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Article
Open AccessLetter to the Editor: “Continuous use of metformin in patients receiving contrast medium: What is the evidence? A systematic review and meta-analysis”
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Article
WT1 gene mutations impact post-transplant relapse in myelodysplastic syndrome with excess blasts 2 patients
Wilms tumor 1 (WT1) gene mutations are infrequent in myelodysplastic syndrome (MDS), but MDS with WT1 mutations (WT1mut) is considered high risk for acute myeloid leukemia (AML) transformation. The influence of W...
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Article
Open AccessM2-type tumor-associated macrophages upregulated PD-L1 expression in cervical cancer via the PI3K/AKT pathway
PD-1/PD-L1 inhibitors have become a promising therapy. However, the response rate is lower than 30% in patients with cervical cancer (CC), which is related to immunosuppressive components in tumor microenviron...
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Article
Open AccessOnline-to-offline combined with problem-based learning is an effective teaching modality in the standardized residency training of nephrology
The online-to-offline (O2O) teaching method is recognized as a new educational model that integrates network learning into offline classroom education, while problem-based learning (PBL) is a teaching modality...
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Article
Racial and Ethnic Disparity for Cancer Mortality in General and Single-Payer Healthcare Systems in the United States
It remains unclear what factors significantly drive racial disparity in cancer survival in the United States (US). We compared adjusted mortality outcomes in cancer patients from different racial and ethnic gr...
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Article
Open AccessNOX4-mediated astrocyte ferroptosis in Alzheimer’s disease
This study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer’s Disease (AD) using single-cell sequencing data and transcriptomes. We analyzed AD single-cell RNA...
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Article
Identification of Differentially Expressed mRNAs and lncRNAs Contributes to Elucidation of Underlying Pathogenesis and Therapeutic Strategy of Recurrent Implantation Failure
Recurrent implantation failure (RIF) is a complex and poorly understood clinical disorder characterized by failure to conceive after repeated embryo transfers. Endometrial receptivity (ER) is a prerequisite fo...
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Article
Similarities and differences between Chinese two-character words and their constituent characters in norm-feature correlations
The graphic units in Chinese are Chinese characters (characters), most of which often join with others to form words of two or more characters. High-frequency two-character words (2C-words) tend to be composed...
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Article
Prophylactic therapy using epigenetic agents for RUNX1::RUNXT1-positive high-risk AML after Allo-HSCT
Disease recurrence is the leading cause of treatment failure in patients with RUNX1::RUNXT1-positive acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Post-tran...
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Article
A bibliometric analysis of artificial intelligence in language teaching and learning (1990–2023): evolution, trends and future directions
The advancement and application of Artificial Intelligence (AI) has introduced innovative changes in language learning and teaching. In particular, the widespread utilization of various chatbots as foreign lan...
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Article
Modeling and experiment of material removal rate for cutting single-crystal silicon by electrical discharge wire sawing
Electrical discharge wire sawing (EDWS) is a hybrid processing method that can effectively remove craters and recast layers generated by discharges through the grinding action of abrasive grains. Under the sam...
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Potential of Synbiotics and Probiotics as Chemopreventive Agent
Cancer remains a global problem, with millions of new cases diagnosed yearly and countless lives lost. The financial burden of cancer therapy, along with worries about the long-term safety of existing medicine...
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Article
Open AccessImpact of health literacy, social support, and socioeconomic position on the serum uric acid level in asymptomatic hyperuricaemia patients in China: a structural equation model
Hyperuricaemia (HUA) poses a significant public health challenge on a global scale. It is mostly asymptomatic hyperuricemia (AHU) with unsatisfactory recognition and control rates. The role of health literacy ...
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Article
Open AccessStroke–heart syndrome: current progress and future outlook
Stroke can lead to cardiac complications such as arrhythmia, myocardial injury, and cardiac dysfunction, collectively termed stroke–heart syndrome (SHS). These cardiac alterations typically peak within 72 h of...
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Article
Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice
Aromatase plays an important role in ovarian development, the normal progress of the menstrual cycle, and fertility status. Elevated aromatase activity is linked to obesity. There is a bidirectional relationsh...
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Article
First report of Alternaria longipes causing kiwifruit leaf spot in China and screening of potentially fungicidal active substances
Kiwifruit, which is known for its unique flavour and high value, is extensively cultivated in the world, especially in China. In 2022, a unique case of leaf spot disease was discovered in **feng, Guizhou Provi...
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Cardiovascular adverse effects and mechanistic insights of arsenic exposure: a review
Human exposure to environmental arsenic induces cardiovascular diseases such as arrhythmias, hypertension, and arteriosclerosis. Here, we review the toxicological and cardiovascular impacts of arsenic in in ...
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Multi-resolution auto-encoder for anomaly detection of retinal imaging
Identifying unknown types of diseases is a crucial step in preceding retinal imaging classification for the sake of safety, which is known as anomaly detection of retinal imaging. However, the widely-used supe...
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Article
Open AccessPrimary Ewing’s sarcoma of the uterine cervix: a case report and review of the literature
Ewing’s sarcoma (ES) is an aggressive cancer of bone and soft tissue, most of which tend to occur in the bone. Extraosseous Ewing’s sarcoma (EES) of the cervix is extremely rare.
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Open AccessDeterminants of gastric cancer immune escape identified from non-coding immune-landscape quantitative trait loci
The landscape of non-coding mutations in cancer progression and immune evasion is largely unexplored. Here, we identify transcrptome-wide somatic and germline 3′ untranslated region (3′-UTR) variants from 375 ...
