-
Article
Open AccessRepurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)
R-loop-triggered collateral single-stranded DNA (ssDNA) nuclease activity within Class 1 Type I CRISPR-Cas systems holds immense potential for nucleic acid detection. However, the hyperactive ssDNase activity ...
-
Article
Open AccessEvaluation of vaccine candidates against Rhodococcus equi in BALB/c mice infection model: cellular and humoral immune responses
Rhodococcus equi (R. equi) is a zoonotic opportunistic pathogen that mainly causes fatal lung and extrapulmonary abscesses in foals and immunocompromised individuals. To date, no commercial vaccine against R. equ...
-
Article
Experimental study on the mechanical properties of desert sand improved by the combination of additives and bio-cement
Bio-cement is a green and energy-saving building material that has attracted much attention in the field of ecological environment and geotechnical engineering in recent years. The aim of this study is to inve...
-
Article
Development and first-in-human study of PSMA-targeted PET tracers with improved pharmacokinetic properties
A series of new 68Ga-labeled tracers based on [68Ga]Ga-PSMA-617 were developed to augment the tumor-to-kidney ratio and reduce the activity accumulation in bladder, ultimately minimize radiation toxicity to the u...
-
Article
Open AccessMeasurements of electroweak W±Z boson pair production in association with two jets in pp collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
Measurements of integrated and differential cross-sections for electroweak W±Z production in association with two jets (W±Zjj) in proton-proton collisions are presented. The data collected by the ATLAS detector a...
-
Article
Open AccessAcetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors
Despite the importance of spliceosome core components in cellular processes, their roles in cancer development, including hepatocellular carcinoma (HCC), remain poorly understood. In this study, we uncover a c...
-
Article
Opportunities for production and property research of neutron-rich nuclei around N = 126 at HIAF
The study of nuclide production and its properties in the \({N}=126\) N ...
-
Article
Open AccessHuman gastric cancer progression and stabilization of ATG2B through RNF5 binding facilitated by autophagy-associated CircDHX8
The role of circDHX8 in the interplay between autophagy and gastric cancer (GC) progression remains unclear. In this study, we investigated the mechanism underlying the role of hsa_circ_003899 (circDHX8) in th...
-
Article
Preparation of PVA/GO/h-BN Janus Film with High Thermal Conductivity and Excellent Flexibility via a Density Deposition Self-assembly Method
Janus films with asymmetric physical/chemical properties have attracted considerable attention due to their promising applications in personal thermal management, electronic skins, sensors, actuators, etc. How...
-
Article
Open AccessDeciphering the role of zinc homeostasis in the tumor microenvironment and prognosis of prostate cancer
Dysregulation of zinc homeostasis is widely recognized as a hallmark feature of prostate cancer (PCa) based on the compelling clinical and experimental evidence. Nevertheless, the implications of zinc dyshomeo...
-
Article
Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis
Regulatory T cells (Tregs) prevent autoimmunity and contribute to cancer progression. They exert contact-dependent inhibition of immune cells through the production of active transforming growth factor-β1 (TGF...
-
Article
The subcommissural organ regulates brain development via secreted peptides
The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown...
-
Article
Multiphase evolution of a Li-pegmatite field from the Tashisayi area, Altyn Tagh, NW China: insights from a petrological, geochemical, and geochronological study
The Tashisayi Li deposit was newly discovered in the eastern part of the Tashisayi batholith, located in the Altyn Tagh region of Northwest China. A Li-rich composite pegmatite-aplite dyke (γ02) displays super...
-
Article
Fabrication of Tremella-Like Zn-Based Composite Coating with Improved Photocatalytic Degradation Performance and Robust Superhydrophobicity
In this paper, as-received Zn powder and as-prepared Zn@(ZnWO4/ZnO) core–shell powder were used as feedstocks for plasma spraying to prepare Zn-based composite coatings and nano-ZnO was co-deposited by chemical v...
-
Article
Open AccessTwo-dimensional materials for future information technology: status and prospects
Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...
-
Article
Open AccessMeasurement of t-channel production of single top quarks and antiquarks in pp collisions at 13 TeV using the full ATLAS Run 2 data sample
The production of single top quarks and top antiquarks via the t-channel exchange of a virtual W boson is measured in proton-proton collisions at a centre-of-mass energy of 13 TeV at the LHC using 140 fb−1 of ATL...
-
Article
Open AccessSearch for new particles in final states with a boosted top quark and missing transverse momentum in proton-proton collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
A search for events with one top quark and missing transverse momentum in the final state is presented. The fully hadronic decay of the top quark is explored by selecting events with a reconstructed boosted to...
-
Article
Chelator boosted tumor-retention and pharmacokinetic properties: development of 64Cu labeled radiopharmaceuticals targeting neurotensin receptor
Accumulating evidence suggests that neurotensin (NTS) and neurotensin receptors (NTSRs) play key roles in lung cancer progression by triggering multiple oncogenic signaling pathways. This study aims to develop...
-
Article
HDAC inhibitors as a potential therapy for chemotherapy-induced neuropathic pain
Cancer, a chronic disease characterized by uncontrolled cell development, kills millions of people globally. The WHO reported over 10 million cancer deaths in 2020. Anticancer medications destroy healthy and m...
-
Article
Open AccessElectron and photon efficiencies in LHC Run 2 with the ATLAS experiment
Precision measurements of electron reconstruction, identification, and isolation efficiencies and photon identification efficiencies are presented. They use the full Run 2 data sample collected by the ATLAS ex...
