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Article
Open AccessATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells
Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, we show th...
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Article
Benefits of Hepatitis C Viral Eradication: A Real-World Nationwide Cohort Study in Taiwan
Chronic hepatitis C (CHC) increases the risk of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). This nationwide cohort study assessed the effectiveness of viral eradication of CHC.
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Article
Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice
To investigate the potential role of Tongxinluo (TXL) in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury (MIRI) in mice.
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Article
miR-141-3p attenuates RSL3-induced ferroptosis and intestinal epithelial-mesenchymal transition via directly inhabits ZEB1 in intestinal Behçet’s syndrome
The aims of this study were to investigate whether the ferroptosis is involved in intestinal Behçet’s syndrome (IBS), and to identify if miR-141-3p could attenuate RAS-selective lethal 3 (RSL3)-induced ferropt...
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Article
Clinical phenotypes of adult-onset Behçet’s syndrome: a comprehensive cross-sectional study in China
Behçet’s syndrome (BS) is a variant vasculitis that can involve multiple organs with inflammatory manifestations. This study aimed to provide a more comprehensive analysis of the clinical phenotypes and charac...
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Article
Assessing the range of blasting-induced cracks in the surrounding rock of deeply buried tunnels based on the unified strength theory
Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse, posing significant safety risks. However, previous theoretical studies on the range of ...
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Article
Experimental investigation of vibration pretreatment-microwave curing process for carbon fiber reinforced resin matrix composites
The vibration pretreatment-microwave curing process is an efficient, low energy consumption, and high-quality out-of-autoclave curing process for carbon fiber resin matrix composites. This study aims to invest...
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Article
Transcriptome-wide analysis of a superior xylan degrading isolate Penicillium oxalicum 5–18 revealed active lignocellulosic degrading genes
Lignocellulose biomass raw materials have a high value in energy conversion. Recently, there has been growing interest in using microorganisms to secret a series of enzymes for converting low-cost biomass into...
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Article
The long-term efficacy of eltrombopag in children with immune thrombocytopenia
Immune thrombocytopenia (ITP) is the most common autoimmune disorder characterized by decreased platelet counts and impaired platelet production. Eltrombopag has been demonstrated to be safe and effective for ...
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Article
Open AccessInfluence of ABC stroke score on late recurrence of paroxysmal atrial fibrillation following radiofrequency catheter ablation
In this study we investigated the impact of ABC stroke score on the recurrence of paroxysmal atrial fibrillation (PAF) following radiofrequency catheter ablation (RFCA).
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Article
GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation
Adjuvants for vaccines with characteristics of improving adaptive immunity particularly via leverage of antigen presenting cells (APCs) are currently lacking. In a previous work we obtained a new soluble 300 k...
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Article
Open AccessComprehensive meta-analysis of severe fever with thrombocytopenia syndrome virus infections in humans, vertebrate hosts and questing ticks
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis caused by the SFTS virus (SFTSV). Understanding the prevalence of SFTSV RNA in humans, vertebrate hosts and ticks is crucia...
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Article
Taxonomic identification, phenol biodegradation and soil remediation of the strain Rhodococcus sacchari sp. nov. Z13T
Phenols are highly toxic chemicals that are extensively used in industry and produce large amounts of emissions. Notably, phenols released into the soil are highly persistent, causing long-term harm to human h...
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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Article
Experimental Study on Mechanical Behavior, Fracture Characteristics, and Acoustic Emission Damage Characteristics of Sandstone Under Triaxial Multistage Stress Disturbance
The instability failure of engineering rock mass is caused by the full development of cracks under the combined action of the surrounding rock stress environment and frequent stress disturbance. The developmen...
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Article
Open AccessStructural variant landscapes reveal convergent signatures of evolution in sheep and goats
Sheep and goats have undergone domestication and improvement to produce similar phenotypes, which have been greatly impacted by structural variants (SVs). Here, we report a high-quality chromosome-level refere...
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Article
Damage Recognition of Acoustic Emission and Micro-CT Characterization of Bi-adhesive Repaired Composites Based on the Machine Learning Method
Bi-adhesive repair method is one of several repair technologies that use the adhesive bonding approach for patch-repaired composites. However, these repairs are subject to matrix-cracking and interface debondi...
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Article
Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator
The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae. Lunar samples retain valuable information from these events, via detectable long-lived “fingerprint” rad...
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Article
Laser powder bed fusion of NiTiFe shape memory alloy via pre-mixed powder: microstructural evolution, mechanical and functional properties
High-cost pre-alloyed powder is the bottleneck problem that limits the widespread application of additive-manufactured shape memory alloys. In this work, the low-cost ternary NiTiFe shape memory alloy is fabri...
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Article
Distinct element method simulation of mechanical properties of material layer of pellet belt roasting machine
The thick layer and graded feeding technology of a belt roasting machine is an effective method for improving the production efficiency and quality index of pellet production, and a reasonable design of the me...
