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Article
Open AccessCoordinated wound responses in a regenerative animal-algal holobiont
Animal regeneration involves coordinated responses across cell types throughout the animal body. In endosymbiotic animals, whether and how symbionts react to host injury and how cellular responses are integrat...
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Article
Open AccessAn artificial protein modulator reprogramming neuronal protein functions
Reversible protein phosphorylation, regulated by protein phosphatases, fine-tunes target protein function and plays a vital role in biological processes. Dysregulation of this process leads to aberrant post-tr...
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Article
Open AccessHydrogen bond unlocking-driven pore structure control for shifting multi-component gas separation function
Purification of ethylene (C2H4) as the most extensive and output chemical, from complex multi-components is of great significance but highly challenging. Herein we demonstrate that precise pore structure tuning b...
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Article
Open AccessTemporal dendritic heterogeneity incorporated with spiking neural networks for learning multi-timescale dynamics
It is widely believed the brain-inspired spiking neural networks have the capability of processing temporal information owing to their dynamic attributes. However, how to understand what kind of mechanisms con...
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Article
Open AccessThe ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer
Neuroendocrine prostate cancer is a rapidly progressive and lethal disease characterized by early visceral metastasis, poor prognosis, and limited treatment options. Uncovering the oncogenic mechanisms could l...
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Article
Open AccessQuantum storage of entangled photons at telecom wavelengths in a crystal
Quantum storage and distribution of entanglement are the key ingredients for realizing a global quantum internet. Compatible with existing fiber networks, telecom-wavelength entangled photons and corresponding...
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Article
Open AccessRevealing the role of interfacial water and key intermediates at ruthenium surfaces in the alkaline hydrogen evolution reaction
Ruthenium exhibits comparable or even better alkaline hydrogen evolution reaction activity than platinum, however, the mechanistic aspects are yet to be settled, which are elucidated by combining in situ Raman...
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Article
Open AccessA ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells
Internalization of complement membrane attack complexes (MACs) assembles NLRP3 inflammasomes in endothelial cells (EC) and promotes IL-β-mediated tissue inflammation. Informed by proteomics analyses of FACS-so...
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Article
Open AccessEstablishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection
Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively modifies proteoglycans (PGs) of ...
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Article
Open AccessUnraveling sulfur chemistry in interstellar carbon oxide ices
Formyl radical (HCO•) and hydroxycarbonyl radical (HOCO•) are versatile building blocks in the formation of biorelevant complex organic molecules (COMs) in interstellar medium. Understanding the chemical pathw...
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Article
Open AccessA spin-crossover framework endowed with pore-adjustable behavior by slow structural dynamics
Host-guest interactions play critical roles in achieving switchable structures and functionalities in porous materials, but design and control remain challenging. Here, we report a two-dimensional porous magne...
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Article
Open AccessNeural network-based prediction of the secret-key rate of quantum key distribution
Numerical methods are widely used to calculate the secure key rate of many quantum key distribution protocols in practice, but they consume many computing resources and are too time-consuming. In this work, we...
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Article
Open AccessGiant single-crystal-to-single-crystal transformations associated with chiral interconversion induced by elimination of chelating ligands
Numerous single crystals that exhibit single-crystal-to-single-crystal (SCSC) transformations have been reported, and some of them show great promise for application to advanced adsorption materials, magnetic ...
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Open AccessAuthor Correction: BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit
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Article
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2
An outbreak of coronavirus disease 2019 (COVID-19)1–3, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4, has spread globally. Countermeasures are needed to treat and prevent further dissemi...
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Article
Open AccessIntegrated omics in Drosophila uncover a circadian kinome
Most organisms on the earth exhibit circadian rhythms in behavior and physiology, which are driven by endogenous clocks. Phosphorylation plays a central role in timing the clock, but how this contributes to ov...
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Article
Open AccessEnvironmental remodeling of human gut microbiota and antibiotic resistome in livestock farms
Anthropogenic environments have been implicated in enrichment and exchange of antibiotic resistance genes and bacteria. Here we study the impact of confined and controlled swine farm environments on temporal c...
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Article
Open AccessReconstruction of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in Cerebral Infarction
Functioning as miRNA sponges, long non-coding RNA (lncRNA) exert its pharmacological action via regulating expression of protein-coding genes. However, the lncRNA-mediated ceRNA in cerebral Infarction (CI) rem...
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Article
Open AccessStructural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction
Hepatitis B virus (HBV) X protein, HBx, interacts with anti-apoptotic Bcl-2 and Bcl-xL proteins through its BH3-like motif to promote HBV replication and cytotoxicity. Here we report the crystal structure of H...
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Article
A vitamin-C-derived DNA modification catalysed by an algal TET homologue
Methylation of cytosine to 5-methylcytosine (5mC) is a prevalent DNA modification found in many organisms. Sequential oxidation of 5mC by ten-eleven translocation (TET) dioxygenases results in a cascade of add...