937 Result(s)

Article

Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy

Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic disorders, including asthma, allergic rhinitis, atopic derm...

Ruiming Han, Dongdong Zhu, Jichao Sha, Boning Zhao, Peng **… in Cell & Bioscience (2024)

Article

Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation

**anwen Ye, Zixuan Huang, Yi Li, Mengjiao Wang, Wanyu Meng, Maojian Miao… in Cell Research (2024)

Article

Proteomic profiling of prostate cancer reveals molecular signatures under antiandrogen treatment

Tumorigenesis and progression of prostate cancer (PCa) are indispensably dependent on androgen receptor (AR). Antiandrogen treatment is the principal preference for patients with advanced PCa. However, the mol...

Yurun Huang, Guanglin Yang, **npeng Yao, Yue Fang, Qiliang Lin… in Clinical Proteomics (2024)

Article

VHL suppresses UBE3B-mediated breast tumor growth and metastasis

Protein homeostasis is predominantly governed through post-translational modification (PTM). UBE3B, identified as an oncoprotein, exhibits elevated protein levels in breast cancer. However, the impact of PTM o...

Shuo Wang, Huiyan Li, **ong Liu, Tingting Yin, Tingru Li… in Cell Death & Disease (2024)

Article

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity

Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to better understand the key molecules responsible for determining...

Peiran Feng, Liang Luo, Quanli Yang, Wanqing Meng, Zerong Guan… in Cell Death & Disease (2024)

Article

Lipidomic signatures in patients with early-onset and late-onset Preeclampsia

Preeclampsia is a pregnancy-specific clinical syndrome and can be subdivided into early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) according to the gestational age of delivery. Patients with ...

Yu Huang, Qiaoqiao Sun, Beibei Zhou, Yiqun Peng, **gyun Li, Chunyan Li… in Metabolomics (2024)

Article

Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α

Tripartite motif 8 (TRIM8) is an E3 ligase that plays dual roles in various tumor types. The biological effects and underlying mechanism of TRIM8 in hepatocellular carcinoma (HCC) remain unknown. Hepatocyte nu...

Yu Peng, Hui Qian, Wen-** Xu, Meng-Chao **ao, Chen-Hong Ding… in Cell Death & Disease (2024)

Article

Prostaglandin I₂ signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice

Atrial fibrillation (AF) is the most common arrhythmia, and atrial fibrosis is a pathological hallmark of structural remodeling in AF. Prostaglandin I₂ (PGI₂) can prevent the process of fibrosis in various tissue...

Yue Zhang, Meng Yuan, Wenbin Cai, Weiyan Sun… in Cellular and Molecular Life Sciences (2024)

Article

Pharmacological inhibition of RUNX1 reduces infarct size after acute myocardial infarction in rats and underlying mechanism revealed by proteomics implicates repressed cathepsin levels

Myocardial infarction (MI) results in prolonged ischemia and the subsequent cell death leads to heart failure which is linked to increased deaths or hospitalizations. New therapeutic targets are urgently neede...

Hengshu Chen, Si Wang, **aoling Zhang, **ng Hua… in Functional & Integrative Genomics (2024)

Article

Poly (ADP-ribose) polymerase 1 promotes HuR/ELAVL1 cytoplasmic localization and inflammatory gene expression by regulating p38 MAPK activity

Post-transcriptional regulation of cytokine/chemokine mRNA turnover is critical for immune processes and contributes to the mammalian cellular response to diverse inflammatory stimuli. The ubiquitous RNA-bindi...

**ngyue Fu, Jiaqi Zhang, Keke Sun, Meiqi Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Retraction Note: Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis

Jihua Han, Changming **e, Tiemin Pei, Jiabei Wang, Yaliang Lan… in Cell Death & Disease (2024)

Article

Dysregulated dendritic cells in sepsis: functional impairment and regulated cell death

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Studies have indicated that immune dysfunction plays a central role in the pathogenesis of sepsis. D...

Li-yu Zheng, Yu Duan, Peng-yi He, Meng-yao Wu… in Cellular & Molecular Biology Letters (2024)

Article

Protective Effect of CXCR7 Against Hypoxia/Reoxygenation Injury in Renal Tubular Epithelial Cells

Acute kidney injury (AKI) is a multifactorial syndrome with complex pathophysiology and prognosis. Ischaemia‒reperfusion injury (IRI) is a major cause of induced AKI. The aim of this study was to investigate t...

** Meng, Chunli Liu, **gchun Li, ** Fang… in Cell Biochemistry and Biophysics (2024)

Article

IFRD1 promotes tumor cells “low-cost” survival under glutamine starvation via inhibiting histone H1.0 nucleophagy

Glutamine addiction represents a metabolic vulnerability of cancer cells; however, effective therapeutic targeting of the pathways involved remains to be realized. Here, we disclose the critical role of interf...

Yabin Huang, Fanzheng Meng, Taofei Zeng, Rick Francis Thorne, Lifang He… in Cell Discovery (2024)

Article

IL-33/NF-κB/ST2L/Rab37 positive-feedback loop promotes M2 macrophage to limit chemotherapeutic efficacy in lung cancer

IL-33 is a danger signal that binds to its receptor ST2L to promote tumor progression. This study identifies the IL-33/ST2L positive-feedback loop and the trafficking of ST2L membrane presentation in macrophag...

You-En Yang, Meng-Hsuan Hu, Yen-Chen Zeng, Yau-Lin Tseng… in Cell Death & Disease (2024)

Article

Distinct epigenetic modulation of differentially expressed genes in the adult mouse brain following prenatal exposure to low-dose bisphenol A

Bisphenol A (BPA) is a common component in the manufacture of daily plastic consumer goods. Recent studies have suggested that prenatal exposure to BPA can increase the susceptibility of offspring to mental il...

Jie Weng, Yue-yan Zhu, Li-yong Liao, **n-tong Yang… in Cell Biology and Toxicology (2024)

Article

LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination

A long-standing hypothesis proposes that certain RNA(s) must exhibit structural roles in microtubule assembly. Here, we identify a long noncoding RNA (TubAR) that is highly expressed in cerebellum and forms RNA–p...

**aolin Liang, Meng Gong, Zhikai Wang, Jie Wang, Weiwei Guo, Aoling Cai… in Cell Discovery (2024)

Article

Metabolic self-feeding in HBV-associated hepatocarcinoma centered on feedback between circulation lipids and the cellular MAPK/mTOR axis

Hepatitis B Virus (HBV) is widely recognized as a “metabolic virus” that disrupts hepatic metabolic homeostasis, rendering it one of the foremost risk factors for hepatocellular carcinoma (HCC). Except for ant...

Ying Zhu, Yingke Zhao, Zhouyu Ning, Yong Deng, Bing Li… in Cell Communication and Signaling (2024)

Article

P62 promotes FSH-induced antral follicle formation by directing degradation of ubiquitinated WT1

In females, the pathophysiological mechanism of poor ovarian response (POR) is not fully understood. Considering the expression level of p62 was significantly reduced in the granulosa cells (GCs) of POR patien...

Ting Zhao, Meina He, Zijian Zhu, Tuo Zhang… in Cellular and Molecular Life Sciences (2024)

Article

The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis

Colorectal cancer (CRC) remains a significant global health issue with high incidence and mortality. Yin Yang 1 (YY1) is a powerful transcription factor that acts dual roles in gene activation and repression. ...

Zhi-Ying Shao, Wen-Dong Yang, Hui Qiu, Zhi-Hong He, Meng-Ru Lu… in Cell Death & Disease (2024)