15 Result(s)
within
**n-Bo Xue
Cell Biology
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Chapter
Technologies for Visualization and Tracking of Extracellular Vesicles
Extracellular vesicles (EVs) are intercellular communicators that can deliver important biological molecules to recipient cells to participate in the regulation of pathophysiological processes. In recent years...
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Open AccessSafety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants: a randomized phase 2 trial
An ongoing randomized, double-blind, controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate, named NVSI-06-09, as a booster dose in subj...
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IL-18BP Alleviates Anxiety-Like Behavior Induced by Traumatic Stress via Inhibition of the IL-18R-NLRP3 Signaling Pathway in a Mouse Model of Hemorrhagic Shock and Resuscitation
Psychological distress and posttraumatic stress, including anxiety, severely influence life quality. Previously, we reported that interleukin-18 (IL-18) was involved in pyroptosis-induced emotional changes in ...
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Open AccessDesign of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2
The continuous emergence of SARS-CoV-2 variants highlights the need of develo** vaccines with broad protection. Here, according to the immune-escape capability and evolutionary convergence, the representativ...
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Open AccessProtein arginine methyltransferase 1 regulates cell proliferation and differentiation in adult mouse adult intestine
Adult stem cells play an essential role in adult organ physiology and tissue repair and regeneration. While much has been learnt about the property and function of various adult stem cells, the mechanisms of t...
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Open AccessHistone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1
TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still r...
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Open AccessHigh glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy
Mitochondrial dysfunction and impaired Ca2+ handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level of ph...
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Effects of Docosahexaenoic Acid and Its Peroxidation Product on Amyloid-β Peptide-Stimulated Microglia
Growing evidence suggests that docosahexaenoic acid (DHA) exerts neuroprotective effects, although the mechanism(s) underlying these beneficial effects are not fully understood. Here we demonstrate that DHA, b...
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Open AccessFunction and dysfunction of plasma cells in intestine
As the main player in humoral immunity, antibodies play indispensable roles in the body’s immune system. Plasma cells (PCs), as antibody factories, are important contributors to humoral immunity. PCs, recogniz...
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Open AccessVCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity
Mesenchymal stem cells (MSCs) represent a heterogeneous cell population that is promising for regenerative medicine. The present study was designed to assess whether VCAM-1 can be used as a marker of MSC subpo...
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Sprout vacuum-infiltration: a simple and efficient agroinoculation method for virus-induced gene silencing in diverse solanaceous species
Virus-induced gene silencing (VIGS) is a robust technique for identifying the functions of plant genes. Tobacco rattle virus (TRV)-mediated VIGS has been commonly used in many plants. In order to overcome the ...
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Mechanisms for Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of the Blood–Tumor Barrier
Endothelial monocyte-activating polypeptide-II (EMAP-II) increases blood–tumor barrier (BTB) permeability by inducing alterations in the tight junction (TJ) complex between brain endothelial cells. In the pres...
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Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy
The small guanosine triphosphatase RhoA has recently been implicated in the pathogenesis of epilepsy in animals. In this study, we investigated the expression of RhoA in human epilepsy. Brain tissue samples fr...
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The formation of Ca2+ gradients at the cleavage furrows during cytokinesis of Zebrafish embryos
In dividing embryos, a localized elevation in intracellular Ca2+ ([Ca2+]i) at the cleavage furrow has been shown to be essential for cytokinesis. However, the underlying mechanisms for generating and maintaining ...
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Predicting intrinsic disorder in proteins: an overview
The discovery of intrinsically disordered proteins (IDP) (i.e., biologically active proteins that do not possess stable secondary and/or tertiary structures) came as an unexpected surprise, as the existence of...
