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Article
Open AccessVolatile systematics in terrestrial igneous apatite: from microanalysis to decoding magmatic processes
Apatite has been recognized as a robust tool for the study of magmatic volatiles in terrestrial and extraterrestrial systems due to its ability to incorporate various volatile components and its common occurre...
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Article
Open AccessSirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria
Sirenians of the superorder Afrotheria were the first mammals to transition from land to water and are the only herbivorous marine mammals. Here, we generated a chromosome-level dugong (Dugong dugon) genome. A co...
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Article
Open AccessDiscovery of Loureirin analogues with colorectal cancer suppressive activity via regulating cell cycle and Fas death receptor
Chalcones and dihydrochalcones (DHCs) are important bioactive natural products (BNPs) isolated from traditional Chinese medicine. In this study, 13 chalcones were designed with the inspiration of Loureirin, a ...
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Article
Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
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Article
Open AccessLysine acetyltransferase 14 mediates TGF-β-induced fibrosis in ovarian endometrioma via co-operation with serum response factor
Fibrogenesis within ovarian endometrioma (endometrioma), mainly induced by transforming growth factor-β (TGF-β), is characterized by myofibroblast over-activation and excessive extracellular matrix (ECM) depos...
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Article
Open AccessMidbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice
The potential brain mechanism underlying resilience to socially transferred allodynia remains unknown. Here, we utilize a well-established socially transferred allodynia paradigm to segregate male mice into pa...
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Article
Open AccessSearch for new particles in final states with a boosted top quark and missing transverse momentum in proton-proton collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
A search for events with one top quark and missing transverse momentum in the final state is presented. The fully hadronic decay of the top quark is explored by selecting events with a reconstructed boosted to...
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Article
Open AccessSerum cytokines and creatinine/cystatin C ratio as prognostic biomarkers in advanced cancer patients treated with anti-PD-1/PD-L1 therapy
Immune checkpoint inhibitors (ICIs), specifically targeting the programmed cell death protein-1 or its ligand (PD-1/PD-L1), have been extensively used in the treatment of a spectrum of malignancies, although t...
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Article
Open AccessEfficacy of ganglion impar block combined with pudendal nerve pulsed radiofrequency for pudendal neuralgia management—a randomized clinical trial
Pudendal neuralgia is a chronic and debilitating condition. Its prevalence ranges from 5 to 26%. Currently, therapeutic approaches to treat pudendal neuralgia include patient education, medication management, ...
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Article
Open AccessThe landscape of transcriptional profiles in human oocytes with different chromatin configurations
With increasingly used assisted reproductive technology (ART), the acquisition of high-quality oocytes and early embryos has become the focus of much attention. Studies in mice have found that the transition o...
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Article
Open AccessHelicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3
Helicobacter pylori (H. pylori) is the predominant etiological agent of gastritis and disrupts the integrity of the gastric mucosal barrier through various pathogenic mechanisms. After H. pylori invades the gastr...
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Article
Open AccessApplication of deep learning in isolated tooth identification
Teeth identification has a pivotal role in the dental curriculum and provides one of the important foundations of clinical practice. Accurately identifying teeth is a vital aspect of dental education and clini...
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Article
Open AccessA search for R-parity-violating supersymmetry in final states containing many jets in pp collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
A search for R-parity-violating supersymmetry in final states with high jet multiplicity is presented. The search uses 140 fb−1 of proton-proton collision data at
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Article
Open AccessDevelopment of Aptamer-DNAzyme based metal-nucleic acid frameworks for gastric cancer therapy
The metal-nucleic acid nanocomposites, first termed metal-nucleic acid frameworks (MNFs) in this work, show extraordinary potential as functional nanomaterials. However, thus far, realized MNFs face limitation...
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Article
Open AccessScreening and diagnosis of cardiovascular disease using artificial intelligence-enabled cardiac magnetic resonance imaging
Cardiac magnetic resonance imaging (CMR) is the gold standard for cardiac function assessment and plays a crucial role in diagnosing cardiovascular disease (CVD). However, its widespread application has been l...
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Article
Open AccessCastration alters the ileum microbiota of Holstein bulls and promotes beef flavor compounds
In the beef industry, bull calves are usually castrated to improve flavor and meat quality; however, this can reduce their growth and slaughter performance. The gut microbiota is known to exert a significant i...
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Article
Open AccessPredictive Value of 5-Methoxytryptophan on Long-Term Clinical Outcome after PCI in Patients with Acute Myocardial Infarction-a Prospective Cohort Study
In recent years, 5-Methoxytryptophan (5-MTP) has been identified as an endothelial factor with vaso-protective and anti-inflammatory properties.
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Article
Open AccessThe activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial
Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) protein significantly improve survival in patients with advanced non-small-cell lung cancer (NSCLC), but its impact on early-stage grou...
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Article
Open AccessOPN silencing reduces hypoxic pulmonary hypertension via PI3K-AKT-induced protective autophagy
Hypoxic pulmonary hypertension (HPH) is a pulmonary vascular disease primarily characterized by progressive pulmonary vascular remodeling in a hypoxic environment, posing a significant clinical challenge. Leve...
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Article
Open AccessInfection with SARS-CoV-2 can cause pancreatic impairment
Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of diabetes. Herein, we retrospectively analyzed pancreatic lesions...
