1,250 Result(s)

Article

Promoting reactive oxygen species accumulation to overcome tyrosine kinase inhibitor resistance in cancer

In tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly compromised by drug resistance. Consequently, finding an effective so...

Wei Lin, **aojun Wang, Mingxin Diao, Yangwei Wang, Rong Zhao… in Cancer Cell International (2024)

Article

Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy

Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic disorders, including asthma, allergic rhinitis, atopic derm...

Ruiming Han, Dongdong Zhu, Jichao Sha, Boning Zhao, Peng **… in Cell & Bioscience (2024)

Article

Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression

More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of HCC distinctive due to the intricate interplay between cancer-...

Hao Peng, Meng Yang, Kun Feng, Qingpeng Lv… in Signal Transduction and Targeted Therapy (2024)

Article

Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation

**anwen Ye, Zixuan Huang, Yi Li, Mengjiao Wang, Wanyu Meng, Maojian Miao… in Cell Research (2024)

Article

WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis

Glioma is considered the most common primary malignant tumor of the central nervous system. Although traditional treatments have not achieved satisfactory outcomes, recently, targeted therapies for glioma have...

Tao Yan, Qing Jiang, Guangpu Ni, Haofeng Ma, Yun Meng… in Cancer Cell International (2024)

Article

Proteomic profiling of prostate cancer reveals molecular signatures under antiandrogen treatment

Tumorigenesis and progression of prostate cancer (PCa) are indispensably dependent on androgen receptor (AR). Antiandrogen treatment is the principal preference for patients with advanced PCa. However, the mol...

Yurun Huang, Guanglin Yang, **npeng Yao, Yue Fang, Qiliang Lin… in Clinical Proteomics (2024)

Article

VHL suppresses UBE3B-mediated breast tumor growth and metastasis

Protein homeostasis is predominantly governed through post-translational modification (PTM). UBE3B, identified as an oncoprotein, exhibits elevated protein levels in breast cancer. However, the impact of PTM o...

Shuo Wang, Huiyan Li, **ong Liu, Tingting Yin, Tingru Li… in Cell Death & Disease (2024)

Article

Muscone abrogates breast cancer progression through tumor angiogenic suppression via VEGF/PI3K/Akt/MAPK signaling pathways

Angiogenesis strongly reflects poor breast cancer outcome and an important contributor to breast cancer (BC) metastasis; therefore, anti-angiogenic intervention is a potential tool for cancer treatment. Howeve...

Danhong Wang, **aozhen Liu, Weimin Hong, Tianzheng **ao… in Cancer Cell International (2024)

Article

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity

Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to better understand the key molecules responsible for determining...

Peiran Feng, Liang Luo, Quanli Yang, Wanqing Meng, Zerong Guan… in Cell Death & Disease (2024)

Article

Lipidomic signatures in patients with early-onset and late-onset Preeclampsia

Preeclampsia is a pregnancy-specific clinical syndrome and can be subdivided into early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) according to the gestational age of delivery. Patients with ...

Yu Huang, Qiaoqiao Sun, Beibei Zhou, Yiqun Peng, **gyun Li, Chunyan Li… in Metabolomics (2024)

Article

Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α

Tripartite motif 8 (TRIM8) is an E3 ligase that plays dual roles in various tumor types. The biological effects and underlying mechanism of TRIM8 in hepatocellular carcinoma (HCC) remain unknown. Hepatocyte nu...

Yu Peng, Hui Qian, Wen-** Xu, Meng-Chao **ao, Chen-Hong Ding… in Cell Death & Disease (2024)

Article

Prostaglandin I₂ signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice

Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis is a pathological hallmark of structural remodeling in AF. Prostaglandin I₂ (PGI₂) can prevent the process of fibrosis in various tissue...

Yue Zhang, Meng Yuan, Wenbin Cai, Weiyan Sun… in Cellular and Molecular Life Sciences (2024)

Article

Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth

The hypercoagulable state is a hallmark for patients with multiple myeloma (MM) and is associated with disease progression. Activated platelets secrete exosomes and promote solid tumor growth. However, the rol...

Meng Gao, Hang Dong, Siyi Jiang, Fang** Chen, Yunfeng Fu, Yanwei Luo in Oncogenesis (2024)

Article

Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition and...

Yun Yang, Qingya Liu, Meng Wang, Lang Li… in Signal Transduction and Targeted Therapy (2024)

Article

Pharmacological inhibition of RUNX1 reduces infarct size after acute myocardial infarction in rats and underlying mechanism revealed by proteomics implicates repressed cathepsin levels

Myocardial infarction (MI) results in prolonged ischemia and the subsequent cell death leads to heart failure which is linked to increased deaths or hospitalizations. New therapeutic targets are urgently neede...

Hengshu Chen, Si Wang, **aoling Zhang, **ng Hua… in Functional & Integrative Genomics (2024)

Article

DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer

Metabolic reprogramming has become increasingly important in tumor biology research. The glucose metabolic pathway is a major energy source and is often dysregulated in breast cancer. DAB2IP is widely reported...

Hongliang Dong, Weiyi Jia, Weijian Meng, Rui Zhang, Zhihong Qi, Zhuo Chen… in Oncogenesis (2024)

Article

Poly (ADP-ribose) polymerase 1 promotes HuR/ELAVL1 cytoplasmic localization and inflammatory gene expression by regulating p38 MAPK activity

Post-transcriptional regulation of cytokine/chemokine mRNA turnover is critical for immune processes and contributes to the mammalian cellular response to diverse inflammatory stimuli. The ubiquitous RNA-bindi...

**ngyue Fu, Jiaqi Zhang, Keke Sun, Meiqi Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Retraction Note: Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis

Jihua Han, Changming **e, Tiemin Pei, Jiabei Wang, Yaliang Lan… in Cell Death & Disease (2024)

Article

Dysregulated dendritic cells in sepsis: functional impairment and regulated cell death

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Studies have indicated that immune dysfunction plays a central role in the pathogenesis of sepsis. D...

Li-yu Zheng, Yu Duan, Peng-yi He, Meng-yao Wu… in Cellular & Molecular Biology Letters (2024)

Article

Protective Effect of CXCR7 Against Hypoxia/Reoxygenation Injury in Renal Tubular Epithelial Cells

Acute kidney injury (AKI) is a multifactorial syndrome with complex pathophysiology and prognosis. Ischaemia‒reperfusion injury (IRI) is a major cause of induced AKI. The aim of this study was to investigate t...

** Meng, Chunli Liu, **gchun Li, ** Fang… in Cell Biochemistry and Biophysics (2024)