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Open AccessSerum matrix metalloproteinase-7 for discriminating biliary atresia: a diagnostic accuracy and validation study
Prompt and precise differential diagnosis of biliary atresia (BA) among cholestatic patients is of great importance. Matrix metalloproteinase-7 (MMP-7) holds great promise as a diagnostic marker for BA. This s...
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Open AccessEntry of ZSWIM4 to the nucleus is crucial for its inhibition of KIT and BMAL1 in gastrointestinal stromal tumors
Zinc finger SWIM-type containing 4 (ZSWIM4) is a zinc finger protein with its function largely uncharacterized. In this study, we aimed to investigate the role of ZSWIM4 in gastrointestinal stromal tumors (GIS...
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Article
Open AccessEffectiveness of spatial measurement model based on SDM-STIRPAT in measuring carbon emissions from transportation facilities
To gain a deeper understanding of the carbon emission mechanism from transportation facilities, all system elements affecting carbon emissions from regional transportation facilities are identified and analyze...
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Article
Interactive effects of ocean acidification and nitrate on Ulva lactuca
The global ocean is undergoing gradual acidification and eutrophication which may have significant impacts on macroalgal communities. However, little is known regarding the interactive effects of ocean acidifi...
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Article
The SOX2/PDIA6 axis mediates aerobic glycolysis to promote stemness in non-small cell lung cancer cells
Non-small cell lung cancer (NSCLC) is an aggressive and rapidly expanding lung cancer. Abnormal upregulation or knockdown of PDIA6 expression can predict poor prognosis in various cancers. This study aimed to ...
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Article
Big Hankel operators on Hardy spaces of strongly pseudoconvex domains
In this article, we investigate the (big) Hankel operator Hf on the Hardy spaces of bounded strongly pseudoconvex domains Ω in ℂn. We observe that Hf is bounded on Hp (Ω) (1 < p < ∞) if f belongs to BMO and we ob...
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Open AccessDiabetic kidney disease screening status and related factors: a cross-sectional study of patients with type 2 diabetes in six provinces in China
To understand the awareness and practice of diabetic kidney disease (DKD) or nephropathy screening among community-based patients with type 2 diabetes in six provinces and cities in China, and to analyse the r...
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Article
Open AccessWiden the debate: What is the academic community’s perception on ChatGPT?
ChatGPT has surprised academia with its remarkable abilities but also raised substantial concerns regarding academic integrity and misconduct. Despite the debate, empirical research exploring the issue is limi...
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Article
Adhesion molecule–targeted magnetic particle imaging nanoprobe for visualization of inflammation in acute lung injury
Uncontrolled intra-alveolar inflammation is a central pathogenic feature, and its severity translates into a valid prognostic indicator of acute lung injury (ALI). Unfortunately, current clinical imaging appro...
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Open AccessCough flows as a criterion for decannulation of autonomously breathing patients with tracheostomy tubes
Adequate cough or exsufflation flow can indicate an option for safe tracheostomy decannulation to noninvasive management. Cough peak flow via the upper airways with the tube capped is an outcome predictor for ...
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Article
Involvement of Calpain in Neurovascular Unit Damage through Up-regulating PARP-NF-κB Signaling during Experimental Ischemic Stroke
Calpain and PARP-NF-κB signaling are reported to participate in the ischemic brain injury. In this study, it was investigated whether calpain was contributed to the neurovascular unit (NVU) damage through up-r...
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Article
Open AccessABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
ABCA7 loss-of-function variants are associated with increased risk of Alzheimer’s disease (AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we investigated the impacts of ABCA7 deficiency o...
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Association of energy delivery with short-term survival in mechanically ventilated critically ill adult patients: a secondary analysis of the NEED trial
The optimal energy delivery for mechanically ventilated patients is controversial, particularly during the first week of ICU admission. This study aimed to investigate the association between different caloric...
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Open AccessExpression and prognosis analysis of TBX2 subfamily in human lung carcinoma
Lung cancer has a high morbidity and mortality rate of all cancers worldwide. Therefore, there is an urgent need for reliable cancer markers for diagnosis and prognosis of patients with lung cancer.
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Article
Open AccessSerum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma
The response to programmed death-1 (PD-1) blockade varies in hepatocellular carcinoma (HCC). We utilize a panel of 16 serum factors to show that a circulating level of serum amyloid A (SAA) > 20.0 mg/L has the...
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Open AccessLong noncoding RNA XIST promotes cell proliferation and migration in diabetic foot ulcers through the miR-126-3p/EGFR axis
The prevalence of diabetic foot ulcers (DFUs) has caused serious harm to human health. To date, a highly effective treatment is lacking. Long noncoding RNA X-inactive specific transcript (lncRNA XIST) has been...
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Article
Effect of Electroacupuncture Stimulation on Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Spinal Cord Injury
The aim of this work was to investigate the effects of electroacupuncture (EA) stimulation on the proliferation and differentiation of endogenous neural stem cells (NSCs) in rats with spinal cord injury (SCI)....
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Article
Predicting miRNA–Disease Associations by Combining Graph and Hypergraph Convolutional Network
miRNAs are important regulators for many crucial biological processes. Many recent studies have shown that miRNAs are closely related to various human diseases and can be potential biomarkers or therapeutic ta...
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Article
Open AccessLarge-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae
Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) is a promising tool to study genomic rearrangements. However, the potential of SCRaMbLE to study genomic rearrangements...
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Open AccessRetraction Note: Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7
