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Article
Open AccessLimiting factors for charge generation in low-offset fullerene-based organic solar cells
Free charge generation after photoexcitation of donor or acceptor molecules in organic solar cells generally proceeds via (1) formation of charge transfer states and (2) their dissociation into charge separate...
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Article
Open AccessAssociation of HLA-DRB1 locus with treatment response to abatacept or TNF inhibitors in patients with seropositive rheumatoid arthritis
The strongest genetic risk factor for rheumatoid arthritis (RA) has been known as HLA-DRB1 based on amino acid positions 11, 71, and 74. This study analyzed the association between specific HLA-DRB1 locus and ...
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Article
Open AccessIncreased cardiovascular risk in Korean patients with systemic lupus erythematosus: a population-based cohort study
To determine the increased risk of major adverse cardiovascular events (MACE) in patients with systemic lupus erythematosus (SLE) compared to the general population in Korea. Using data from the National Healt...
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Article
Open AccessDeep learning visual field global index prediction with optical coherence tomography parameters in glaucoma patients
The aim of this study was to predict three visual filed (VF) global indexes, mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI), from optical coherence tomography (OCT) paramet...
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Article
Open AccessIncreased risk of herpes zoster with tofacitinib treatment in Korean patients with rheumatoid arthritis: a single-center prospective study
We aimed to determine the risk of herpes zoster (HZ) in Korean rheumatoid arthritis (RA) patients on tofacitinib compared with tumor necrosis factor inhibitor (TNFi) treatment. From the prospective cohorts of ...
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Article
Open AccessQuantitative analysis of exosomes in the aqueous humor of Korean patients with pseudoexfoliation glaucoma
We aimed to quantitatively analyze the exosome and its cargo in individual aqueous humor (AH) samples from pseudoexfoliation (PEX) glaucoma patients compared to controls using a novel detection platform. We in...
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Article
Open AccessA new non-human primate model of desiccating stress-induced dry eye disease
Dry eye disease (DED), a multifactorial ocular surface disease, is estimated to affect up to 34% of individuals over 50 years old. Although numerous animal models, including rodents and rabbits, have been deve...
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Article
Open AccessMicroRNA profiles in aqueous humor between pseudoexfoliation glaucoma and normal tension glaucoma patients in a Korean population
We aimed to obtain microRNA (miRNA) profiles of patients with pseudoexfoliation (PEX) glaucoma or normal-tension glaucoma (NTG) compared to normal controls using individual aqueous humor (AH) samples and inves...
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Article
Metastable hexagonal close-packed palladium hydride in liquid cell TEM
Metastable phases—kinetically favoured structures—are ubiquitous in nature1,2. Rather than forming thermodynamically stable ground-state structures, crystals grown from high-energy precursors often initially adop...
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Open AccessAuthor Correction: Aqueous humor analyses of diabetic macular edema patients with subretinal fluid
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Article
Open AccessSuppression of lipopolysaccharide-induced corneal opacity by hepatocyte growth factor
Keratitis induced by bacterial toxins, including lipopolysaccharide (LPS), is a major cause of corneal opacity and vision loss. Our previous study demonstrates hepatocyte growth factor (HGF) promotes epithelia...
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Article
Open AccessLong noncoding RNAs associated with nonalcoholic fatty liver disease in a high cholesterol diet adult zebrafish model
The mechanism of nonalcoholic fatty liver disease (NAFLD) has not been completely revealed. In this study, we investigated the association of liver histological changes and long noncoding RNAs (lncRNAs) in the...
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Article
Open AccessAqueous humor analyses of diabetic macular edema patients with subretinal fluid
We identified treatment-naïve diabetic macular edema (DME) patients with or without subretinal fluid (SRF). We compared their baseline characteristics: aqueous concentrations of interleukin (IL)-1β, IL-2, IL-6...
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Article
Open AccessProfiles of microRNA in aqueous humor of normal tension glaucoma patients using RNA sequencing
We aimed to identify and compare microRNAs (miRNAs) from individual aqueous humor samples between normal-tension glaucoma (NTG) patients and normal controls. Aqueous humor (80 to 120 µl) was collected before c...
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Article
Open AccessDeep learning classification of early normal-tension glaucoma and glaucoma suspects using Bruch’s membrane opening-minimum rim width and RNFL
We aimed to classify early normal-tension glaucoma (NTG) and glaucoma suspect (GS) using Bruch’s membrane opening-minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer (RNFL), and the color clas...
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Article
Open AccessAssociation between noninvasive assessment of liver fibrosis and coronary artery calcification progression in patients with nonalcoholic fatty liver disease
Advanced liver fibrosis and coronary artery calcification (CAC) progression has been reported to correlate with cardiovascular disease. This study investigated the association between noninvasive liver fibrosi...
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Article
Open AccessNanoscale light element identification using machine learning aided STEM-EDS
Light element identification is necessary in materials research to obtain detailed insight into various material properties. However, reported techniques, such as scanning transmission electron microscopy (STE...
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Article
Position-specific oxidation of miR-1 encodes cardiac hypertrophy
In pathophysiology, reactive oxygen species oxidize biomolecules that contribute to disease phenotypes1. One such modification, 8-oxoguanine2 (o8G), is abundant in RNA3 but its epitranscriptional role has not bee...
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Article
Open AccessThe Impact of NAFLD and Waist Circumference Changes on Diabetes Development in Prediabetes Subjects
The aim of this study was to investigate the association of nonalcoholic fatty liver disease (NAFLD) with diabetes and the impact of waist circumference (WC) changes in subjects with prediabetes. We enrolled 6...
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Article
Open AccessThe impact of non-alcoholic fatty liver disease and metabolic syndrome on the progression of coronary artery calcification
It is unclear whether non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular disease. We examined the independent impact of NAFLD on the progression of the coronary artery c...