8 Result(s)
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**n-Bo Xue
English
Cell Biology
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Article
Open AccessSafety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants: a randomized phase 2 trial
An ongoing randomized, double-blind, controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate, named NVSI-06-09, as a booster dose in subj...
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Article
Open AccessDesign of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2
The continuous emergence of SARS-CoV-2 variants highlights the need of develo** vaccines with broad protection. Here, according to the immune-escape capability and evolutionary convergence, the representativ...
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Open AccessProtein arginine methyltransferase 1 regulates cell proliferation and differentiation in adult mouse adult intestine
Adult stem cells play an essential role in adult organ physiology and tissue repair and regeneration. While much has been learnt about the property and function of various adult stem cells, the mechanisms of t...
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Open AccessHistone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1
TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still r...
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Open AccessHigh glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy
Mitochondrial dysfunction and impaired Ca2+ handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level of ph...
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Open AccessFunction and dysfunction of plasma cells in intestine
As the main player in humoral immunity, antibodies play indispensable roles in the body’s immune system. Plasma cells (PCs), as antibody factories, are important contributors to humoral immunity. PCs, recogniz...
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Open AccessVCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity
Mesenchymal stem cells (MSCs) represent a heterogeneous cell population that is promising for regenerative medicine. The present study was designed to assess whether VCAM-1 can be used as a marker of MSC subpo...
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Predicting intrinsic disorder in proteins: an overview
The discovery of intrinsically disordered proteins (IDP) (i.e., biologically active proteins that do not possess stable secondary and/or tertiary structures) came as an unexpected surprise, as the existence of...
