-
Article
Open AccessCoordinated wound responses in a regenerative animal-algal holobiont
Animal regeneration involves coordinated responses across cell types throughout the animal body. In endosymbiotic animals, whether and how symbionts react to host injury and how cellular responses are integrat...
-
Article
Open AccessCorrection: Development and validation of a Radiopathomics model based on CT scans and whole slide images for discriminating between Stage I-II and Stage III gastric cancer
-
Article
Open AccessDevelopment and validation of a Radiopathomics model based on CT scans and whole slide images for discriminating between Stage I-II and Stage III gastric cancer
This study aimed to develop and validate an artificial intelligence radiopathological model using preoperative CT scans and postoperative hematoxylin and eosin (HE) stained slides to predict the pathological s...
-
Article
Open AccessRisk assessment of imported malaria in China: a machine learning perspective
Following China’s official designation as malaria-free country by WHO, the imported malaria has emerged as a significant determinant impacting the malaria reestablishment within China. The objective of this st...
-
Article
Open AccessAn artificial protein modulator reprogramming neuronal protein functions
Reversible protein phosphorylation, regulated by protein phosphatases, fine-tunes target protein function and plays a vital role in biological processes. Dysregulation of this process leads to aberrant post-tr...
-
Article
Open AccessImmune persistence after different polio sequential immunization schedules in Chinese infants
Trivalent oral poliovirus vaccine (tOPV) has been withdrawn and instead an inactivated poliovirus vaccine (IPV) and bivalent type 1 and type 3 OPV (bOPV) sequential immunization schedule has been implemented s...
-
Article
Open AccessBuilding Feedback-Regulation System Through Atomic Design for Highly Active SO2 Sensing
Feedback-regulation system is established between single Pt sites and MoS2 supports
The Pt1-MoS2-def can expand the electron...
-
Article
Open AccessHydrogen bond unlocking-driven pore structure control for shifting multi-component gas separation function
Purification of ethylene (C2H4) as the most extensive and output chemical, from complex multi-components is of great significance but highly challenging. Herein we demonstrate that precise pore structure tuning b...
-
Article
Open AccessTemporal dendritic heterogeneity incorporated with spiking neural networks for learning multi-timescale dynamics
It is widely believed the brain-inspired spiking neural networks have the capability of processing temporal information owing to their dynamic attributes. However, how to understand what kind of mechanisms con...
-
Article
Open AccessThe ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer
Neuroendocrine prostate cancer is a rapidly progressive and lethal disease characterized by early visceral metastasis, poor prognosis, and limited treatment options. Uncovering the oncogenic mechanisms could l...
-
Article
Open AccessQuantum storage of entangled photons at telecom wavelengths in a crystal
Quantum storage and distribution of entanglement are the key ingredients for realizing a global quantum internet. Compatible with existing fiber networks, telecom-wavelength entangled photons and corresponding...
-
Article
Open AccessMetagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease
The gut microbiota plays a crucial role in regulating host metabolism and producing uremic toxins in patients with end-stage renal disease (ESRD). Our objective is to advance toward a holistic understanding of...
-
Article
Open AccessParticle flow simulation of Brazilian splitting failure characteristics of layered shale
Shale reservoir is the research hotspot in the development of unconventional oil and gas resources. The properties of bedding plane have an important influence on the mechanical behavior of shale. According to...
-
Article
Open AccessRevealing the role of interfacial water and key intermediates at ruthenium surfaces in the alkaline hydrogen evolution reaction
Ruthenium exhibits comparable or even better alkaline hydrogen evolution reaction activity than platinum, however, the mechanistic aspects are yet to be settled, which are elucidated by combining in situ Raman...
-
Article
Open AccessCarcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling
Carcinoma-associated fibroblasts (CAFs) are the main cellular components of the tumor microenvironment and promote cancer progression by modifying the extracellular matrix (ECM). The tumor-associated ECM is ch...
-
Article
Open AccessContinuous venovenous hemodiafiltration versus standard medical therapy for the prevention of rhabdomyolysis-induced acute kidney injury: a retrospective cohort study
To determine whether continuous venovenous hemodiafiltration (CVVHDF) plus standard medical therapy (SMT) vs. SMT alone prevents rhabdomyolysis (RM)-induced acute kidney injury (AKI) and analyze the related he...
-
Article
Open AccessA ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells
Internalization of complement membrane attack complexes (MACs) assembles NLRP3 inflammasomes in endothelial cells (EC) and promotes IL-β-mediated tissue inflammation. Informed by proteomics analyses of FACS-so...
-
Article
Open AccessBiological evaluation of novel gemcitabine analog in patient-derived xenograft models of pancreatic cancer
Gemcitabine (Gem) has been a standard first-line drug for pancreatic cancer (PCa) treatment; however, Gem's rapid metabolism and systemic instability (short half-life) limit its clinical outcome. The objective...
-
Article
Open AccessAdhesive cryogel particles for bridging confined and irregular tissue defects
Reconstruction of damaged tissues requires both surface hemostasis and tissue bridging. Tissues with damage resulting from physical trauma or surgical treatments may have arbitrary surface topographies, making...
-
Article
Open AccessEvaluation of the immunization effectiveness of bOPV booster immunization and IPV revaccination
To provide a basis for further optimization of the polio sequential immunization schedule, this study evaluated the effectiveness of booster immunization with one dose of bivalent oral poliovirus vaccine (bOPV...
