26 Result(s)
within
**n-Bo Xue
Life Sciences
-
Article
A pollen selection system links self and interspecific incompatibility in the Brassicaceae
Self-incompatibility and recurrent transitions to self-compatibility have shaped the extant mating systems underlying the nonrandom mating critical for speciation in angiosperms. Linkage between self-incompati...
-
Article
Antimicrobial Peptides Targeting Streptococcus mutans: Current Research on Design, Screening and Efficacy
Antimicrobial peptides (AMPs) are small-molecule peptides that play a vital role in the nonspecific immune defense system of organisms. They mainly kill microorganisms by physically destroying the cell membran...
-
Article
Open AccessMetagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease
The gut microbiota plays a crucial role in regulating host metabolism and producing uremic toxins in patients with end-stage renal disease (ESRD). Our objective is to advance toward a holistic understanding of...
-
Article
Open AccessIntegrated analysis of microRNAs, circular RNAs, long non-coding RNAs, and mRNAs revealed competing endogenous RNA networks involved in brown adipose tissue whitening in rabbits
The brown adipose tissue (BAT) is a target for treating obesity. BAT losses thermogenic capacity and gains a “white adipose tissue-like” phenotype (“BAT whitening”) under thermoneutral environments, which is a...
-
Article
Open AccessLilac (Syringa oblata) genome provides insights into its evolution and molecular mechanism of petal color change
Color change during flower opening is common; however, little is understood on the biochemical and molecular basis related. Lilac (Syringa oblata), a well-known woody ornamental plant with obvious petal color cha...
-
Article
Open AccessIndole alkaloids of Alstonia scholaris (L.) R. Br. alleviated nonalcoholic fatty liver disease in mice fed with high-fat diet
Alstonia scholaris (L.) R. Br (Apocynaceae) is a well-documented medicinal plant for treating respiratory diseases, liver diseases and diabetes traditionally. The current study aimed to investigate the effects of...
-
Article
Open AccessDesign of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2
The continuous emergence of SARS-CoV-2 variants highlights the need of develo** vaccines with broad protection. Here, according to the immune-escape capability and evolutionary convergence, the representativ...
-
Article
Open AccessPhase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation
Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transactivator of viral and cellular gene expression, which plays a critical role in the Epstein-Barr virus-associated diseases. It was reported that EBNA2 reg...
-
Article
Open AccessProtein arginine methyltransferase 1 regulates cell proliferation and differentiation in adult mouse adult intestine
Adult stem cells play an essential role in adult organ physiology and tissue repair and regeneration. While much has been learnt about the property and function of various adult stem cells, the mechanisms of t...
-
Article
Open AccessHistone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1
TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still r...
-
Article
Open AccessHigh glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy
Mitochondrial dysfunction and impaired Ca2+ handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level of ph...
-
Article
Germline genomes have a dominant-heritable contribution to cancer immune evasion and immunotherapy response
Immune evasion is a fundamental hallmark for cancer. At the early stages of tumor development, immune evasion strategies must be implemented by tumors to prevent attacks from the host immune systems. Blocking ...
-
Article
Structural mechanism of the active bicarbonate transporter from cyanobacteria
Bicarbonate transporters play essential roles in pH homeostasis in mammals and photosynthesis in aquatic photoautotrophs. A number of bicarbonate transporters have been characterized, among which is BicA—a low...
-
Article
Open AccessFunction and dysfunction of plasma cells in intestine
As the main player in humoral immunity, antibodies play indispensable roles in the body’s immune system. Plasma cells (PCs), as antibody factories, are important contributors to humoral immunity. PCs, recogniz...
-
Article
Open AccessProbe-based association analysis identifies several deletions associated with average daily gain in beef cattle
Average daily gain (ADG) is an important trait that contributes to the production efficiency and economic benefits in the beef cattle industry. The molecular mechanisms of ADG have not yet been fully explored ...
-
Article
Open AccessFRET biosensor allows spatio-temporal observation of shear stress-induced polar RhoGDIα activation
Rho GDP-dissociation inhibitor α (RhoGDIα) is a known negative regulator of the Rho family that shuts off GDP/GTP cycling and cytoplasm/membrane translocation to regulate cell migration. However, to our knowle...
-
Article
Open AccessGenome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP array
Fatty acid composition of muscle is an important trait contributing to meat quality. Recently, genome-wide association study (GWAS) has been extensively used to explore the molecular mechanism underlying impor...
-
Article
Open AccessVCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity
Mesenchymal stem cells (MSCs) represent a heterogeneous cell population that is promising for regenerative medicine. The present study was designed to assess whether VCAM-1 can be used as a marker of MSC subpo...
-
Article
Adjusting migration schedules at stop** sites: time strategy of a long-distance migratory shorebird during northward migration
Selection of timing to match optimal environments is crucial for migrants that breed at high latitudes where there is a narrow time window suitable for breeding. However, birds generally depart from non-breedi...
-
Article
Integrated butanol recovery for an advanced biofuel: current state and prospects
Butanol has recently gained increasing interest due to escalating prices in petroleum fuels and concerns on the energy crisis. However, the butanol production cost with conventional acetone–butanol–ethanol fer...
