28 Result(s)
within
**kyung Cho
Biomedicine
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Article
Open AccessExosome-mediated secretion of miR-127-3p regulated by RAB27A accelerates metastasis in renal cell carcinoma
The exosome-mediated extracellular secretion of miRNAs occurs in many cancers, and RAB27A is a potent regulator of exosome secretion. For metastatic renal cell carcinoma (RCC), this study examines the mechanis...
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Author Correction: Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance
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Open AccessImpact of high dose radiotherapy for breast tumor in locoregionally uncontrolled stage IV breast cancer: a need for a risk-stratified approach
Patients with locoregionally uncontrolled breast tumors are frequently referred for breast palliative radiotherapy (PRT) to mitigate symptoms. We analyzed the outcomes following breast PRT to optimize PRT acco...
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Open AccessAmivantamab plus lazertinib in osimertinib-relapsed EGFR-mutant advanced non-small cell lung cancer: a phase 1 trial
Patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) often develop resistance to current standard third-generation EGFR tyrosine kinase inhibitors (TKIs); no targeted t...
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Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance
Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others. Astrocytes are implicated in optimizing the balance between e...
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Open AccessDummy run quality assurance study in the Korean Radiation Oncology Group 19 − 09 multi-institutional prospective cohort study of breast cancer
The Korean Radiation Oncology Group (KROG) 19 − 09 prospective cohort study aims to determine the effect of regional nodal irradiation on regional recurrence rates in ypN0 breast cancer patients. Dosimetric va...
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FCH domain only 1 (FCHo1), a potential new biomarker for lung cancer
Lung carcinoma is the main reason for cancer-associated deaths in the world. In a previous study, FCH domain only 1 (FCHo1) which is managed by protein kinase B (AKT), was shown to be activated in lung cancer....
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Open AccessDiagnostic performance of automated, streamlined, daily updated exome analysis in patients with neurodevelopmental delay
The diagnostic yield of whole-exome sequencing (WES) varies from 30%–50% among patients with mild to severe neurodevelopmental delay (NDD)/intellectual disability (ID). Routine retrospective reanalysis of undi...
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Open AccessAn open-label expanded access program of afatinib in EGFR tyrosine kinase inhibitor-naïve patients with locally advanced or metastatic non-small cell lung cancer harboring EGFR mutations
Afatinib is approved globally for EGFR-TKI treatment-naïve patients with EGFR mutation-positive non-small cell lung cancer (NSCLC). In this Korean expanded access program, we evaluated its ‘real-world’ safety and...
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Open AccessOptimal radiotherapy for patients with internal mammary lymph node metastasis from breast cancer
This study aimed to determine the optimal radiotherapy (RT) regimen for patients with clinical metastasis to the internal mammary lymph node (cIMN+) from breast cancer.
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Open AccessTargeting metastatic breast cancer with peptide epitopes derived from autocatalytic loop of Prss14/ST14 membrane serine protease and with monoclonal antibodies
In order to develop a new immunotherapeutic agent targeting metastatic breast cancers, we chose to utilize autocatalytic feature of the membrane serine protease Prss14/ST14, a specific prognosis marker for ER ...
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Anti-erythema and anti-edema activities of lactic acid bacteria extracts in mice
We examined the anti-inflammatory activities of 10 lactic acid bacteria extracts, obtained by lysozyme treatment. Among ferments of the 10 species, Bifidobacterium lactis showed the highest anti-erythema (73.4%) ...
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Open AccessF-box only protein 9 is an E3 ubiquitin ligase of PPARγ
Peroxisome proliferator-activated receptor gamma (PPARγ) is a critical regulator of carbohydrate and lipid metabolism, adipocyte differentiation and inflammatory response. Post-translational modification of PP...
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Open AccessFacilitation of corticospinal excitability by virtual reality exercise following anodal transcranial direct current stimulation in healthy volunteers and subacute stroke subjects
There is growing evidence that the combination of non-invasive brain stimulation and motor skill training is an effective new treatment option in neurorehabilitation. We investigated the beneficial effects of ...
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Comparison on physical property, dissolution and disintegration of four launched orally disintegration film (ODF) products for erectile dysfunction
Commercially available orally disintegration films (ODF) for erectile dysfunction were Viagra L® 50 and 100 mg by Pfizer Pharmaceuticals Korea Ltd., and Mvix S® 50 and 100 mg by SK Chemicals Co. The comparative s...
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Article
Anti-inflammatory Effects of Botulinum Toxin Type A in a Complete Freund’s Adjuvant-Induced Arthritic Knee Joint of Hind Leg on Rat Model
The objective of the study is to verify histopathologically the anti-inflammatory effect of botulinum toxin type A (BoNT-A) in a Complete Freund’s Adjuvant (CFA)-induced arthritic knee joint of hind leg on rat...
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Clinical significance of Ki-67 and p53 expression in curatively resected non-small cell lung cancer
The aim of this study is to explore the association of Ki-67 and p53 expression with prognosis in non-small cell lung cancer (NSCLC) patients who underwent curative resection. We retrospectively identified 116...
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Open AccessRecent Updates on Acetaminophen Hepatotoxicity: The Role of Nrf2 in Hepatoprotection
Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and anti-pyretic properties. Inappropriate use of APAP causes major morbidity and mortality secondary to hepatic...
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Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults
Little is known if lifestyle-related risk factors modulate the adiponectin genetic effects on its outcome phenotypes. The aims of the study were to investigate whether the association between the adiponectin g...
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Combined effects of body mass index and cardio/respiratory fitness on serum vaspin concentrations in Korean young men
Little information is available regarding how body fatness and cardio/respiratory fitness (CRF) are associated with serum vaspin. The purpose of the study was to investigate the combined effect of body mass in...
