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Article
Open AccessChromosome-level genome assembly of an oligophagous leaf beetle Ophraella communa (Coleoptera: Chrysomelidae)
The leaf beetle Ophraella communa LeSage (Coleoptera: Chrysomelidae) is an effective biological control agent of the common ragweed. Here, we assembled a chromosome-level genome of the O. communa by combining Ill...
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Article
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Article
Metabolome and Genome Analysis of a Novel Endophytic Fungus Aureobasidium pullulans KB3: Discovery of Polyketones and Polyketone Biosynthesis Pathway
Endophytic fungi associated with plants may contain undiscovered bioactive compounds. Under standard laboratory conditions, most undiscovered compounds are inactive, whereas their production could be stimulate...
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Article
T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin
T cell engaging bispecific antibodies (TCBs) have recently become significant in cancer treatment. In this study we developed MSLN490, a novel TCB designed to target mesothelin (MSLN), a glycosylphosphatidylin...
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Article
Open AccessPhysical frailty, genetic predisposition, and incident dementia: a large prospective cohort study
Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical f...
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Article
Open AccessA study on the application of radiomics based on cardiac MR non-enhanced cine sequence in the early diagnosis of hypertensive heart disease
The prevalence of hypertensive heart disease (HHD) is high and there is currently no easy way to detect early HHD. Explore the application of radiomics using cardiac magnetic resonance (CMR) non-enhanced cine ...
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Article
Inhalable spray-dried porous microparticles containing dehydroandrographolide succinate phospholipid complex capable of improving and prolonging pulmonary anti-inflammatory efficacy in mice
Due to the unique physiological barriers within the lungs, there are considerable challenges in develo** drug delivery systems enabling prolonged drug exposure to respiratory epithelial cells. Here, we repor...
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Article
Metal–organic framework-derived CoSe2@N-doped carbon nanocubes for high-performance lithium-ion capacitors
Cobalt selenide (CoSe2) has garnered considerable attention as a prospective anode candidate for advanced lithium-ion storage, prompting comprehensive investigations. However, CoSe2-based anodes usually suffer fr...
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Article
Open AccessFurther clarification of cognitive processes of prospective memory in schizophrenia by comparing eye-tracking and ecologically-valid measurements
The aim of this study is to compare ecologically-valid measure (the Cambridge Prospective Memory Test, CAMPROMPT) and laboratory measure (eye-tracking paradigm) in assessing prospective memory (PM) in individu...
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Article
Open AccessAn algorithm for simplified hepatitis C virus treatment with non-specialist care based on nation-wide data from Taiwan
Both European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases and the Infectious Diseases Society of America (AASLD-IDSA) guidelines recommend simplified ...
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Article
Nitrogen-rich hollow carbon microspheres with tunable shell thicknesses for enhanced CO2 adsorption
Nitrogen-rich hollow carbon microspheres were successfully synthesized using resorcinol and formaldehyde as carbon sources, tetraethylenepentamine (TEPA) as a catalyst, and nitrogen source, with SiO2 microsphe...
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Article
Open AccessClinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency
The clinical manifestations of nonclassical 11beta-hydroxylase deficiency are very similar to those of non-classical 21-hydroxylase deficiency. For this study, we investigated the relationship between the clin...
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Article
Natural variation of Grain size 3 allele differentially functions in regulating grain length in xian/indica and geng/japonica rice
Grain yield in rice is largely determined by grain size. Grain Size 3 (GS3) is a major quantitative trait locus for grain size. The C–A natural variation in the second exon of GS3 was reported to play an importan...
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Article
Open AccessPatients with first-episode psychosis in northern Taiwan: neurocognitive performance and niacin response profile in comparison with schizophrenia patients of different familial loadings and relationship with clinical features
Examining patients with first-episode psychosis (FEP) provides opportunities to better understand the mechanism underlying these illnesses. By incorporating quantitative measures in FEP patients, we aimed to (...
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Article
Open AccessLow frequency of SLC26A4 c.919-2A > G variant among patients with nonsyndromic hearing loss in Yunnan of Southwest China
Gene variants are responsible for more than half of hearing loss, particularly in nonsyndromic hearing loss (NSHL). The most common pathogenic variant in SLC26A4 gene found in East Asian populations is c.919-2A >...
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Article
Open AccessFabrication of levofloxacin-loaded porcine acellular dermal matrix hydrogel and functional assessment in urinary tract infection
Bacterial cystitis, a commonly occurring urinary tract infection (UTI), is renowned for its extensive prevalence and tendency to recur. Despite the extensive utilization of levofloxacin as a conventional thera...
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Article
Open AccessCorrection to: Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency
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Article
Open AccessGenetic susceptibility modifies the association of long-term air pollution exposure on Parkinson’s disease
Inconsistent findings exist regarding the potential association between polluted air and Parkinson’s disease (PD), with unclear insights into the role of inherited sensitivity. This study sought to explore the...
