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Article
Open AccessComprehensive investigation of malignant epithelial cell-related genes in clear cell renal cell carcinoma: development of a prognostic signature and exploration of tumor microenvironment interactions
Clear cell renal cell carcinoma (ccRCC) is a prevalent malignancy with complex heterogeneity within epithelial cells, which plays a crucial role in tumor progression and immune regulation. Yet, the clinical im...
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Article
Open AccessNocturnal urination is associated with the presence of higher ventilatory chemosensitivity in patients with obstructive sleep apnea
Chemosensitivity is an essential part of the pathophysiological mechanisms of obstructive sleep apnea (OSA). This study aims to use the rebreathing method to assess hypercapnic ventilatory response (HCVR) and ...
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Article
Open AccessSuccessive stamen movement in Saxifraga candelabrum is responsive to weather and pollinator visits
Successive stamen movement is a complex plant behavior involving successive uplift of stamens and pollen release, which plays a role in reducing sexual interference, increasing pollen deposition and promoting ...
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Article
Open Accessβ cell function and insulin resistance have gender-specific correlations with carotid intima-media thickness in type 2 diabetes
The relationships between carotid intima-media thickness (C-IMT) and β cell function and insulin resistance in patients with type 2 diabetes (T2D) have not been fully elucidated. This study is to investigate w...
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Article
Open AccessImproving access to primary health care through financial innovation in rural China: a quasi-experimental synthetic difference-in-differences approach
Inadequate financing constrains primary healthcare (PHC) capacity in many low- and middle-income countries, particularly in rural areas. This study evaluates an innovative PHC financing reform in rural China t...
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Article
Open AccessFinancial reporting for cryptocurrency
This study compares and contrasts US and international accounting and financial reporting practices for cryptocurrency. We analyze the financial statements of 40 global companies that have exposure to cryptocu...
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Article
Open AccessIncorporating the inflammation-related parameters enhances the performance of the nomogram for predicting local control in lung cancer patients treated with stereotactic body radiation therapy
The study aims to investigate whether including the inflammation-related parameters would enhance the accuracy of a nomogram for local control (LC) prediction in lung cancer patients undergoing stereotactic bo...
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Article
Open AccessOpen surgery with a lateral neck approach in cases of foreign body impaction that penetrating the neck through the esophagus: a single-center experience
Because the cases are quite scarce, we aimed to review cases of foreign body impaction penetrating the neck through the esophagus to analyze the characteristics of these cases. The open surgery skills of the s...
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Article
Open AccessParkinson’s disease with anxiety: clinical characteristics and their correlation with oxidative stress, inflammation, and pathological proteins
This study was performed to explore the differences in the clinical characteristics and oxidative stress indicators, inflammatory factors, and pathological proteins in serum between Parkinson’s disease (PD) wi...
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Article
Open AccessIntegrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and characterized by desmoplastic matrix. The heterogeneity and crosstalk of tumor microenvironment remain incompletely understood.
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Article
Open AccessEffectiveness and safety in non-valvular atrial fibrillation patients switching from warfarin to direct oral anticoagulants in US healthcare claims
There is a paucity of real-world studies examining the risks of stroke/systemic embolism (SE) and major bleeding (MB) among non-valvular atrial fibrillation (NVAF) patients switching from warfarin to a direct ...
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Article
Open AccessPRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
CDK4/6 inhibitors (CDK4/6i) have improved survival of patients with estrogen receptor-positive (ER+) breast cancer. However, patients treated with CDK4/6i eventually develop drug resistance and progress. RB1 loss...
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Article
Open AccessIdentification of the prognostic value of LACTB2 and its correlation with immune infiltrates in ovarian cancer by integrated bioinformatics analyses
Ovarian cancer (OC) is one of the most common reproductive tumors in women, whereas current treatment options are limited. β-lactamase-like-protein 2 (LACTB2) has been observed to be associated with various ca...
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Article
Open AccessEcosystem service valuation and multi-scenario simulation in the Ebinur Lake Basin using a coupled GMOP-PLUS model
The Ebinur Lake Basin is an ecologically sensitive area in an arid region. Investigating its land use and land cover (LULC) change and assessing and predicting its ecosystem service value (ESV) are of great im...
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Article
Open AccessComprehensive machine learning-based preoperative blood features predict the prognosis for ovarian cancer
Significant advancements in improving ovarian cancer (OC) outcomes have been limited over the past decade. To predict prognosis and improve outcomes of OC, we plan to develop and validate a robust prognosis si...
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Article
Open AccessHsa_circ_0005397 promotes hepatocellular carcinoma progression through EIF4A3
The purpose of this study was to explore the expression and potential mechanism of hsa_circ_0005397 in hepatocellular carcinoma progression.
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Article
Open AccessCombined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults
Vitamin D deficiency and systemic inflammation share common pathological mechanisms in muscle loss, cardio-pulmonary function decline, and abnormal metabolism, which are linked to chronic conditions, senescenc...
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Article
Open AccesshUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model
Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disease of the central nervous system that affects motor function and causes relapsing disability. Human umbilical cord-derived mesenchymal stem c...
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Article
Open AccessThe examination of the relationship between learning motivation and learning effectiveness: a mediation model of learning engagement
In the past decade, China has entered the process of universalization of higher education, however, with the popularization of higher education, the issue of education quality has become more important than ev...
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Article
Open AccessEarly bone loss in patients with obstructive sleep apnea: a cross-sectional study
Obstructive sleep apnea (OSA) and osteoporosis are both prevalent diseases with shared pathophysiological mechanisms and risk factors. However, the association between the two diseases is seldom studied. This ...
