) is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal disease with limited treatment options. Wogonin is a flavonoid derived from the...

    Xue-qi Liu, Ling Jiang, Yuan-yuan Li, Yue-bo Huang, Xue-ru Hu in Acta Pharmacologica Sinica (2022)