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Article
Upper Semicontinuity of Random Attractors for Random Differential Equations with Nonlinear Diffusion Terms I: Finite-Dimensional Case
The upper semicontinuity of random attractors for stochastic/random (partial) differential equations with nonlinear diffusion term is an unsolved problem. In this paper, we first show the existence of random a...
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Article
Molecular design and energetic properties of 4H, 8H difurazano [3,4-b; 3′, 4′-e] pyrazine derivatives
Forty-five “4H, 8H difurazano[3,4-b;3′,4′-e] pyrazine (DFP) based energetic derivatives” were designed, and their heat of formation, stability, detonation performance, and impact sensitivity properties were co...
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Article
Structure and properties of 4a,5,7a, 8-tetrahydro-4H-imidazolo [4,5-b] [1, 2, 5] oxadiazolo [3,4-e] pyrazine-6 (7H)-ketone based energetic derivatives
During the research process, it was found that compounds with the "565" ring structure exhibited excellent detonation performance, which led to further investigation. TIOP (4a,5,7a, 8-tetrahydro-4H-imidazolo [...
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Article
Open AccessIschemic cardio-cerebrovascular disease and all-cause mortality in Chinese elderly patients: a propensity-score matching study
Ischemic cardio-cerebrovascular disease is the leading cause of mortality worldwide. However, studies focusing on elderly and very elderly patients are scarce. Hence, our study aimed to characterize and invest...
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Article
Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase
To provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction (JP) and to explore its mechanism of anti-cancer cachexia.
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Article
Theoretical study on different substituent-modified derivatives of 6-dinitrophenyl-5,6,7,8-tetrahydro-4-imidazo [4,5-e]furazano[3,4-b] pyrazine
The compounds of the “565” parent ring structure have received much attention from researchers because of their excellent detonation performance. In the present study, 81 derivatives were designed by introduci...
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Article
Review on the progress and future prospects of geological disasters prediction in the era of artificial intelligence
Geological disasters such as landslide, debris flow and collapse are major natural disasters faced by both China and the world, which seriously threaten people’s lives, property security and the socio-economic...
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Article
Open AccessSlower-decaying tropical cyclones produce heavier precipitation over China
The post-landfall decay of tropical cyclones (TC) is often closely linked to the magnitude of damage to the environment, properties, and the loss of human lives. Despite growing interest in how climate change ...
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Article
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice
Atrial fibrillation (AF), the most common cardiac arrhythmia, is an important contributor to mortality and morbidity. Ubquitin-specific protease 7 (USP7), one of the most abundant ubiquitin-specific proteases ...
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Article
Left ventricular entropy is a novel predictor of major adverse cardiac events (MACE) in patients with coronary atherosclerosis: a multi-center study
To investigate the incremental prognostic value of left ventricular (LV) entropy in a large multi-center population with coronary atherosclerotic heart disease (CAD).
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Article
Open AccessDevelopment and validation of a nomogram for predicting sever cancer-related fatigue in patients with cervical cancer
Cancer-related fatigue (CRF) has been considered the biggest influencing factor for cancer patients after surgery. This study aimed to develop and validate a nomogram for severe cancer-related fatigue (CRF) pa...
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Article
Open AccessCellular senescence and metabolic reprogramming model based on bulk/single-cell RNA sequencing reveals PTGER4 as a therapeutic target for ccRCC
Clear cell renal cell carcinoma (ccRCC) is the prevailing histological subtype of renal cell carcinoma and has unique metabolic reprogramming during its occurrence and development. Cell senescence is one of th...
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Article
Periodic DFT study of structural transformations of cocrystal CL-20/MMI under high pressure
The crystal and molecular structure, electronic properties, optical parameters, and elastic properties of a 1:2 hexanitrohexaazaisowurtzitane (CL-20)/2-mercapto-1-methylimidazole (MMI) cocrystal under 0 ~ 100 ...
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Article
Swin-TransUper: Swin Transformer-based UperNet for medical image segmentation
Convolutional Neural Network-based UNet and its variants have shown remarkable performance in medical image segmentation. However, these methods can only capture local features without spatial correlations and...
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Article
Genotype–phenotype correlations of neurofibromatosis type 1: a cross-sectional study from a large Chinese cohort
Neurofibromatosis type 1 (NF1) is a highly heterogeneous autosomal genetic disorder characterized by a broad spectrum of clinical and molecular manifestations. The correlations between genotype and phenotype i...
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Article
HSK3486 Inhibits Colorectal Cancer Growth by Promoting Oxidative Stress and ATPase Inhibitory Factor 1 Activation
HSK3486 (ciprofol), a new candidate drug similar to propofol, exerts sedative and hypnotic effects through gamma-aminobutyric acid type A receptors; however, its potential role in colorectal cancer is currentl...
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Article
Non-stationary modeling of seasonal precipitation series in Turkey: estimating the plausible range of seasonal extremes
It is increasingly recognized that the assumption of stationarity is not always appropriate for estimating return periods from meteorological time series under the effects of climate change and climate variabi...
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Article
A New Bioresource for Extracting Carrageenan and Phycoerythrin: Solieria tenuis, a Causative Species of Potential Marine Bloom
Solieria tenuis has the tendency to become a potential bloom in some regions of the sea in China. It has massive biomass. Therefore, making the best use of the bioresource of S. tenuis has gained attention. This ...
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Article
A dynamic spatiotemporal model for fall warning and protection
Early detection of falls is important for reducing fall injuries. However, existing fall detection strategies mostly focus on reducing impact injuries rather than avoiding falls. This study proposed the concep...
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Article
Targeting initial tumour–osteoclast spatiotemporal interaction to prevent bone metastasis
Bone is the most common site of metastasis, and although low proliferation and immunoediting at the early stage make existing treatment modalities less effective, the microenvironment-inducing behaviour could ...
