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Article
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
Bruton’s tyrosine kinase (BTK) has emerged as a therapeutic target for B-cell malignancies, which is substantiated by the efficacy of various irreversible or reversible BTK inhibitors. However, on-target BTK m...
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Article
Controlling hydrogenation of C=C and C=O bonds in cinnamaldehyde using Pt1/Ni and Pt1/Co single-atom alloy catalysts
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Article
Frontostriatal circuit dysfunction leads to cognitive inflexibility in neuroligin-3 R451C knockin mice
Cognitive and behavioral rigidity are observed in various psychiatric diseases, including in autism spectrum disorder (ASD). However, the underlying mechanism remains to be elucidated. In this study, we found ...
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Article
Efficient Production of Melanin by Aureobasidium Melanogenum Using a Simplified Medium and pH-Controlled Fermentation Strategy with the Cell Morphology Analysis
Natural melanin is a biopolymer with wide application prospects in medicine, food, cosmetics, environmental protection, agriculture, and so on. Microbial fermentation is an important and effective way to produ...
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Article
The Gene Expression Profiles Associated with Maternal Nicotine Exposure in the Liver of Offspring Mice
This study aims to investigate the effect of maternal nicotine exposure on the gene expression profiles in the liver of offspring mice. Pregnant mice were subcutaneously injected with either saline vehicle or ...
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Article
Risk stratification of hemodynamically significant patent ductus arteriosus by clinical and genetic factors
Hemodynamically significant patent ductus arteriosus (hsPDA) is associated with increased comorbidities in neonates. Early evaluation of hsPDA risk is critical to implement individualized intervention. The aim...
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Article
Three-dimensional architecture using hollow Cu/C nanofiber interpenetrated with MXenes for high-rate lithium-ion batteries
Improving the electron/ion transport ability and alleviating expansion during charging/discharging processes are vital for lithium-ion batteries (LIBs). In this work, a three-dimensional anode was fabricated u...
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Article
Associations of Dietary Anthocyanidins Intake with Bone Health in Children: A Cross-Sectional Study
Bone health and body composition share several common mechanisms like oxidative stress and inflammation. Anthocyanins have antioxidant and anti-inflammatory properties. We have reported that anthocyanins are a...
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Article
Open AccessTRIM69: a marker of metastasis and potential sensitizer to 5-Fluorouracil and PD-1 blockers in colon adenocarcinoma
Several proteins in the tripartite-motif (TRIM) family are associated with the development of colorectal cancer (CRC), but research on the role of TRIM69 was lacking. The present study examined the correlation...
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Article
Theory, Technology and Practice of Unconventional Petroleum Geology
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Article
In situ growth preparation of a new chiral covalent triazine framework core-shell microspheres used for HPLC enantioseparation
The manufacturing of chiral covalent triazine framework core-shell microspheres CC-MP CCTF@SiO2 composite is reported as stationary phase for HPLC enantioseparation. The CC-MP CCTF@SiO2 core-shell microspheres we...
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Article
Open AccessSpatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas
Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors exhibit significant heterogene...
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Article
Whirligig-Inspired Hybrid Nanogenerator for Multi-strategy Energy Harvesting
Portable energy solutions are highly desired in the era of the Internet of Things for powering various distributed microelectronic devices. At the same time, the energy crisis and catastrophic global warming a...
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Article
Secondary genomic findings in the 2020 China Neonatal Genomes Project participants
During next generation sequencing (NGS) data interpretation in critically ill newborns, there is a potential for recognizing and reporting secondary findings (SFs). Early awareness of SFs may provide clues for...
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Article
Open AccessEvaluation of GeneXpert EV assay for the rapid diagnosis of enteroviral meningitis: a systematic review and meta-analysis
GeneXpert enterovirus Assay is a PCR-based assay for Enterovirus meningitis diagnosis. However, there is currently no research about the performance of GeneXpert enterovirus assay in the diagnosis of enterovir...
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Article
Open AccessReduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder
The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...
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Article
Open AccessManagement of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care f...
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Article
Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain
Spinal cord stimulation (SCS)-induced analgesia was characterized, and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats. The analgesic effect of SCS with moder...
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Article
Open AccessNeuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression
Neuroinflammation is an important component mechanism in the development of depression. Exosomal transfer of MDD-associated microRNAs (miRNAs) from neurons to microglia might exacerbate neuronal cell inflammat...
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Article
Open AccessA positive correlation between GC content and growth temperature in prokaryotes
GC pairs are generally more stable than AT pairs; GC-rich genomes were proposed to be more adapted to high temperatures than AT-rich genomes. Previous studies consistently showed positive correlations between ...
