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Article
Open AccessGlutamate acts on acid-sensing ion channels to worsen ischaemic brain injury
Glutamate is traditionally viewed as the first messenger to activate NMDAR (N-methyl-d-aspartate receptor)-dependent cell death pathways in stroke1,2, but unsuccessful clinical trials with NMDAR antagonists impli...
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Article
Phylogenomics, divergence times and notes of orders in Basidiomycota
Basidiomycota is one of the major phyla in the fungal tree of life. The outline of Basidiomycota provides essential taxonomic information for researchers and workers in mycology. In this study, we present a ti...
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Article
Open AccessEntanglement inside a black hole before the Page time
We investigate the evolution of entanglement within an open, strongly coupled system interacting with a heat bath as its environment, in the frameworks of both the doubly holographic model and the Sachdev-Ye-K...
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Article
Solid solution strategy modulated defects engineering of (Cr1-xVx)2AlC MAX phase toward superior electromagnetic wave absorption
Defects engineering is an effective strategy for manipulating electromagnetic parameters and enhancing electromagnetic wave (EMW) absorption capacity. However, the relationship between them is not clear, espec...
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Article
Temporal Trends in Survival Outcomes for Patients with Esophageal Cancer Following Neoadjuvant Chemoradiotherapy: A 14-Year Analysis
The prognosis for patients with esophageal cancer who received neoadjuvant chemoradiotherapy (nCRT) followed by surgery has shown improvement in recent years. We sought to identify the critical factors contrib...
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Article
Multiphase evolution of a Li-pegmatite field from the Tashisayi area, Altyn Tagh, NW China: insights from a petrological, geochemical, and geochronological study
The Tashisayi Li deposit was newly discovered in the eastern part of the Tashisayi batholith, located in the Altyn Tagh region of Northwest China. A Li-rich composite pegmatite-aplite dyke (γ02) displays super...
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Article
Open AccessIn vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin
Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked with severe DCM. However, the exact association ...
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Article
Open AccessClinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review
Patients with spinal cord injury have a relatively high risk for bladder cancer and often complicated with bladder cancer in advanced stages, and the degree of aggressiveness of malignancy is high. Most of the...
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Article
Open AccessTargeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy
Retinitis pigmentosa (RP) is a genetically heterogeneous group of degenerative disorders causing progressive vision loss due to photoreceptor death. RP affects other retinal cells, including the retinal pigmen...
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Article
Ginseng-DF ameliorates intestinal mucosal barrier injury and enhances immunity in immunosuppressed mice by regulating MAPK/NF-κB signaling pathways
Dietary fiber (DF) has a good application prospect in effectively restoring the integrity of the intestinal mucosal barrier. Ginseng-DF has good physicochemical properties and physiological activity and shows ...
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Article
Prognostic and Immunotherapeutic Predictive Value of CAD Gene in Hepatocellular Carcinoma: Integrated Bioinformatics and Experimental Analysis
Hepatocellular carcinoma (HCC) is a common type of cancer that ranks first in cancer-associated death worldwide. Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) are the k...
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Article
Open AccessSRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors
The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression. However, the precise molecular mechanisms governing the nuclear import of YA...
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Article
Open AccessGenetic underpinnings explored: OPA1 deletion and complex phenotypes on chromosome 3q29
Copy number variations (CNVs) have emerged as significant contributors to the elusive genetic causality of inherited eye diseases. In this study, we describe a case with optic atrophy and a brain aneurysm, in ...
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Article
Frontiers in plant RNA research in ICAR2023: from lab to innovative agriculture
The recent growth in global warming, soil contamination, and climate instability have widely disturbed ecosystems, and will have a significant negative impact on the growth of plants that produce grains, fruit...
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Article
Open AccessInsomnia and anxiety among COVID-19 patients in China: the chain mediating effect of psychological capital and self-esteem
The outbreak of Corona Virus Disease (COVID-19) in 2019 has continued until now, posing a huge threat to the public’s physical and mental health, resulting in different degrees of mental health problems. As a ...
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Article
Open AccessA nomogram model for predicting intramyocardial hemorrhage post-PCI based on SYNTAX score and clinical features
The aim of this study is to develop a nomogram model for predicting the occurrence of intramyocardial hemorrhage (IMH) in patients with Acute Myocardial Infarction (AMI) following Percutaneous Coronary Interve...
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Article
Open AccessLocal oscillator port integrated resonator for Rydberg atom-based electric field measurement enhancement
Rydberg atom-based superheterodyne with additional local oscillator (LO) signal is a novel approach to detect electric field with high measured sensitivity. However, the LO signal is often supplied to the atom...
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Article
Open AccessEfficient numerical implementation of limit equilibrium method for stability analysis of unsaturated soil slopes using Gaussian integral
Unsaturated soil is widely distributed around the world but less considered in design due to the absence of a convenient analysis method in practice. The Morgenstern–Price (MP) method incorporating the extende...
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Article
Open AccessApplication status and optimization suggestions of tumor organoids and CAR-T cell co-culture models
Tumor organoids, especially patient-derived organoids (PDOs) exhibit marked similarities in histopathological morphology, genomic alterations, and specific marker expression profiles to those of primary tumour...
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Article
Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1
Cardiopulmonary bypass has been speculated to elicit systemic inflammation to initiate acute lung injury (ALI), including acute respiratory distress syndrome (ARDS), in patients after cardiac surgery. We previ...
