7 Result(s)
within
**n-Ran Lan
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessSpatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas
Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors exhibit significant heterogene...
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Article
Open AccessProfiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
Numerous substrates have been identified for Type I and II arginine methyltransferases (PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its connection to type I and II PRMT s...
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Article
Open AccessLectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a pattern recognition receptor that plays a critical role in vascular diseases and host immune response. Recently, our research discovered tha...
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Article
Open AccessHigh expression of GFAT1 predicts poor prognosis in patients with pancreatic cancer
Pancreatic cancer is one of the most lethal of all types of cancer, with the 5-year survival rate ranging only at 6–7%. The aberrant glucose metabolism is one of the hallmarks of cancer cells, and as a branch ...
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Open AccessComparison of impulsivity in non-problem, at-risk and problem gamblers
As a non-substance addiction, gambling disorder represents the model for studying the neurobiology of addiction without toxic consequences of chronic drug use. From a neuropsychological perspective, impulsivit...
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Open AccessDecreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer
Calpain-8 and calpain-9 belong to the family of calcium-dependent cysteine proteases, which are highly expressed in the stomach. However, the roles of calpain-8 and calpain-9 in gastric tumorigenesis remain li...
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Open AccessRepeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres
The Gossypium genus is used to investigate emergent consequences of polyploidy in cotton species; comparative genomic analyses reveal a complex evolutionary history including interactions among subgenomes that re...
