38 Result(s)
within
**mei Luo
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessPRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
CDK4/6 inhibitors (CDK4/6i) have improved survival of patients with estrogen receptor-positive (ER+) breast cancer. However, patients treated with CDK4/6i eventually develop drug resistance and progress. RB1 loss...
-
Article
Open AccessEcosystem service valuation and multi-scenario simulation in the Ebinur Lake Basin using a coupled GMOP-PLUS model
The Ebinur Lake Basin is an ecologically sensitive area in an arid region. Investigating its land use and land cover (LULC) change and assessing and predicting its ecosystem service value (ESV) are of great im...
-
Article
Open AccessThe examination of the relationship between learning motivation and learning effectiveness: a mediation model of learning engagement
In the past decade, China has entered the process of universalization of higher education, however, with the popularization of higher education, the issue of education quality has become more important than ev...
-
Article
Open AccessThe relationship between demographic factors and syncopal symptom in pediatric vasovagal syncope
This research proposed to retrospectively analyze 20 years of clinical data and investigate the relationship between demographic factors and syncopal symptom in pediatric vasovagal syncope. A total of 2513 chi...
-
Article
Open AccessExpanding PROTACtable genome universe of E3 ligases
Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD) molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new opportunities to engage targets that rem...
-
Article
Open AccessDevelopment and application of a new biological nano-selenium fermentation broth based on Bacillus subtilis SE201412
In order to improve the functionality and additional value of agricultural products, this study develo** nano-selenium fermentation broth and established a new application strategy of bio-nano-selenium by sc...
-
Article
Open AccessStructures of the CcmABCD heme release complex at multiple states
Cytochromes c use heme as a cofactor to carry electrons in respiration and photosynthesis. The cytochrome c maturation system I, consisting of eight membrane proteins (CcmABCDEFGH), results in the attachment of h...
-
Article
Open AccessMulti-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy
Autophagy is a major contributor to anti-cancer therapy resistance. Many efforts have been made to understand and overcome autophagy-mediated therapy resistance, but these efforts have been unsuccessful in cli...
-
Article
Open AccessKetamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway
To investigate the effects of ketamine on glucose uptake and glucose transporter (GLUT) expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-y...
-
Article
Open AccessA bagging dynamic deep learning network for diagnosing COVID-19
COVID-19 is a serious ongoing worldwide pandemic. Using X-ray chest radiography images for automatically diagnosing COVID-19 is an effective and convenient means of providing diagnostic assistance to clinician...
-
Article
Open AccessS-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-...
-
Article
Open AccessAuthor Correction: An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21726-y
-
Article
Open AccessAn all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine
Epigenetic modifications of DNA play important roles in many biological processes. Identifying readers of these epigenetic marks is a critical step towards understanding the underlying mechanisms. Here, we pre...
-
Article
Open AccessCurcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway
Pseudorabies virus (PRV) infection can elicit nervous system disorders. Curcumin has been reported to have neuroprotective effects. However, whether curcumin can protect neurons against PRV infection and the u...
-
Article
Open AccessA protein-independent fluorescent RNA aptamer reporter system for plant genetic engineering
Reporter systems are routinely used in plant genetic engineering and functional genomics research. Most such plant reporter systems cause accumulation of foreign proteins. Here, we demonstrate a protein-indepe...
-
Article
Open AccessLandscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows sever...
-
Article
Open AccessAtrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment
To identify the volume changes of hippocampus subfields in T2DM patients with cognitive impairment and to determine how these atrophy patterns associate with impairments in different cognitive domain.
-
Article
Open AccessMetabolomics-based study reveals the effect of lead (Pb) in the culture environment on Whitmania pigra
Whitmania pigra, called Mahuang (MH) in Chinese, has been used as a traditional Chinese medicine for many years and is susceptible to Pb exposure in aquaculture environments. To understand the impact of Pb in the...
-
Article
Open AccessEffect of sexual transmission on the West Africa Ebola outbreak in 2014: a mathematical modelling study
The outbreak of the Ebola virus has resulted in significant morbidity and mortality in the affected areas, and Ebola virus RNA has been found in the semen of the survivors after 9 months of symptom onset. Howe...
-
Article
Open AccessElectron beam melting in the fabrication of three-dimensional mesh titanium mandibular prosthesis scaffold
The study was designed to fulfill effective work-flow to fabricate three-dimensional mesh titanium scaffold for mandibular reconstruction. The 3D titanium mesh scaffold was designed based on a volunteer with w...
