33 Result(s)

Article

Correction: Promotion of osteogenesis in BMSC under hypoxia by ATF4 via the PERK–eIF2α signaling pathway

Yuan Feng, Zhiqi Han, Weidong Jiang… in In Vitro Cellular & Developmental Biology … (2024)

Article

Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation

Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that controls differentiation remains elusive. Here, we show that t...

Huan Liu, Lu Sun, Hongfei Zhao, Zihan Zhao, Shiyue Zhang… in Cell Death & Differentiation (2024)

Article

The OGT–c-Myc–PDK2 axis rewires the TCA cycle and promotes colorectal tumor growth

Deregulated glucose metabolism termed the “Warburg effect” is a fundamental feature of cancers, including the colorectal cancer. This is typically characterized with an increased rate of glycolysis, and a conc...

Huijuan Wang, Jie Sun, Haofan Sun, Yifei Wang, Bingyi Lin… in Cell Death & Differentiation (2024)

Article

Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment

Osteoarthritis affects 15% of people over 65 years of age. It is characterized by articular cartilage degradation and inflammation, leading to joint pain and disability. Osteoarthritis is incurable and the pat...

Hongshang Chu, Shaoyang Zhang, Zhenlin Zhang, Hua Yue… in npj Regenerative Medicine (2024)

Article

Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation

High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid (DCA) caused by HFD plays significant roles in e...

Dan Li, Jiefei Zhou, Lingyu Wang, Zizhen Gong, Huijuan Le, Ye Huang… in Cell & Bioscience (2023)

Article

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging

Ultraviolet A (UVA) irradiation can lead to skin damage and premature skin aging known as photoaging. This work found that UVA irradiation caused an imbalance between dermal matrix synthesis and degradation th...

Yinan Li, **u Huang, **g **, Haohao Zhang, Kai Yang, **gxia Han… in Cell & Bioscience (2023)

Article

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to ...

Bang Li, Hui Zhao, Zhuchi Tu, Weili Yang, Rui Han, Lu Wang, **aopeng Luo… in Cell Discovery (2023)

Article

Correction to: M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway

Hang Yin, Lin Chen, Shiqi Piao, Yiru Wang, Zhange Li… in Cell Death & Differentiation (2023)

Article

Aurora kinase a promotes the progression of papillary thyroid carcinoma by activating the mTORC2-AKT signalling pathway

Treatment failure is the main cause of death from papillary thyroid carcinoma (PTC). It is urgent to look for new intervention targets and to develop new therapies for treating PTC. Aurora-A kinase (AURKA) fun...

Zewei Zhao, Huijuan Wang, Ning Kang, Zhongyu Wang, … in Cell & Bioscience (2022)

Article

AXDND1, a novel testis-enriched gene, is required for spermiogenesis and male fertility

Spermiogenesis is a complex process depending on the sophisticated coordination of a myriad of testis-enriched gene regulations. The regulatory pathways that coordinate this process are not well understood, an...

Qian Ma, Congcong Cao, Changshui Zhuang, **aomin Luo, **aofeng Li… in Cell Death Discovery (2021)

Article

NLRP3 associated with chronic kidney disease progression after ischemia/reperfusion-induced acute kidney injury

Nod-like receptor protein 3 (NLRP3), as an inflammatory regulator, has been implicated in acute kidney injury (AKI). Failed recovery after AKI can lead to chronic kidney disease (CKD). However, the role of NLR...

Zhihuang Zheng, Kexin Xu, Chuanlei Li, Chenyang Qi, Yili Fang… in Cell Death Discovery (2021)

Article

The impact of recipient age on the effects of umbilical cord mesenchymal stem cells on HBV-related acute-on-chronic liver failure and liver cirrhosis

The results of a previous study verified that umbilical cord mesenchymal stem cells (UCMSCs) have good therapeutic effects for the treatment of HBV-related acute-on-chronic liver failure (ACLF) and liver cirrh...

Ka Zhang, Haixia Sun, Huijuan Cao, Yifan Jia, **n Shu… in Stem Cell Research & Therapy (2021)

Article

Effects of low lead exposure on sperm quality and sperm DNA methylation in adult men

Lead (Pb) exposure is a risk factor for male infertility, but the epigenetic changes in sperm DNAattributable to lead exposure is poorly defined.

Tiancheng Zhang, Yan Fei Ru, Bin Wu, Haiyan Dong, Liang Chen… in Cell & Bioscience (2021)

Article

MicroRNA-205 mediates endothelial progenitor functions in distraction osteogenesis by targeting the transcription regulator NOTCH2

Distraction osteogenesis (DO) is a highly efficacious form of reconstructive bone regeneration, but its clinical utility is limited by the prolonged period required for bone consolidation to occur. Understandi...

Weidong Jiang, Peiqi Zhu, Tao Zhang, Fengchun Liao… in Stem Cell Research & Therapy (2021)

Article

Single-cell transcriptome analysis of uncultured human umbilical cord mesenchymal stem cells

Umbilical cord mesenchymal stem cells (UC-MSCs) have certain advantages over other MSCs and about 300 clinical trials have been registered using UC-MSCs to treat diseases such as osteoarthritis, autoimmune dis...

Shaoyang Zhang, **g Yi Wang, Baojie Li, Feng Yin… in Stem Cell Research & Therapy (2021)